Spontaneous modifications of contrast enhancement in childhood non-cerebellar pilocytic astrocytomas

Gaudino, Simona; Quaglio, F. R.; Schiarelli, Chiara; Martucci, Matia; Tartaglione, Tommaso; Gualano, Maria Rosaria; Lella, Giuseppe Maria Di; Colosimo, Cesare

doi:10.1007/s00234-012-1010-3

Cited by 34 publications

(18 citation statements)

References 29 publications

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“…Spontaneous fluctuations of CE of PA has been reported, and CE changes were imaged in 12/39 (30.8%) patients with PA. 6) This change in CE happened without change in tumor size or MR imaging signal intensity. It is already known that the degree of CE at the time of radiological diagnosis is unreliable in predicting clinical behavior of PA. 7) Therefore, in our opinion, RGNT consisting of astrocytic cells with pilocytic morphology may have potential of showing a similar phenomenon.…”

Section: Discussionmentioning

confidence: 91%

Rosette-forming Glioneuronal Tumor: Rare Case Presented with Spontaneous Disappearance of Contrast Enhancement

Haryu

Saito

Kanamori

et al. 2015

NMC Case Report Journal

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Section: Discussionmentioning

confidence: 91%

Rosette-forming Glioneuronal Tumor: Rare Case Presented with Spontaneous Disappearance of Contrast Enhancement

Haryu

Saito

Kanamori

et al. 2015

NMC Case Report Journal

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“…Tumor size was estimated from maximal bidimensional measurements (ie, the area) via the product of the longest diameter and its longest perpendicular diameter for solid components of each lesion; cysts were excluded with the same criteria described for the randomized non‐NF study . Because enhancement can vary with technique and timing, the fluid attenuated inversion recovery and T2‐weighted images were primarily used by the central reviewers to determine responses …”

Section: Methodsmentioning

confidence: 99%

“…12 Because enhancement can vary with technique and timing, the fluid attenuated inversion recovery and T2-weighted images were primarily used by the central reviewers to determine responses. 14…”

Section: Evaluation Of the Tumor Responsementioning

confidence: 99%

Nonrandomized comparison of neurofibromatosis type 1 and non–neurofibromatosis type 1 children who received carboplatin and vincristine for progressive low‐grade glioma: A report from the Children's Oncology Group

Ater

Xia

Mazewski

et al. 2016

Cancer

101

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Purpose To evaluate tumor response, event-free survival (EFS), overall survival (OS), and toxicity of chemotherapy, children with NF1 and progressive low-grade gliomas (LGG) were enrolled on COG A9952 protocol and treated with carboplatin and vincristine (CV). Patients and Methods Non-NF1 patients were randomized to CV versus thioguanine, procarbazine, CCNU, vincristine (TPCV) on COG A9952. NF1 patients were assigned CV only. NF1 and non-NF1 patients, who were treated with CV, were compared on baseline characteristics, toxicity, tumor response, EFS, and OS. Results A total of 127 eligible patients with NF1 were non-randomly assigned to CV: 42 (33%) NF1 patients had events and 6 (4.7%) died. The 5-year EFS for the CV-NF1 group was 69% ± 4% versus 39% ± 4% for the CV-non-NF1 group (P<0.001). In univariate analysis, NF1 children had significantly higher tumor response rate and superior EFS and OS compared to CV-treated children without NF1. NF1 and non-NF1 patients differed significantly in amount of residual tumor, extent of resection, tumor location, and pathology. After multivariate analysis, NF1 was independently associated with better EFS (p < 0.001), but not with OS. NF1 patients also had decreased risk of grade 3 or 4 toxicities compared to non-NF1 patients. Three second malignant neoplasms (SMNs) occurred in NF1 patients receiving CV (CV-NF1), at a median of 7.8 years (range 7.3 to 9.4 years) after enrollment, but none in the non-NF1 group. Conclusions Children with NF1 tolerated CV well and had tumor response rate and EFS that were superior to children without NF1.

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“…Therefore, as in our case, in which the informed consent to the biopsy was denied, a “watchful waiting” management could be supported by the radiologic features consisting with a low-grade glial lesion and the absence of neurological deficits [37]. The interpretation of contrast enhancement is still debated [38]: in non-cerebellar gliomas, fluctuation of contrast enhancement during follow-up seemed to have no correlation with disease progression in absence of tumor size changes.…”

Section: Discussionmentioning

confidence: 98%

Congenital cystic eye associated with a low-grade cerebellar lesion that spontaneously regressed

et al. 2014

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BackgroundCongenital cystic eye is an exceedingly rare ocular malformative disease, originated from the failure in the invagination of the optic vesicle during the fetal period and it can be associated with other ocular and non-ocular abnormalities. Diagnosis is based on clinical, radiological and histological features.Case presentationWe report a case of a congenital cystic eye associated with a cerebellar lesion accidentally detected at magnetic resonance imaging. Biopsy of the mass has not been performed due to parental rejection. Based on radiologic features and absence of clinical signs, a low-grade glioma diagnosis was hypothesized, but histological characterization was not obtained. Follow-up neuro-imaging 6 months after diagnosis showed that intracranial lesion spontaneously regressed without any treatment.ConclusionOur report stresses the importance of early MRI in children with ocular malformations, in order to detect associated intracranial defects, also of non-malformative origin. Additionally, we debate the clinic-radiological features of the intracranial lesions that could allow a wait-and-see policy. We also recommend a strict clinical and neuro-imaging follow-up for these lesions. Finally, biological mechanisms at the base of spontaneous regression of the brain lesions are discussed.

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Spontaneous modifications of contrast enhancement in childhood non-cerebellar pilocytic astrocytomas

Abstract: In our experience, n-C PA may show variable CE over time in the absence of tumor/residual tumor dimension change. We recommend that CE fluctuations alone cannot be considered an indicator of tumor progression/regression.

Cited by 34 publications

References 29 publications

Rosette-forming Glioneuronal Tumor: Rare Case Presented with Spontaneous Disappearance of Contrast Enhancement

Rosette-forming Glioneuronal Tumor: Rare Case Presented with Spontaneous Disappearance of Contrast Enhancement

Nonrandomized comparison of neurofibromatosis type 1 and non–neurofibromatosis type 1 children who received carboplatin and vincristine for progressive low‐grade glioma: A report from the Children's Oncology Group

Congenital cystic eye associated with a low-grade cerebellar lesion that spontaneously regressed

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