Spontaneous Low Frequency Oscillations of Cerebral Hemodynamics and Metabolism in Human Adults

Obrig, Hellmuth; Neufang, Markus; Wenzel, Rüdiger; Kohl, Matthias; Steinbrink, Jens; Einhäupl, Karl M.; Villringer, Arno

doi:10.1006/nimg.2000.0657

Cited by 571 publications

(609 citation statements)

References 61 publications

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“…As we observed SSHOs in all patients, SSHOs can be detected using NIRS (Obrig et al, 2000; Sakudo, 2016), also when a patient is sedated. A SSHO may be confused with Mayer waves that are known to be globally present in all vessels.…”

Section: Implications For Other Domainssupporting

confidence: 58%

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Detailed view on slow sinusoidal, hemodynamic oscillations on the human brain cortex by Fourier transforming oxy/deoxy hyperspectral images

Noordmans

Blooijs

Siero

et al. 2018

Human Brain Mapping

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Slow sinusoidal, hemodynamic oscillations (SSHOs) around 0.1 Hz are frequently seen in mammalian and human brains. In four patients undergoing epilepsy surgery, subtle but robust fluctuations in oxy‐ and deoxyhemoglobin were detected using hyperspectral imaging of the cortex. These SSHOs were stationary during the entire 4 to 10 min acquisition time. By Fourier filtering the oxy‐ and deoxyhemoglobin time signals with a small bandwidth, SSHOs became visible within localized regions of the brain, with distinctive frequencies and a continuous phase variation within that region. SSHOs of deoxyhemoglobin appeared to have an opposite phase and 11% smaller amplitude with respect to the oxyhemoglobin SSHOs. Although the origin of SSHOs remains unclear, we find indications that the observed SSHOs may embody a local propagating hemodynamic wave with velocities in line with capillary blood velocities, and conceivably related to vasomotion and maintenance of adequate tissue perfusion. Hyperspectral imaging of the human cortex during surgery allow in‐depth characterization of SSHOs, and may give further insight in the nature and potential (clinical) use of SSHOs.

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Section: Implications For Other Domainssupporting

confidence: 58%

“…This method can be used to directly observe SSHOs on the human cortex itself. Due to the invasive character of having to remove the skull and dura, direct SSHO observations have been only sporadically described (Mitra, Ogawa, Hu, & Uǧurbil, 1997; Obrig et al, 2000; Rayshubskiy et al, 2014). …”

Section: Introductionmentioning

confidence: 99%

Detailed view on slow sinusoidal, hemodynamic oscillations on the human brain cortex by Fourier transforming oxy/deoxy hyperspectral images

Noordmans

Blooijs

Siero

et al. 2018

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Efforts for characterizing the components in the spectra have concentrated on establishing a physiological correspondence with the peaks or the energy bands. Functional MRI and transcranial Doppler sonography studies have proposed several association mechanisms of vasomotor dynamics while emphasizing the fact that a strong signal, the brain hemodynamic response, exists and dominates the lower portion of the spectrum computed from temporal neuroimaging data (Obrig et al, 2000a;Franceschini et al, 2000;Prince et al, 2003;Toronov et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…breathing, heart beat etc. ), other bands are affected by psychological or pathological conditions (or vice versa) through which degradation of task performance can be monitored (Kim and Ugurbil, 2002;Franceschini et al, 2000;Obrig et al, 2000a;Toronov et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Spectral Analysis of Event-Related Hemodynamic Responses in Functional Near Infrared Spectroscopy

2005

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Abstract. The goal of this paper is to design experiments that confirm the evidence of cognitive responses in functional near infrared spectroscopy and to establish relevant spectral subbands. Hemodynamic responses of brain during single-event trials in an odd-ball experiment are measured by functional near infrared spectroscopy method. The frequency axis is partitioned into subbands by clustering the time-frequency power spectrum profiles of the brain responses. The predominant subbands are observed to confine the 0-30 mHz, 30-60 mHz, and 60-330 mHz ranges. We identify the group of subbands that shows strong evidence of protocol-induced periodicity as well as the bands where good correlation with an assumed hemodynamic response models is found.

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Bio‐Optical Signals

Akin

2006

Wiley Encyclopedia of Biomedical Engineering

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Neuroimaging techniques aim to provide information regarding the physiological changes that take place during activation of the brain in cognitive tasks. One such system, recently established, is the functional near‐infrared spectroscopy that uses light sources in the range of 650–950 nm to probe the underlying brain regions. The main absorbers of light within this range is the oxygenated hemoglobin (HbO 2 ) and deoxygenated hemoglobin (Hb). The signal obtained from the prefrontal cortex of humans during cognitive tasks show that the increase of ([HbO 2 ]) concentration surpasses that of ([Hb]), which means that regional cerebral blood flow to the activated region has increased to compensate for the demand in oxygen and glucose utilization. This article aims to present the underlying physical and physiological principles giving rise to biooptical signals of the brain.

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Spontaneous Low Frequency Oscillations of Cerebral Hemodynamics and Metabolism in Human Adults

Cited by 571 publications

References 61 publications

Detailed view on slow sinusoidal, hemodynamic oscillations on the human brain cortex by Fourier transforming oxy/deoxy hyperspectral images

Detailed view on slow sinusoidal, hemodynamic oscillations on the human brain cortex by Fourier transforming oxy/deoxy hyperspectral images

Spectral Analysis of Event-Related Hemodynamic Responses in Functional Near Infrared Spectroscopy

Bio‐Optical Signals

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