Spontaneous echo contrast of unexpected etiology

Şerban, Marinela; Ghiorghiu, Ioana; Craciunescu, I.; Calin, Cosmin; Platon, Pavel; Apetrei, Eduard; Ginghină, Carmen

doi:10.1016/j.euje.2005.05.007

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…There is increasing evidence suggesting that miRNAs play critical roles in many key biological processes, such as cell growth, tissue differentiation, cell proliferation, embryonic development, cell proliferation, and apoptosis [ 34 ]. Aberrant expression of miRNAs including mutation, dysfunction, and dysregulation of miRNAs and their targets may result in various diseases, such as cancers [ 34 , 35 ], cardiovascular disease [ 36 , 37 ], schizophrenia [ 38 , 39 ], psoriasis [ 40 ], and primary muscular disorders [ 41 ]. In the meantime, miRNAs have been great interest in utilizing miRNAs as a nonpharmaceutical approach to treat numerous diseases including HIV-1, HSV, Dengue, Influenza, and hepatitis C (HCV).…”

Section: Discussionmentioning

confidence: 99%

A Computational Approach for Predicting Role of Human MicroRNAs in MERS-CoV Genome

Hasan

Akter

Ullah

et al. 2014

Advances in Bioinformatics

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The new epidemic Middle East Respiratory Syndrome (MERS) is caused by a type of human coronavirus called MERS-CoV which has global fatality rate of about 30%. We are investigating potential antiviral therapeutics against MERS-CoV by using host microRNAs (miRNAs) which may downregulate viral gene expression to quell viral replication. We computationally predicted potential 13 cellular miRNAs from 11 potential hairpin sequences of MERS-CoV genome. Our study provided an interesting hypothesis that those miRNAs, that is, hsa-miR-628-5p, hsa-miR-6804-3p, hsa-miR-4289, hsa-miR-208a-3p, hsa-miR-510-3p, hsa-miR-18a-3p, hsa-miR-329-3p, hsa-miR-548ax, hsa-miR-3934-5p, hsa-miR-4474-5p, hsa-miR-7974, hsa-miR-6865-5p, and hsa-miR-342-3p, would be antiviral therapeutics against MERS-CoV infection.

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Section: Discussionmentioning

confidence: 99%

A Computational Approach for Predicting Role of Human MicroRNAs in MERS-CoV Genome

Hasan

Akter

Ullah

et al. 2014

Advances in Bioinformatics

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“…Whereas CTS in paediatric patients rarely is an incidental finding,29–33 40 this accounts for one of four adult patients with the non-obstructive membrane 15 17 21 47–4929.…”

Section: Discussionmentioning

confidence: 95%

“…Contrary to adults, AF is an uncommon finding in paediatric populations, where it is present in up to 4% of the cases 24 30–33. Some adults with obstructive membrane physiology may present with non-specific symptoms, such as haemorrhage, making this a challenging diagnosis 40–45…”

Section: Discussionmentioning

confidence: 99%

Cor triatriatum sinistrum diagnosed in the adulthood: a systematic review

Rudienė

Hjortshøj

Glaveckaitė

et al. 2019

Heart

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BackgroundWe performed a systematic review of cor triatriatum sinistrum (CTS) diagnosed in adults. The aim of this review was to describe the clinical presentation, natural history and management of this congenital heart disease.MethodsA PubMed literature search for ‘cor triatriatum sinistrum’ published since 2005 was performed. Included patients were divided into those with and without obstructive membrane physiology. The clinical course differences were compared.ResultsA total of 171 published cases were included. The median age at diagnosis was 43 years (IQR, 30–60). Obstructive membrane physiology was observed in 70 (41%), and this patient group was younger at presentation (median age 39 (IQR, 28–52) vs 50 years (IQR, 32–64), p=0.003).Patients with obstructive membrane more frequently had associated cardiac defects (58.6% vs 42.4%, p=0.039). Overall, the most frequent clinical symptom was atrial fibrillation, as this was present in 56 (32.8%) of all patients. CTS-related symptoms were more frequent in patients with obstructive membrane: congestive heart failure (44.3% vs 15.2%, p<0.001), pulmonary hypertension (27.1% vs 6.1%, p<0.001), haemorrhage (8.6% vs 0%, p=0.004) and infections manifestation (8.6% vs 0%, p=0.004).A total of 71 (41.5%) patients with CTS required interventional treatment, mainly within patients with the obstructive membrane (86.8% vs 12.6%, p<0.001).ConclusionThe natural history of CTS most often manifests with symptoms of congestive heart failure. Patients with obstructive membrane most often have associated cardiac defects and higher risk for infections and haemorrhage. The interventional treatment of CTS remains the first choice for obstructive membrane.

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“…In the past recent years, many reports have identified miRNAs as signature biomarkers that play a critical role in various cellular processes, such as cell proliferation, apoptosis, differentiation, and embryonic development [31]. Dysregulation in the expression status of miRNAs has been associated with several diseases including viral diseases, cancer [31,32], diabetes, schizophrenia [33,34], psoriasis [35], and cardiovascular disease [36].…”

Section: Mirnas In Sars Mers and Covid-19 Viral Diseasesmentioning

confidence: 99%

COVID-19: fighting the invisible enemy with microRNAs

Chauhan

Jaggi

Chauhan

et al. 2020

Expert Review of Anti-infective Therapy

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Introduction: The novel coronavirus (CoV) disease 2019 (COVID-19) is a viral infection that causes severe acute respiratory syndrome (SARS). It is believed that early reports of COVID-19 cases were noticed in December 2019 and soon after it became a global public health emergency. It is advised that COVID-19 transmits through human to human contact and in most cases, it remains asymptomatic. Several approaches are being utilized to control the outbreak of this fatal viral disease. microRNAs (miRNAs) are known signature therapeutic tool for the viral diseases; they are small non-coding RNAs that target the mRNAs to inhibit their post-transcriptional expression, therefore, impeding their functions, can serve as watchdogs or micromanagers in the cells. Areas covered: This review work delineated COVID-19 and its association with SARS and Middle East respiratory syndrome (MERS), the possible role of miRNAs in the pathogenesis of COVID-19, and therapeutic potential of miRNAs and their effective delivery to treat COVID-19. Expert opinion: This review highlighted the importance of various miRNAs and their potential role in fighting with this pandemic as therapeutic molecules utilizing nanotechnology.

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Spontaneous echo contrast of unexpected etiology

Cited by 4 publications

References 2 publications

A Computational Approach for Predicting Role of Human MicroRNAs in MERS-CoV Genome

A Computational Approach for Predicting Role of Human MicroRNAs in MERS-CoV Genome

Cor triatriatum sinistrum diagnosed in the adulthood: a systematic review

COVID-19: fighting the invisible enemy with microRNAs

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