Spontaneous Complete Remission in a Patient with Acute Myeloid Leukemia and Severe Sepsis

Mozafari, Rambod; Moeinian, Mahsa; Asadollahi–Amin, Ali

doi:10.1155/2017/9593750

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…In fact, in one study, up to 72% of patients who presented to the hospital at one institution with de novo AML had a concomitant fever at presentation [15]. In addition, there have been several case reports with patients who had an SR of their AML without a preceding infection, making it unlikely that infection alone could explain all cases of SR of AML [2][3][4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…It was first described in the literature by Eisenlohr in 1878 after a patient had regression of "marked leukocytosis" after a severe typhoid infection [1]. More recently, Rashidi and Fisher reviewed 46 cases of SR of AML from 1951 to 2014 and there have been several other case reports since 2014 describing this phenomenon [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous Remission in a Patient With Acute Myeloid Leukemia Leading to Undetectable Minimal Residual Disease

et al. 2020

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Although rare, spontaneous remission (SR) of acute myeloid leukemia (AML) has been reported in the literature, the underlying mechanisms driving remission remain unknown. However, it is most commonly associated with a preceding severe infection. We present a case of a 40-year-old man with no past medical history who presented to our hospital with severe left hip pain and fevers and was found to have AML. Chemotherapy was delayed because the patient required extensive debridement and fasciotomy of his left hip and a prolonged course of antibiotics. After his acute illness had stabilized, a repeat bone marrow biopsy was performed which showed no abnormal myeloid blasts and resolution of his original cytogenetic and molecular abnormalities. At the time of this writing, our patient remains in remission with undetectable minimal residual disease (MRD), now 14 months from his initial diagnosis of AML.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spontaneous Remission in a Patient With Acute Myeloid Leukemia Leading to Undetectable Minimal Residual Disease

et al. 2020

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“…Prolonged Spontaneous remission of cancer has been reported after pneumonia [1], pulmonary edema [2], hemorrhage [3,4] low hemoglobulin [5], Tumor hypoxia (occlusion of hepatic artery or portal vein) [6], nephrectomy in the presence of pulmonary metastases [7][8][9][10], liver cirrhosis [11,12], jaundice [2,13] biopsy [14][15][16][17], etc. All have in common a low blood oxygen delivery to the tumor.…”

Section: Resultsmentioning

confidence: 99%

Proposed Biology of the Spontaneous Remission of Cancer

Behzad¹

2021

Int J Cancer Clin Res

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Two common factors were identified among the case reports of the prolonged spontaneous remission and regression of cancer. The prolonged spontaneous remissions of cancer may be preceded by a low blood oxygen delivery to the tumor and a short, steady or rapid malignant growth. The steady or rapid growth of primary tumor not the growth of new metastases. HypotHeses Check for updatesSpontaneous remission of renal cell carcinoma may occur more commonly after nephrectomy in patients with pulmonary metastases. Spontaneous remissions of leukemia may occur more commonly after pneumonia. Spontaneous remission of Merkel cell carcinoma may occur more commonly after biopsy, etc. It is interesting that these specific events are not specific to a type of cancer, they may occur in different types of cancer. Yet, they have a higher propensity in certain types of cancer. A common denominator was sought.The etiology of the spontaneous regression or remission of cancer is unknown. Theories regarding the pathophysiology of the spontaneous regression or remission of cancer vary. It might be attributed to an immune activation, withdrawal of a possible causative agent, hormonal change, change in blood supply, cell apoptosis, tumor necrosis, infection, cytokines, chemokines, herbal remedies, etc. this study suggest that a steady or rapid growth of primary tumor faced with a low blood oxygen may result in a spontaneous regression or remission of cancer. MethodsDifferent disciplines related to cancer were studied such as biology, immunology, endocrinology, neurology, etc. as it relates to cancer. Later focus was made on the reported cases of the spontaneous regression or remission of cancer. Case Reports of the spontaneous remission and regression of cancer since the late 1800's was studied. They were classified as short and temporary or prolonged remissions. Afterwards the case reports of prolonged spontaneous remissions or regressions of cancer were classified by tissue type and events preceding the spontaneous regression or remission of cancer. The events most commonly preceding each

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“…SR of AML is a relatively rare phenomenon in which the underlying mechanisms are not precisely known. Although based on existing published data, an immune-dependent mechanism secondary to the infectious process is considered the probable leading cause of SR [5][6][7], the other possible factors such as transfusion of blood products, corticosteroids, and colchicine that may contribute to the induction of remission in our case should be considered and discussed.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Complete Remission of Acute Myeloid Leukemia in the Absence of Disease-Modifying Therapy following Severe Pulmonary Involvement by Coronavirus Infectious Disease-19

Barkhordar

Rostami

Yaghmaie

et al. 2022

Case Reports in Hematology

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Coronavirus infectious disease-19 (COVID-19) usually alters the innate and adaptive immune setting by excessive production of proinflammatory cytokines, leading to a deviation in the natural course of simultaneous malignant disease. In the absence of disease-modifying therapy, complete remission of acute myeloid leukemia (AML) is an extraordinary event caused mainly by an immune-related mechanism secondary to a severe infectious process. We present a 57-year-old woman with a new diagnosis of AML associated with a 11q23/KMT2A abnormality who had achieved temporary spontaneous remission in the absence of disease-modifying therapy following the severe pulmonary infection with coronavirus lasting for six months. We review the literature and explain the potential impact of stimulated immune responses by COVID-19 on induction of remission in a patient with AML that could provide an excellent opportunity for new immune-based therapies to evolve for the hematologic malignancies. Despite the high ability of the immune process to destroy the malignant cells, the remission of duration is usually short. Therefore, it seems that continuing treatment after SR of AML by a consolidation regimen or bone marrow transplantation, based on a risk-adapted treatment approach, may reduce the recurrence risk.

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Spontaneous Complete Remission in a Patient with Acute Myeloid Leukemia and Severe Sepsis

Cited by 8 publications

References 9 publications

Spontaneous Remission in a Patient With Acute Myeloid Leukemia Leading to Undetectable Minimal Residual Disease

Spontaneous Remission in a Patient With Acute Myeloid Leukemia Leading to Undetectable Minimal Residual Disease

Proposed Biology of the Spontaneous Remission of Cancer

Spontaneous Complete Remission of Acute Myeloid Leukemia in the Absence of Disease-Modifying Therapy following Severe Pulmonary Involvement by Coronavirus Infectious Disease-19

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