Spontaneous ovarian hyperstimulation syndrome caused by hypothyroidism in an adult

Predictive factors of early moderate/severe ovarian hyperstimulation syndrome in non-polycystic ovarian syndrome patients: a statistical model

“…Hypothyroidism is another postulated risk factor for the development of spontaneous OHSS [20][21][22], but the exact mechanism by which ovarian hyperstimulation syndrome might occur in hypothyroid patients is not clear. We found that hypothyroid NPCOS women are fivefold more at risk for developing OHSS.…”

Spontaneous ovarian hyperstimulation syndrome and pituitary hyperplasia mimicking macroadenoma associated with primary hypothyroidism

“…In this case, it is called spontaneous OHSS, which has often been reported in association with pregnancy, FSH-secreting adenoma, or exceptionally TSH-secreting macroadenoma [7] . Only a few cases of hypothyroidism have been described in the literature [1][2][3][4][5]8] . The pathogenesis of OHSS remains unclear.…”

“…In adults, the diagnosis is more challenging except in pregnant women who are known to have higher risks for thyroid disorders and spontaneous ovarian hyperstimulation syndrome (OHSS). To the best of our knowledge, only five cases of ovarian hyperstimulation associated with a pituitary mass in non-pregnant adult women with primary hypothyroidism have been previously described in the literature, and our case is the first to be reported in North America [1][2][3][4][5] .…”

Does elevated human chorionic gonadotropin alone trigger spontaneous ovarian hyperstimulation syndrome?

“…Ovarian hyperstimulation syndrome has been categorized into three types according to the proposed mechanisms (3): mutation of the FSH receptor (FSHr) (1), hypothyroidism (10)(11)(12), and elevated levels of hCG (5,13,14).…”