Spontaneous Gas Bubbling in Microporous Oxygenators

Karichev, Z. R.; Muler, A. L.; Vishnevsky, Michael E.

doi:10.1046/j.1525-1594.1999.06210.x

Cited by 5 publications

(3 citation statements)

References 1 publication

(3 reference statements)

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“…In addition, gas microbubbles can leak into the blood under certain conditions. 3 Thus, there are limitations to using polypropylene microporous membrane gas exchange devices for perfusion periods Ͼ 6 hours.…”

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confidence: 99%

A Polymethylpentene Fiber Gas Exchanger for Long-Term Extracorporeal Life Support

et al. 2005

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A polymethylpentene (PMP) fiber gas exchange device was evaluated in healthy sheep (35-42 kg) to characterize its performance and potential use in clinical extracorporeal life support (ECLS). Five PMP devices (1.3 m2) were compared with five silicone rubber membrane lung (SRML) devices (1.5 m2) that were supported on venovenous ECLS for 72 hours. The two device groups were compared for differences in gas exchange, device pressure gradient, hematology, blood biochemistry, and pathology. The results showed superiority in the PMP devices in both oxygen and CO2 exchange when compared at similar blood flow rates. Platelet consumption and the device pressure gradient were significantly less when using the PMP device. The device pressure gradient across the PMP devices was < 20 mm Hg as compared with > 150 mm Hg for the SRML devices at all blood flow rates. Changes in plasma hemoglobin levels, leukocyte counts, blood chemistry results, and pathologic findings were not significantly different between the two device groups. Plasma leakage or device failure did not occur in any of the test devices. These data support the use of the PMP device for extended circulatory support. Patients may fare better because of improved preservation of platelets, and the low resistance may allow for wider use of centrifugal-style pumps or the use of the device in a pumpless arteriovenous mode.

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confidence: 99%

A Polymethylpentene Fiber Gas Exchanger for Long-Term Extracorporeal Life Support

et al. 2005

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“…Spontaneous gas bubbling of membrane oxygenators can be related to the high hydraulic resistance of the very fine membrane pores to water vapours and gases dissolved in the blood. This increases the local gas pressure and causes bubble formation from the blood-gas interface into the membrane pores [19]. This mechanism can be increased during the pulsed flow for the greater kinetic energy through the membrane micropores.…”

Section: Discussionmentioning

confidence: 99%

Pulsatile flow decreases gaseous micro-bubble filtering properties of oxygenators without integrated arterial filters during cardiopulmonary bypass

Milano

Dodonov

Menon

et al. 2013

Interact CardioVasc Thorac Surg

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“…46 Spontaneous gas bubbling may occur in membrane oxygenators with microporous membrane, and when the priming procedure of the device is carried out in an inappropriate manner. 47…”

Section: Micro Airmentioning

confidence: 99%

Prebypass filtration of cardiopulmonary bypass circuits: an outdated technique?

2003

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Filtration of cardiopulmonary bypass (CPB) priming fluid before connection of the circuit to the patient was first accomplished by arterial line filtration. When dedicated prebypass filters (PBFs) with smaller pore sizes became available, a large number of particles could be found on the filter surface. In recent years, modern manufacturing methods for CPB circuit components were believed to be associated with a reduced number of particles found in components of extracorporeal circuits, making separate filtration of CPB priming solution unnecessary. Microemboli generated during the preparation and priming procedure of the CPB circuit may consist of either solid particles or gaseous emboli and may contribute to patient morbidity. Endotoxins found in infusion solutions and CPB priming solutions may trigger inflammatory responses when administered into the circulatory system. Filtration of crystalloid CPB priming solutions with a PBF consisting of a filter membrane with a pore size of 0.2 microm was found to effectively reduce the number of microemboli. Infusion filters with a filter pore size of 0.2 microm were found to reduce the endotoxin contamination in infusion solutions. Prebypass filtration with filters containing pores of 0.2 pm should be a necessity for contemporary perfusion practice.

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Spontaneous Gas Bubbling in Microporous Oxygenators

Cited by 5 publications

References 1 publication

A Polymethylpentene Fiber Gas Exchanger for Long-Term Extracorporeal Life Support

A Polymethylpentene Fiber Gas Exchanger for Long-Term Extracorporeal Life Support

Pulsatile flow decreases gaseous micro-bubble filtering properties of oxygenators without integrated arterial filters during cardiopulmonary bypass

Prebypass filtration of cardiopulmonary bypass circuits: an outdated technique?

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