Spontaneous Pallidonigral Spheroids and Iron Pigment Accumulation, Macaques

Gliatto, John M.; Bronson, Roderick T.

doi:10.1007/978-3-642-84924-4_38

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…4). Pathological changes in the areas of these iron deposits in the globus pallidus and substantia nigra were well documented in macaque brains (Bronson & Schoene 1980;Gliatto & Bronson 1993;Cork & Walker (1993). Aspects of these lesions in human and macaque brains were also compared (Schoene et al 1977).…”

Section: Pathology Of the Brain In Aged Macaque I) Multiple Cerebral mentioning

confidence: 96%

Age-related pathology and biosenescent markers in captive rhesus macaques

Uno

1997

AGE

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During the past 15 years, our aging colony of rhesus monkeys, consisting of animals from 20 to 37 years of age, had an annual average population of 88.2 live monkeys and, of this population, an annual average of 13.9 monkeys died spontaneously or were terminated due to severe illness. From 1980 to 1994, a total of 175 autopsies of rhesus macaques, from 20 to 37 years of age, were performed. By cumulative autopsy data, the incidence of age-related pathology in various organs was surveyed. Major geriatric diseases such as coronary sclerosis, emphysema, degenerative joint disorders, cancer, and cerebral amyloid plaque began to develop in 10 to 40% of macaques after 20 years and the incidence significantly increased after 26 years of age. Approximately 12% of aged macaques from 20 to 30 years of age died annually due to such geriatric diseases with severe complications. The average survival rate indicated that half the population at 20 years of age died by 25 years and 73% died by 30 years of age. Less than 10% of macaques survived over 30 years. Using these aged macaques as well as other juvenile to adult monkeys in our Center, clinical opththalmological and reproductive endocrinological studies, and magnetic resonance imaging (MRI) of the brain were conducted to define bioaging markers of captive rhesus monkeys. Cataracts began to develop in 20% of rhesus monkeys at 20 to 22 years of age and the rate significantly increased after 26 years of age. Menopause occurred at 26 to 27 years of age. Multiple cerebral infarctions and iron deposits in the globus pallidus and substantia nigra were detected by MRI in the aged brains. These geriatric disorders in captive aged macaques appear to be natural aging outcomes, since the simple lifestyle of these captive animals offers minimal exposure to environmental factors. Our data will offer useful paradigms for preventive or experimental studies on age-related diseases.

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Section: Pathology Of the Brain In Aged Macaque I) Multiple Cerebral mentioning

confidence: 96%

Age-related pathology and biosenescent markers in captive rhesus macaques

Uno

1997

AGE

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“…Several incidental lesions have been described in the brains of aging nonhuman primates including macaques, squirrel monkeys, and lemurs (28,41,42,79). These include lipofuscinosis, senile amyloid plaques, cerebrovascular amyloidosis, spheroids, and iron pigment.…”

Section: Nervous Systemmentioning

confidence: 96%

A Primer of Primate Pathology: Lesions and Nonlesions

Lowenstine

2003

Toxicol Pathol

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Nonhuman primates are important laboratory animals for biomedical, pharmacology, and toxicology research. To effectively use primates as models, their gross and histologic anatomy, physiology and natural history, as well as common health problems and the source from which the primate is obtained, must be known and understood by pathologists involved in study design and/or interpretation. The first very important lesson in the "primer" is: there is no such thing as a generic monkey. Brand names (ie, species and subspecies) are important. Several taxonomic groups of primates are used in research including: prosimians, such as galagos and lemurs; New World monkeys, particularily marmosets; Old World monkeys, especially macaques and baboons; and the chimpanzee, an African ape. Differences between taxa are exemplified by the glucocorticoid resistance of New World monkeys compared to Old World monkeys, which results in the requirement for Vitamin D3 and their high circulating levels of steroids such as cortisone and progesterone. Differences in ovarian histology between Old and New World monkeys probably relate to steroid receptor biology as well. There are also variations in disease manifestations, even among closely related primate species such as rhesus and cynomolgus macaques (cynos). For example type D retrovirus infection is accompanied by lymphomas in cynos, but not rhesus. The second important lesson in this "primer" is: "not test article related" does not always mean "normal." Lymphoid nodules in bone marrow or salivary gland, a common background finding in macaques, often signal the presence of type D retrovirus. Other histologic changes and normal anatomic variations may be confusing to individuals not routinely examining primate tissues. The objective of this paper is to familiarize pathologists with the use of primates in research as well as lesions and nonlesions (normal anatomy or physiology) of primates that may influence study design and confound interpretation.

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Nervous System Disorders of Nonhuman Primates and Research Models

Fahey

Westmoreland

2012

Nonhuman Primates in Biomedical Research

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Spontaneous Pallidonigral Spheroids and Iron Pigment Accumulation, Macaques

Cited by 4 publications

References 12 publications

Age-related pathology and biosenescent markers in captive rhesus macaques

Age-related pathology and biosenescent markers in captive rhesus macaques

A Primer of Primate Pathology: Lesions and Nonlesions

Nervous System Disorders of Nonhuman Primates and Research Models

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