Spontaneous coronary artery dissection treated with magnesium‐made bioresorbable scaffold: 1‐Year angiographic and optical coherence tomography follow‐up

Quadri, Giorgio; Cerrato, Enrico; Rolfo, Cristina; Varbella, Ferdinando

doi:10.1002/ccd.27971

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…Moreover, QFR assessment after PCI of culprit vessel in ACS may be influenced by subtended microvascular dysfunction secondary to myocardium infarction 25 . Overall, our results should be considered as hypothesis generating and not conclusive but contribute to extend current data on magnesium‐based resorbable sirolimus‐eluting scaffold performance in complex settings 26‐28 …”

Section: Limitationsmentioning

confidence: 82%

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Anatomical and functional healing after resorbable magnesium scaffold implantation in human coronary vessels: A combined optical coherence tomography and quantitative flow ratio analysis

Cerrato

Belliggiano

Quadri

et al. 2020

Cathet Cardio Intervent

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Background: No data are currently available on the process of vessel healing and long-term physiological results after implantation of resorbable magnesium-made scaffold (RMS) in human coronary arteries.Objectives: To investigate after percutaneous coronary intervention (PCI) and at 12 months follow-up (a) RMS resorption process and vessel healing, as judged by optical coherence tomography (OCT) imaging; and (b) physiological result of RMS implantation evaluated by quantitative flow ratio (QFR).Methods: All patients successfully treated with at least one RMS from July 2016 to August 2018 at 2 Italian centers were evaluated. All cases with OCT pullback and/or coronary angiography suitable for QFR analysis performed after PCI and at 12 months were included. Resorption process was analyzed at OCT in each frame reporting presence of residual struts in the vessel.Results: Forty-four patients/forty-nine lesions were included. 12-months mean lumen area (LA; 7.54 ± 3.04 mm 2 ) significantly decreased compared to mean LA recorded immediately after PCI (8.12 ± 1.89 mm 2 ; p < .01). However, LA changes did not affect the functional result of PCI with a non-ischemic QFR value (>0.80) in 98% of cases at 12-months follow-up. Protruding struts were detectable in more than half of cases and their presence was correlated with an increase in mean LA (+0.73mm 2 [95% CI 0.51-0.94], p < .001).Conclusions: RMS implantation in a real-world population lead to significant decrease in mean LA without significant functional impairment. Two different patterns of RMS resorption were recorded, whose clinical significance remains to be investigated.

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Section: Limitationsmentioning

confidence: 82%

“…25 Overall, our results should be considered as hypothesis generating and not conclusive but contribute to extend current data on magnesium-based resorbable sirolimus-eluting scaffold performance in complex settings. [26][27][28] 6 | CONCLUSION…”

Section: Discussionmentioning

confidence: 99%

Anatomical and functional healing after resorbable magnesium scaffold implantation in human coronary vessels: A combined optical coherence tomography and quantitative flow ratio analysis

Cerrato

Belliggiano

Quadri

et al. 2020

Cathet Cardio Intervent

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“…Ongoing clinical trials (MAGSTEMI) are, however, evaluating the performance of Magmaris in STEMI patients in comparison with Orsiro. Regarding other acute coronary syndrome settings, a recent case report suggests the possibility to take advantage of resorbable magnesium scaffold to treat spontaneous coronary dissection, in order to obtain long-term restoration of coronary vasomotion [58,59]. Finally, patients who cannot comply with current ESC/EAPCI DAPT recommendations for stable lesions must not be treated with Magmaris scaffold [14].…”

Section: When Should I Place a Magmaris Scaffold?mentioning

confidence: 99%

Magmaris™ Resorbable Magnesium Scaffold: state-of-art Review

et al. 2019

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Bioresorbable scaffolds (BRS) have been advocated as the ‘fourth revolution’ in interventional cardiology because they could provide temporary scaffolding and then ‘disappear’ (resorb) potentially significantly improving coronary artery disease treatment. BRS technology has gradually matured, and there are many devices available worldwide, which are currently undergoing preclinical or clinical testing. Due to the concerns related to polylactide scaffolds, magnesium alloy is now one of the most promising resorbable technologies despite available evidences on its performances in vivo are limited to small observational studies. In this state-of-art review we present Magmaris™ (Biotronik AG, Buelach, Switzerland) magnesium-based BRS from bench to bedside, reviewing to date available clinical trial data and current recommendations for its optimal use in clinical practice.

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“…The last but not the least, intracoronary imaging may be used during follow-up in case of implant of a bio-resorbable scaffold in order to assess the complete resorption of the device 32 , a promising technique that may help to take care of the SCAD without leaving permanent stents in young patients.…”

Section: Follow-upmentioning

confidence: 99%

Role of Invasive and Non-invasive Imaging Tools in the Diagnosis and Optimal Treatment of Patients with Spontaneous Coronary Artery Dissection

et al. 2019

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The latest advances in imaging technology have provided cardiologists with additional tools to help dealing challenging scenarios. A perfect example of such cases is represented by Spontaneous Coronary Artery Dissection (SCAD), which is often difficult to recognize and whose interventional treatment is not free from complications. New techniques, such as IVUS, OCT or CCTA, have improved our ability to confirm doubtful cases of SCAD, optimize the interventional strategy and properly monitor patients after discharge. Hence, in the present review, we discuss the main imaging tools employed in SCAD cases, introducing their advantages and drawbacks and focusing on the different role they may play in SCAD diagnosis, management and follow-up

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Spontaneous coronary artery dissection treated with magnesium‐made bioresorbable scaffold: 1‐Year angiographic and optical coherence tomography follow‐up

Abstract: A young woman admitted with a diagnosis of NSTE‐ACS underwent coronary angiography which showed LAD spontaneous coronary artery dissection treated with magnesium‐made bioresorbable scaffold. We report 1‐year angiographic and OCT findings.

Cited by 7 publications

References 15 publications

Anatomical and functional healing after resorbable magnesium scaffold implantation in human coronary vessels: A combined optical coherence tomography and quantitative flow ratio analysis

Anatomical and functional healing after resorbable magnesium scaffold implantation in human coronary vessels: A combined optical coherence tomography and quantitative flow ratio analysis

Magmaris™ Resorbable Magnesium Scaffold: state-of-art Review

Role of Invasive and Non-invasive Imaging Tools in the Diagnosis and Optimal Treatment of Patients with Spontaneous Coronary Artery Dissection

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