Spontaneous osteosarcoma in craniomaxillofacial fibrous dysplasia: clinical and computed tomographic features in 8 cases

Sun, Taotao; Tao, Xiaofeng; Shi, Huimin

doi:10.1016/j.oooo.2014.03.006

Cited by 17 publications

(20 citation statements)

References 18 publications

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“…After applying the inclusion and exclusion criteria, 14 studies were included for review. The manual search added five more studies, resulting in 19 articles included in this systematic review reporting the malignant transformation of 27 patients with FOLs . Only cases that fulfilled all the inclusion criteria within case series studies were included in this review.…”

Section: Resultsmentioning

confidence: 99%

“…The average period from initial FOL diagnosis to malignant transformation was 18.2 years (analysis made from 25 cases in which the time was reported). This period ranged from 4 months to 50 years …”

Section: Resultsmentioning

confidence: 99%

“…Concerning the outcome, five studies did not report any follow‐up information and one study only reported that the patient did not respond to therapy, yet the time of follow‐up was not mentioned . Among the other reports (n = 21), eight patients remained alive during the follow‐up, while 13 died because of the tumor.…”

Section: Resultsmentioning

confidence: 99%

“…The age of the patients at the time of malignant transformation was quite variable (16‐60 years), as was the period between initial diagnosis and this event. The average time from initial FOL diagnosis to malignant transformation was 18.2 years, ranging from 4 months to 50 years . More than 10 cases took more than 20 years to undergo malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

“…These data reveal that patients with FD need regular follow‐ups for a long period, not only to monitor aesthetic issues or to identify reactivations, but also to possibly diagnose a malignant tumor at early stages. Symptoms such as abrupt swelling, numbness, or pain might raise the suspicion of a malignant transformation, and patients should immediately undergo a new biopsy. Malignant tumors derived from FD were diagnosed mainly as osteosarcomas; however, cases of chondrosarcoma, malignant fibrous histiocytoma, and fibrosarcoma were also observed.…”

Section: Discussionmentioning

confidence: 99%

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Malignant transformation of craniomaxillofacial fibro‐osseous lesions: A systematic review

Wagner

Carlos²,

Romañach

et al. 2019

J Oral Pathology Medicine

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The purpose of this study was to perform a systematic review of the literature concerning all documented cases of malignant transformation of craniomaxillofacial fibro‐osseous lesions (FOLs). Three electronic databases were searched. Data were evaluated descriptively. Kaplan‐Meier survival curves were constructed and compared using the log‐rank test. A critical appraisal of included articles was performed through the Joanna Briggs Institute tool. A total of 19 studies including 27 patients were selected for data extraction. Twenty‐six cases were initially diagnosed as fibrous dysplasia and one as ossifying fibroma. The mean age at the time of malignant transformation was 38.11 years, and the average time from initial diagnosis to malignant transformation was 18.2 years. The male:female ratio was 1:1.2, and the maxilla:mandible ratio was 1.5:1. The histological type of the malignant tumor was predominantly osteosarcoma. Follow‐up was available for 21 patients. The 3‐year overall survival rate was 51%. Mandible tumors and diagnoses other than osteosarcoma tended to have poor survival rates, but no significant difference was identified. We concluded that between all FOLs, only fibrous dysplasia seems to have a considerable increased risk of malignant transformation. Thus, a regular and long follow‐up period is advised.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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