Spontaneous embryonic loss after in vitro fertilization with and without intracytoplasmic sperm injection

Sala, Giovanni Battista La; Nucera, Giuseppe; Gallinelli, Andrea; Nicoli, Alessia; Villani, Maria Teresa; Blickstein, Isaac

doi:10.1016/j.fertnstert.2004.04.062

Cited by 32 publications

(23 citation statements)

References 8 publications

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“…In the primary analysis of the same database, we found no difference between loss and/or survival rates of multiple gestations following conventional IVF or ICSI and suggested that other factors, such as embryo quality or uterine environment, might be involved in the outcome of multiple pregnancies following assisted reproduction (8).…”

Section: Discussionmentioning

confidence: 76%

“…The ethical committee of the hospital approved the study. The same database was used for other studies (5,8).…”

Section: Methodsmentioning

confidence: 99%

“…Finally, the data of two different studies show that the general trend does not consistently depend on maternal age (5,8).…”

Section: Introductionmentioning

confidence: 93%

“…Another explanation could attribute the advantage of multiples to the mode of conception, but the general observation, namely, a disadvantage for the early singleton pregnancies, was true for both ICSI and conventional IVF pregnancies (8). Finally, the data of two different studies show that the general trend does not consistently depend on maternal age (5,8).…”

Section: Introductionmentioning

confidence: 93%

“…When these women are exposed to assisted reproductive technologies (ART), they produce better embryos, have a greater chance for more implantations, and consequently -they have a higher probability of having a multiple gestation. Following our initial studies (5,8), we conducted a secondary analysis to determine whether the number of transferred embryos in different maternal age groups influence these early spontaneous embryonic losses. The unique circumstance resulting from the ART protocols used in Reggio Emilia, where all available embryos are transferred in each cycle (5,8) enables this evaluation.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Lower embryonic loss rates among twin gestations following assisted reproduction

Sala¹,

Nucera²,

Gallinelli³

et al. 2005

J Assist Reprod Genet

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Purpose : To determine whether maternal age and number of transferred embryos influence early pregnancy losses in twin pregnancies compared to singletons following IVF/ICSI. Methods : We compared the pregnancy loss rates in singleton (n = 549) and twin (n = 252) gestations, stratified by maternal age (≤35 and >35 years) and the number of transferred embryos (1-3 and 4-9). Results : Loss rates of singleton pregnancies were significantly higher than that in twins (OR 3.0, 95% CI 1.9, 4.9), especially among singletons conceived after transfer of 4-9 embryos (OR 5.0, 95% CI 2.2, 11.9). Younger mothers of twins had lower loss rates (OR 0.3, 95% CI 0.1, 0.9). Conclusion : Twins have a significantly reduced spontaneous miscarriage rate compared with singletons following IVF/ICSI. Higher implantation rates per cycle (i.e., development of twins rather than one live embryo) may represent a better capacity of the uterus for early embryonic development.

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Section: Discussionmentioning

confidence: 76%

“…The ethical committee of the hospital approved the study. The same database was used for other studies (5,8).…”

Section: Methodsmentioning

confidence: 99%

“…Finally, the data of two different studies show that the general trend does not consistently depend on maternal age (5,8).…”

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lower embryonic loss rates among twin gestations following assisted reproduction

Sala¹,

Nucera²,

Gallinelli³

et al. 2005

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

Should vanishing twin pregnancies be systematically excluded from cell‐free fetal DNA testing?

et al. 2020

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Objective To demonstrate the feasibility of cell‐free DNA (cfDNA) testing in vanishing twin (VT) pregnancies in routine clinical practice. Methods Our study included 24 874 singleton and 206 VT consecutive pregnancies. Cell‐free DNA was analyzed by massively parallel sequencing. Both aneuploidy analysis (chromosomes 13,18, 21, X, and Y) and fetal fraction estimation were performed according to an Illumina algorithm. Contaminant DNA contribution from the demised co‐twin was studied in detail. Results VT pregnancies exhibited a higher prevalence of screen‐positive cases (5.8% vs 2.5%), sex discrepancies (10.2% vs 0.05%), and false positive rates (FPR) (2.6% vs 0.3%) than singleton pregnancies. However, their incidence was significantly lower in tests performed after the 14th week (screen‐positive cases: 3.1%; sex discrepancies: 7.8%; and FPR: 0.8%). Among the 12 cases in which cfDNA was performed at two time points, fading of contaminating cfDNA was observed in four cases with a sex discrepancy and in one false positive for trisomy 18, resulting in a final correct result. Conclusions Our data suggest VT pregnancies could be included in cfDNA testing as long as it is applied after the 14th week of pregnancy. However, future studies to validate our findings are needed before including VT cases in routine clinical practice. Once established, unnecessary invasive procedures could be avoided, mitigating negative emotional impact on future mothers.

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Associated perinatal determinants of vanishing twin pregnancies achieved by in vitro fertilization vs. spontaneous conception

Márton

Zádori

Keresztúri

et al. 2020

Arch Gynecol Obstet

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Spontaneous embryonic loss after in vitro fertilization with and without intracytoplasmic sperm injection

Cited by 32 publications

References 8 publications

Lower embryonic loss rates among twin gestations following assisted reproduction

Lower embryonic loss rates among twin gestations following assisted reproduction

Should vanishing twin pregnancies be systematically excluded from cell‐free fetal DNA testing?

Associated perinatal determinants of vanishing twin pregnancies achieved by in vitro fertilization vs. spontaneous conception

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