Spontaneous glomerular mesangial lesions in common marmoset monkeys (<i>Callithrix jacchus</i>): a benign non‐progressive glomerulopathy

Collins, Michael G.; Rogers, Natasha M.; Jesudason, Shilpanjali; Kireta, Svjetlana; Brealey, John; Coates, P. Toby

doi:10.1111/jmp.12134

Cited by 18 publications

(6 citation statements)

References 41 publications

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“…Further, renal lesions were the most common lesion and of increased severity in the aged cohort. Histopathologic features were consistent with previously described renal pathologies in the common marmoset (Collins et al, 2014;Isobe et al, 2012;Tardif et al, 2011;Yamada, Sato, Kanno, Wako, & Tsuchitani, 2013) While we found no significant differences between young and old marmosets in the percent of time they were active versus at rest during daily behavioral observations, we did find that the way they moved within the cage differed. Older marmosets were significantly less likely to transition between quadrants within the cage than were young animals, suggesting that while they are moving they are not covering the same distances within the cage.…”

Section: Discussionsupporting

confidence: 91%

Cross‐sectional comparison of health‐span phenotypes in young versus geriatric marmosets

Ross

Adams

González

et al. 2019

American J Primatol

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The development of the marmoset as a translational model for healthspan and lifespan studies relies on the characterization of health parameters in young and geriatric marmosets. This crosssectional study examined health phenotypes in marmosets for five domains of interest for human health and aging: mobility, cognition, metabolism, homeostasis, and immune function. Geriatric marmosets were found to have significant executive function impairment when compared to young animals. While geriatric animals did not show gross abnormalities in mobility and measures of locomotion, their types of movement were altered from young animals. Geriatric marmosets had alterations in cardiac function, with significantly increased mean arterial pressures; metabolism, with significantly lower VO 2 ; and suppressed immune function. Further, this study sought to characterize and describe histopathology for both young and geriatric healthy marmosets. Overall this study provides a characterization of health parameters for young and geriatric marmosets which will greatly enhance future aging and interventional testing in marmosets.

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Section: Discussionsupporting

confidence: 91%

Cross‐sectional comparison of health‐span phenotypes in young versus geriatric marmosets

Ross

Adams

González

et al. 2019

American J Primatol

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“…Participants who were able to maintain optimal ART adherence were often able to do so because their treatment routines fit naturally within their daily routines [7], and accommodated, or at least did not increase, their degree of marginalization (e.g., offering delivery when a client was unable to pick up their medications). This is aligned with previous research demonstrating that health service delivery models must be flexible enough to accommodate the changing needs of PLHIV who use drugs (e.g., mobility restrictions) to support optimal health outcomes [20,[42][43][44], and in the context of our study, optimal ART adherence. However, while previous research [12,20,45,46], has documented similar causes of sub-optimal adherence (e.g., forgetting medication, prioritizing drug use) as our study, the discourse has often lacked an analysis of how the broader structural vulnerability of PLHIV who use drugs frames these treatment experiences.…”

Section: Discussionsupporting

confidence: 90%

A qualitative investigation of HIV treatment dispensing models and impacts on adherence among people living with HIV who use drugs

et al. 2021

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Antiretroviral therapy (ART) dispensing is strongly associated with treatment adherence. Among illicit drug-using populations, whom experience greater structural barriers to adherence, directly administered antiretroviral therapy (DAAT) is often regarded as a stronger predictor of optimal adherence over self-administered medications. In Vancouver, Canada, people living with HIV (PLHIV) who use drugs and live in low-income housing are a critical population for treatment support. This group is typically able to access two key DAAT models, daily delivery and daily pickup, in addition to ART self-administration. This ethno-epidemiological qualitative study explores how key dispensing models impact ART adherence among PLHIV who use drugs living in low-income housing, and how this is framed by structural vulnerability. Semi-structured interviews lasting 30–45 minutes were conducted between February and May 2018 with 31 PLHIV who use drugs recruited from an ongoing prospective cohort of PLHIV who use drugs. Interviews were audio-recorded, transcribed verbatim, and analyzed using QSR International’s NVivo 12 software. Interviews focused on housing, drug use, and HIV management. Models that constrained agency were found to have negative impacts on adherence and quality of life. Treatment interruptions were framed by structural vulnerabilities (e.g., housing vulnerability) that impacted ability to maintain adherence under certain dispensing models, and led participants to consider other models. Participants using DAAT models which accounted for their structural vulnerabilities (e.g., mobility issues, housing instability), credited these models for their treatment adherence, but also acknowledged factors that constrained agency, and the negative impacts this could have on both adherence, and quality of life. Being able to integrate ART into an established routine is key to supporting ART adherence. ART models that account for the structural vulnerability of PLHIV who use drugs and live in low-income housing are necessary and housing-based supports could be critical, but the impacts of such models on agency must be considered to ensure optimal adherence.

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“…Unfortunately, no urine reference values for glucose or pH values are stated for common marmosets. Following previously published urine protein values, patient W12 would be in the upper range and patient 1712.1 within the borderline .…”

Section: Discussionmentioning

confidence: 99%

Blood pressure as prognostic marker for body condition, cardiovascular, and metabolic diseases in the common marmoset (Callithrix jacchus)

Mietsch

Baldauf

Reitemeier

et al. 2016

J of Medical Primatology

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Spontaneous glomerular mesangial lesions in common marmoset monkeys (Callithrix jacchus): a benign non‐progressive glomerulopathy

Abstract: Marmosets develop a glomerulopathy characterized by mesangial expansion, IgM deposition, and proteinuria. This is a benign occurrence and not specifically associated with weight loss.

Cited by 18 publications

References 41 publications

Cross‐sectional comparison of health‐span phenotypes in young versus geriatric marmosets

Cross‐sectional comparison of health‐span phenotypes in young versus geriatric marmosets

A qualitative investigation of HIV treatment dispensing models and impacts on adherence among people living with HIV who use drugs

Blood pressure as prognostic marker for body condition, cardiovascular, and metabolic diseases in the common marmoset (Callithrix jacchus)

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