Abstract:We encountered hematolymphoid neoplastic lesions in the form of many nodules in the
spleen and liver in a 110-week-old male Wistar Hannover rat (Crl:WI (Han)). The lesions
contained atypical proliferative cells, eosinophils, lymphocytes, and macrophages. The
proliferative cells comprised various atypical cell types with or without cytoplasmic
eosinophilic granules. The granules were positively stained using periodic acid-Schiff and
elastase stains, were bluish purple using phosphotungstic acid and hematoxylin,… Show more
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