Spontaneous Hemorrhage from Central Nervous System Hemangioblastomas

Ene, Chibawanye I.; Morton, Ryan P.; Ferreira, Manuel; Sekhar, Laligam N.; Kim, Louis J.

doi:10.1016/j.wneu.2015.02.009

Cited by 12 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Peritumoral cysts frequently underlie the clinical findings associated with hemangioblastomas, with at least 72% of symptomatic tumors but only 13% of asymptomatic tumors containing cysts [43]. In rare cases, hemangioblastomas may present with intraparenchymal, subarachnoid, or ventricular hemorrhage [44][45][46].…”

Section: Clinical Featuresmentioning

confidence: 99%

Neuropathologic features of central nervous system hemangioblastoma

Yoda¹,

Cimino

2022

J Pathol Transl Med

View full text Add to dashboard Cite

Hemangioblastoma is a benign, highly vascularized neoplasm of the central nervous system (CNS). This tumor is associated with loss of function of the VHL gene and demonstrates frequent occurrence in von Hippel-Lindau (VHL) disease. While this entity is designated CNS World Health Organization grade 1, due to its predilection for the cerebellum, brainstem, and spinal cord, it is still an important cause of morbidity and mortality in affected patients. Recognition and accurate diagnosis of hemangioblastoma is essential for the practice of surgical neuropathology. Other CNS neoplasms, including several tumors associated with VHL disease, may present as histologic mimics, making diagnosis challenging. We outline key clinical and radiologic features, pathophysiology, treatment modalities, and prognostic information for hemangioblastoma, and provide a thorough review of the gross, microscopic, immunophenotypic, and molecular features used to guide diagnosis.

show abstract

Section: Clinical Featuresmentioning

confidence: 99%

Neuropathologic features of central nervous system hemangioblastoma

Yoda¹,

Cimino

2022

J Pathol Transl Med

View full text Add to dashboard Cite

show abstract

“…Our patient of case 1 experienced sudden worsening of the brachial pain some days before the observation; at the operation, intralesional and extralesional bleeding was evidenced. Symptomatic bleeding is found from 2.9%[ 17 ] to 5.5%[ 18 ] of central nervous system hemangioblastomas, with a probability of 0.0024 per person per year. [ 17 ]…”

Section: Discussionmentioning

confidence: 99%

Spinal cervical extradural hemangioblastoma

Mariniello¹,

Corvino²,

Corazzelli³

et al. 2022

J Craniovert Jun Spine

View full text Add to dashboard Cite

Spinal cervical extradural and intra-extradural hemangioblastomas are exceptional, with only nine reported cases. This study reviews the diagnostic and surgical problems of this rare entity. Two female patients, aged 80 years and 25 years, respectively, one with Von Hippel–Lindau disease (VHLD), experienced brachial pain and weakness. On magnetic resonance imaging, a dumbbell intra-extraspinal hemangioblastoma was evidenced. The surgical resection through posterior laminectomy resulted in clinical remission of brachial pain and weakness. The magnetic resonance aspect of a dumbbell lesion suggests a neurogenic tumor; the correct preoperative diagnosis is possible in individuals with VHLD. The surgical problems include high tumor vascularity, vertebral artery control, and nerve root preservation. However, the surgical excision results in clinical remission.

show abstract

“…Some more recent series have reported some cases of acute hemorrhage with tumors noted to be smaller than 1.5 cm. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

Recurrent hemorrhage in hemangioblastoma involving the posterior fossa: Case report

Marvin¹,

Akhter²,

Coppens³

2017

Surg Neurol Int

View full text Add to dashboard Cite

Background:Hemangioblastomas (HGBs) are the most common primary intra-axial posterior fossa tumor in adults. Although spontaneous hemorrhage of these tumors is exceedingly rare, despite their vascular nature, we describe a case of recurrent hemorrhage with associated tonsillar herniation, and demonstrate that a surgical approach can provide a suitable outcome.Case Description:A 54-year-old female with von Hippel-Lindau (VHL) syndrome presented with acute loss of consciousness and Glasgow Coma Scale (GCS) was 4. Computed tomographic (CT) images demonstrated large volume subarachnoid hemorrhage of the posterior fossa with intraventricular extension and intraparenchymal hemorrhage involving the right cerebellar tonsil. Magnetic resonance imaging (MRI) displayed three lesions in the posterior fossa, two near the hemorrhage site. Patient underwent suboccipital craniectomy with a decent recovery followed by radiosurgery as she refused resection. A second hemorrhage occurred ultimately prompting surgical resection of the three posterior fossa lesions, with a reasonable postoperative course.Conclusion:Hemorrhage of HGBs of the posterior fossa can present in conjunction of tonsillar herniation. Re-hemorrhage appears to be likely if prior acute hemorrhage has occurred. A stepwise approach of surgical decompression and resection may provide the best outcome.

show abstract

Spontaneous Hemorrhage from Central Nervous System Hemangioblastomas

Cited by 12 publications

References 28 publications

Neuropathologic features of central nervous system hemangioblastoma

Neuropathologic features of central nervous system hemangioblastoma

Spinal cervical extradural hemangioblastoma

Recurrent hemorrhage in hemangioblastoma involving the posterior fossa: Case report

Contact Info

Product

Resources

About