Spontaneous infarction of parathyroid adenoma: Case report and literature review

Mir, Rabia; Gerold, Thomas; Khan, Saad; Weitz, Jean

doi:10.1002/hed.2880150616

Cited by 18 publications

(12 citation statements)

References 4 publications

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“…Her anemia due to iron deficiency has also completely improved after oral ferrotherapy for 6 months. The spontaneous infarction of parathyroid adenoma rarely causes the biochemical remission, resulting in normocalcemia [3][4][5][6], which is also called as autoparathyroidectomy [6]. The hypocalcemia in the present case might be associated with the hungry bone state after the parathyroid infarction.…”

Section: Primary Hyperparathyroidismmentioning

confidence: 85%

Hypocalcemia due to Spontaneous Infarction of Parathyroid Adenoma and Osteomalacia in a Patient with Primary Hyperparathyroidism.

et al. 1998

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Abstract. A 49 year-old Japanese woman had subjected enlargement of a cervical tumor, and also suffered two bone fractures in 2 years. The cervical tumor had enlarged further in the month prior to admission, becoming warm and tender. Endocrinological examination revealed that the serum intact PTH concentration was remarkably high at 400 pg/mL despite the low serum calcium concentration, and that the serum vitamin Ds concentration was decreased. Bone roentgenograms revealed severe osteolytic changes compatible with osteitis fibrosa cystica and a pathologic fracture of the humerus. Under a diagnosis of primary hyperparathyroidism, parathyroidectomy was performed, followed by fixation surgery for the pathologic fracture. Histologically, the cervical tumor was a parathyroid chiefcell adenoma with massive necrosis, and the bone pathology by iliac bone biopsy revealed the existence of osteomalacia. She was treated with calcium, vitamins D and K2 and calcitonin after the surgery. This case is a rare condition manifesting hypocalcemia with catastrophic osteoporosis under the coexistence of spontaneous infarction of parathyroid adenoma with osteomalacia, suggesting that the clinical features of hyperparathyroidism are modified by both the autoparathyroidiectomy and the existence of osteomalacia due to vitamin D deficiency.

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Section: Primary Hyperparathyroidismmentioning

confidence: 85%

Hypocalcemia due to Spontaneous Infarction of Parathyroid Adenoma and Osteomalacia in a Patient with Primary Hyperparathyroidism.

et al. 1998

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“…Although this is a rare event, it is well documented and is most likely due to partial or total devascularization of the abnormal gland during cervical exploration. 23 …”

Section: Follow-upmentioning

confidence: 99%

Sporadic Primary Hyperparathyroidism in Young Patients

Harman

Heerden²,

Farley³

et al. 1999

Arch Surg

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“…The development of tetany and hypocalcemia after spontaneous remission has been reported rarely in the literature, but was observed in the present case [17]. It is known and hypothesized to consist of three phases [16,17].…”

mentioning

confidence: 37%

“…It is known and hypothesized to consist of three phases [16,17]. At first, massive release of PTH from a necrosed gland exacerbates the hyperclacemia, which is reflected by the worsening period of 1-2 weeks.…”

mentioning

confidence: 99%

A Case of Parathyroid Apoplexy of Primary Hyperparathyroidism Presenting as Auditory Hallucinations Accompanied with Hypocalcemia

2012

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The natural history of primary hyperparathyroidism, due to parathyroid adenoma, is unknown. Furthermore, spontaneous resolution of parathyroid necrosis or hemorrhage is rare and usually asymptomatic. Here, we report a case of parathyroid apoplexy of primary hyperparathyroidism, presenting as auditory hallucinations, accompanied with hypocalcemia. A 39-year-old man who was incidentally diagnosed with primary hyperparathyroidism, and waiting surgery for parathyroidectomy presented to psychiatric service with auditory hallucinations. He developed tetany, while taking psychiatric drugs. On a follow-up investigation, his serum calcium level fell from 11.8 to 5.8 mg/dL. His intact parathyroid hormone level also decreased from 1,017 pg/mL to 71.1 pg/mL. The parathyroid apoplexy was confirmed after a surgical removal of the infarcted adenoma. The auditory hallucinations disappeared, and serum calcium level was returned to within the normal range. (Endocrinol Metab 27:163-168, 2012)

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Spontaneous infarction of parathyroid adenoma: Case report and literature review

Abstract: A patient with asymptomatic primary hyperparathyroidism who spontaneously became normocalcemia is reported. The only significant finding was that of pain and tenderness in the enlarged parathyroid gland 2 weeks prior to surgery. This was due to a recent infarction of a parathyroid adenoma.

Cited by 18 publications

References 4 publications

Hypocalcemia due to Spontaneous Infarction of Parathyroid Adenoma and Osteomalacia in a Patient with Primary Hyperparathyroidism.

Hypocalcemia due to Spontaneous Infarction of Parathyroid Adenoma and Osteomalacia in a Patient with Primary Hyperparathyroidism.

Sporadic Primary Hyperparathyroidism in Young Patients

A Case of Parathyroid Apoplexy of Primary Hyperparathyroidism Presenting as Auditory Hallucinations Accompanied with Hypocalcemia

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