Spontaneous Interstitial Myocarditis in Rabbits

Cp, Miller

doi:10.1084/jem.40.4.543

Cited by 44 publications

(10 citation statements)

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“…It should be noted that small foci of lymphocytes and monocytes, without associated muscle necrosis, as have been described by other investigators (27,28), were seen in most of the hearts from all the animals studied. The studies herein reported, like a number published previously from these and other laboratories (13)(14)(15), were designed to assay the effects of group A streptococcal infections on the hearts of rabbits.…”

Section: Control Studiessupporting

confidence: 80%

The Incidence and Pathogenesis of Myocarditis in Rabbits After Group a Streptococcal Pharyngeal Infections

Glaser

Thomas

Morse

et al. 1956

The Journal of Experimental Medicine

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Rabbits subjected to single pharyngeal infections with group A streptococci developed cardiac lesions characterized by myofiber necrosis and a non-granulocytic cellular reaction with histiocytes, lymphocytes, and Anitschkow myocytes. The histopathologic changes were demonstrable in some animals within 24 hours of inoculation, apparently were maximal 72 hours after induction of infection (at which time they were seen in the hearts of all nine rabbits studied), and thereafter healed in the course of the following 2 weeks. The extent of involvement was variable, and with healing the necrotic areas were replaced by fibrous tissue. When intradermal infections with the same organisms were produced in rabbits, cardiac lesions, indistinguishable from those observed in the pharyngeally infected group, appeared in a much smaller number of animals. The hearts of five of six rabbits sacrificed a month or more following the last of a series of streptococcal pharyngeal infections exhibited lesions characterized chiefly by fibrosis, although mononuclear cellular infiltrations were also noted. In these repetitively infected animals the presence of occasional multinucleated giant cells and a few small foci of calcification were features not encountered in the single infection group. In a second series of rabbits sacrificed 3 days after the last of three pharyngeal infections with different strains of streptococci, acute as well as more chronic changes were observed. In none of the lesions in rabbits subjected to single or multiple streptococcal infections were bacteria demonstrable, either in histologic sections or in cultures of myocardial tissue. A large number of control animals was studied concomitantly, and in only one instance was a lesion, considered comparable to those described in the streptococcal series, encountered. The implications of these findings, particularly in terms of the non-suppurative sequelae of streptococcal infections in man, are discussed.

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Section: Control Studiessupporting

confidence: 80%

The Incidence and Pathogenesis of Myocarditis in Rabbits After Group a Streptococcal Pharyngeal Infections

Glaser

Thomas

Morse

et al. 1956

The Journal of Experimental Medicine

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“…The interstitial myocarditis found in some of the rabbits during our experiments was unrelated to the injections and probably represented the spontaneous interstitial myocarditis sometimes encountered (11).…”

Section: Discussionsupporting

confidence: 52%

The Effect of Cortisone and 6-Mercaptopurine on Lesions Induced by Intramyocardial Injection of Streptococci

Laufer¹,

Ginsburg²,

Gery³

et al. 1963

Pathobiology

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“…Cellular infiltrates were occasionally seen in the rabbits, but they were limited in extent and could not he ascribed to the hypothermia, because similar changes were also found in the control animals. Cellular infiltrates in the heart muscles from apparently healthy rabbits have also been demonstrated by Miller ( 9 ) and Mc Keown ( l o ) , for example.…”

Section: It E S I' I T S a N D D I S C I' S S I 0 H'supporting

confidence: 58%

The Influence of Hypothermia on the Microscopical Picture of Different Organs in Rabbits

Hall

Björkman

Johansson

et al. 1960

Acta Pathologica Microbiologica Scandinavica

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Hypothermia was used some 20 years ago in the treatment of malignant tumours. During the last decade it has also been found useful in operations on the heart and on the brain. Methods now available for lowering the body temperature are regarded as safe. Nevertheless, some questions call for further investigation, such as: Does hypothermia produce morphological tissue changes?Microscopical changes after hypothermia have been observed in organs from various animals, but opinions differ in respect to both the extent and severity of the changes, and some authors even deny the occurrance of such changes.Artificial hypothermia, i.e. relatively rapid lowering of the general body temperature of anaesthetised human beings, found increasingly wide use after the fundamental investigations by Bigelow ( 1 ) . The microscopical changes described in these cases of hypothermia vary widely. Some authors, for example, found a n extracellular accumulation of fluid in different organs and degenerative changes and accumulation of inflammatory cells. Some investigators such as Sarajas ( 1 3 ) and Knocker ( 7 ) claim that these changes, a t least in dogs, are severe even if the organism is not cooled for any length of time, and even if the reduction in temperature is only small. On the other hand, other authors have not found any changes a t all or a t most slight changes (3, 6 ) . M A T E R I A L A N D M E T H O DNineteen full-grown rahhits were used. The animals anaesthetised with allylisohutylmalonylthiocarhamidesodium (Baytinal, Bayer) and afterwards cooled in a refrigerator ( 2 ) to $28" C. The temperature was maintained as steady as possihle at this level. Six rabbits were cooled for 48 hours, 2 for 34 and 2 for 38 and the remainder for 2-3 hours. Artificial respiration was not induced. The animals were killed immediately after the experiment. After careful gross inspection various organs (heart, liver, spleen, lungs and kidneys) were removed and fixed in 1 0 per cent formalin. 151

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Spontaneous Interstitial Myocarditis in Rabbits

Cited by 44 publications

References 1 publication

The Incidence and Pathogenesis of Myocarditis in Rabbits After Group a Streptococcal Pharyngeal Infections

The Incidence and Pathogenesis of Myocarditis in Rabbits After Group a Streptococcal Pharyngeal Infections

The Effect of Cortisone and 6-Mercaptopurine on Lesions Induced by Intramyocardial Injection of Streptococci

The Influence of Hypothermia on the Microscopical Picture of Different Organs in Rabbits

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