Spontaneous Malformations of the New Zealand White Rabbit: The Background to Safety Evaluation Tests

Palmer, Anthony K.

doi:10.1258/002367768781082780

Cited by 71 publications

(31 citation statements)

References 2 publications

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“…These observations are in agreement with results on fetal weight, because a reduction in fetal weight is related to incomplete ossification of the skeleton [37]. Variation in thoracic rib number also occurred at high frequency in the control treatment (i.e., a 13th thoracic rib, see Table 3), but this is not unusual since previous studies have shown a high rate of spontaneous variation in rabbits [38].…”

Section: Resultssupporting

confidence: 91%

Maternal Stress Affects Fetal Growth but Not Developmental Instability in Rabbits

et al. 2016

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Developmental instability (DI), often measured by fluctuating asymmetry (FA) or the frequency of phenodeviants (fPD), is thought to increase with stress. However, specifically for stressors of maternal origin, evidence of such negative associations with DI is scarce. Whereas effects of maternal stress on DI have predominately been examined retroactively in humans, very little is known from experiments with well-defined stress levels in animal model systems. The aim of this study was to examine the effects of maternal exposure to three doses (plus a control) of a toxic compound affecting maternal condition on DI of their offspring in rabbits. Presence of maternal stress induced by the treatment was confirmed by a decrease in food consumption and weight gain of gravid females in the medium and high dose. Major abnormalities and mortality were unaffected by dose, suggesting the lack of toxic effects of the compound on the offspring. In spite of string maternal stress, offspring FA did not increase with dose. The treatment did lead to elevated fPD, but most were transient, reflecting growth retardation. Furthermore, a consistent association between fPD and FA was absent. These findings indicate that DI is not increased by maternal stress in this animal model.

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Section: Resultssupporting

confidence: 91%

Maternal Stress Affects Fetal Growth but Not Developmental Instability in Rabbits

et al. 2016

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“…6) with hypoplasia of the vertebral arch; and bipartite sternebrae. These anomalies have been reported in other breeds [4,7,9]. The frequency of skeletal variations was 9.1%, and the types of variation were as follows dumbbell shaped centra, 13 ribs, 8 lumbar vertebrae, asymmetry of sternebrae, and accessory sternebra.…”

Section: Toxicology and Experimentalsupporting

confidence: 60%

“…Multiple anomalies with acrania or thoraco-, gastroschisis are rare in the Japanese White [4,9], but in the New Zealand White, craniofacial and ventral body wall anomalies occur in 0.24% and 0.20% of fetuses, respectively [7]. Therefore, the frequency of these anomalies is similar in the JW-NIBS of this colony and New Zealand White rabbits.…”

Section: Toxicology and Experimentalmentioning

confidence: 76%

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Spontaneous Malformations in JW-NIBS Rabbits

Matsubara¹,

Yamanaka²,

Suzuki³

1984

Experimental Animals

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“…In rabbits the rate of abnormalities is relatively high, namely near or above 1% of viable fetuses [1,11]. By external examination, 30 of our fetuses (Table 2) showed malformations (0.3700) and among them omphalocele was most common (4/8060=0.050).…”

Section: Discussionmentioning

confidence: 83%

Litter Parameters and Spontaneous Abnormalities in Himalayan Rabbits

Lehmann

Matsuo

Niggeschulze

et al. 1986

Experimental Animals

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A joint study was undertaken in three testing facilities to evaluate cumulative background data of Himalayan rabbits.All litters were derived from control does. The conception rate was high (84.0-95.1%) but the average numbers of corpora lutea (7.9-8.7), implantation sites (6.5-7.5) and viable fetuses (5.8-6.9) were somewhat lower than that of most other strains of rabbit.Altogether 90 malfomed fetuses (1.12 %) and 425 fetuses with variations (5.270) occurred among 8, 060 virable fetuses.

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Spontaneous Malformations of the New Zealand White Rabbit: The Background to Safety Evaluation Tests

Cited by 71 publications

References 2 publications

Maternal Stress Affects Fetal Growth but Not Developmental Instability in Rabbits

Maternal Stress Affects Fetal Growth but Not Developmental Instability in Rabbits

Spontaneous Malformations in JW-NIBS Rabbits

Litter Parameters and Spontaneous Abnormalities in Himalayan Rabbits

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