Spontaneous Hyphema Associated with Ingestion of<i>Ginkgo biloba</i>Extract

Rosenblatt, Marc; Mindel, Joel S.

doi:10.1056/nejm199704103361518

Cited by 323 publications

(136 citation statements)

References 3 publications

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“…The retrospective nature of the study also did not allow us to take into account any patients that may have been on Ginkgo biloba which has been incriminated as a cause of spontaneous hyphaema. 11 However, we believe the number of such patients, if any, would be too low to have a significant effect on the results.…”

Section: Discussionmentioning

confidence: 86%

The effect of aspirin and warfarin therapy in trabeculectomy

Cobb

Chakrabarti

Chadha

et al. 2006

Eye

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Aim The management of patients on antiplatelet and anticoagulation therapy (APACT) in glaucoma surgery currently has no specific recommendations. We aimed to establish the risk of haemorrhagic complications and surgical outcome in patients on APACT in glaucoma surgery. Methods We retrospectively examined 367 consecutive trabeculectomies performed between 1994 and 1998. Preoperatively 60 (16.4%) patients were on APACT (55 on aspirin and five on warfarin). The incidence of hyphaema and haemorrhagic complications between patients with and without APACT was documented. Surgical success was defined in two categories as an intraocular pressure (IOP) o21 mmHg and an IOP o16 mmHg 2 years following trabeculectomy with and without antiglaucoma medication. Results None of the patients on aspirin suffered significant intra or postoperative haemorrhage. Aspirin was associated with a significantly higher risk of hyphaema (P ¼ 0.0015) but this was not found to significantly affect IOP control at 2 years. Patients on warfarin suffered haemorrhagic complications and trabeculectomy failure. Conclusions Aspirin appears to be safe to continue with during trabeculectomy. Patients on aspirin have an increased risk of hyphaema following trabeculectomy. This however does not appear to affect surgical outcome. Warfarinised patients are at risk of serious bleeding complications. They require careful monitoring pre-and postoperatively and are at risk of trabeculectomy failure.

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Section: Discussionmentioning

confidence: 86%

The effect of aspirin and warfarin therapy in trabeculectomy

Cobb

Chakrabarti

Chadha

et al. 2006

Eye

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“…Its antiplatelet action has already been reported [1][2][3][4][5] , although there are controversies on this matter 22 . The anticoagulant effects of Ginkgo biloba have been reported mainly when this substance is used in combination with allopathic drugs, such as warfarin 5 , heparin 18 , aspirin 1,11,19,23 , and ibuprofen 24 . Therefore, dentists must be attentive to patients taking Ginkgo biloba, particularly when this substance is associated with other drugs of high hemorrhagic potential, before performing surgical procedures.…”

Section: Ginkgo Biloba (Gingko Biloba)mentioning

confidence: 99%

Anticoagulant effects of phytotherapeutic drugs and their importance in surgical dental procedures

Machado¹,

Cosme‐Silva

Cuba

et al. 2017

RGO, Rev. Gaúch. Odontol.

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Indexing terms: Blood coagulation factors. Phytotherapeutic drugs. Surgical dental procedures RESUMOFitoterápicos são produtos derivados de plantas com propriedades medicinais. Eles são utilizados para o tratamento ou a prevenção de diversas doenças. No entanto, os pacientes que fazem uso destas substâncias, na sua grande maioria, desconhecem seus efeitos negativos. Portanto, o objetivo deste estudo foi realizar uma breve revisão de literatura sobre os efeitos anticoagulantes de fitoterápicos e sua importância diante da realização de procedimentos odontológicos cirúrgicos. Medidas de prevenção, esclarecimento e acompanhamento de pacientes que se utilizam destes medicamentos são recomendados antes da realização destes procedimentos a fim de prevenir complicações como processos hemorrágicos.Termos de indexação: Fatores de coagulação sanguínea. Fitoterápicos. Procedimentos odontológicos cirúrgicos.

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“…85,86 Therefore, there is concern regarding increased risk of bleeding with ginkgo when coadministered with anticoagulants (Table 2) or antiplatelet drugs such as ticlopidine. 87 Bleeding events attributed to ginkgo use in warfarin-associated intracerebral hemorrhage, 88 ibuprofen-associated intracerebral mass bleeding, 89 aspirin-associated spontaneous hyphema, 90 postoperative bleeding 91 and subphrenic hematoma requiring laparoscopic evacuation 92 have been reported.…”

Section: Ginkgomentioning

confidence: 99%