Spontaneous fatal recurrent tumor lysis syndrome in ductal breast carcinoma

Goyal, Hemant; Sawhney, Harinder; Singh, Jagmeet

doi:10.1016/j.cmonc.2012.03.004

Cited by 4 publications

(3 citation statements)

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“…When the liver is not involved, patients inevitably had a large tumor burden and necrosis. Sixteen cases of TLS in patients with breast cancer were identified [6][7][8][12][13][14][15][16][17][18][19][20][21][22]. The age of the patients ranged from 31 years to 94 years with the median age being 53 years.…”

Section: Discussionmentioning

confidence: 99%

“…The mortality rate of this Cordrey/Dienhart/Wang cohort was 69%. Thirteen patients (81%) had TLS after various treatment [12][13][14][15][16][17][18][19][20][21][22], while three (19%) patients had STLS prior to active cancer therapy [6][7][8]. The underling mechanisms and triggers for spontaneous TLS have not been well described.…”

Section: Discussionmentioning

confidence: 99%

“…TLS has been rarely described with nonhematologic solid tumors, and it is even more uncommon to have spontaneous tumor lysis syndrome (STLS) in solid tumors [2][3][4][5]. To our knowledge, only three previous STLS in metastatic breast cancer were reported in the literature [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spontaneous tumor lysis syndrome in a giant neglected breast cancer.

Cordrey¹,

Dienhart²,

Wang³

2018

molecular-oncology

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Tumor lysis syndrome (TLS) is an oncologic emergency that generally triggered by effective cytotoxic chemotherapy in a context of rapidly proliferating and chemo-sensitive tumor or in patients with massive tumor burden. TLS has been rarely described in patients with solid tumors, and it is even more uncommon to have spontaneous tumor lysis syndrome (STLS). To our knowledge, only three cases of STLS in metastatic breast cancer were reported in the literature. Herein, we present a new case of STLS in a 37-year-old female with giant neglected metastatic breast cancer. She subsequently developed acute oliguric renal failure and multiple electrolyte abnormalities requiring hemodialysis. Despite aggressive supportive care, the patient developed multiple organ failure and died eight days after admission. Our case highlights the importance of increased awareness of this rare but life threatening condition. TLS should be included in the differential diagnosis of patients with newly diagnosed breast cancer who present with acute kidney injury even before they receive any active cancer therapy

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