Spontaneous closure of muscular trabecular ventricular septal defect: comparison of defect positions

Miyake, Toshiharu; Shinohara, T; Inoue, Tomohiro; Marutani, Satoshi; Takemura, Tsukasa

doi:10.1111/j.1651-2227.2011.02333.x

Cited by 15 publications

(14 citation statements)

References 24 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whether the site of muscular defects affects the probability of a spontaneous closure is a controversial issue. In older studies, apical defects seemed to be the most prone to closure; more recent reports showed that mid‐ventricular defects had a higher probability of closing . In our experience, among muscular VSD at 2‐year follow‐up the probability of spontaneous closure was higher for central type compared to apical and marginal type ( P = .003 and P = .006, respectively; Table ), whereas at 6‐year follow‐up no more statistical differences were present ( P = .6).…”

Section: Discussionmentioning

confidence: 45%

“…In our experience, among muscular VSD at 2‐year follow‐up the probability of spontaneous closure was higher for central type compared to apical and marginal type ( P = .003 and P = .006, respectively; Table ), whereas at 6‐year follow‐up no more statistical differences were present ( P = .6). A reduction of the probability of spontaneous closure after the second year of life has been recently reported by Xu et al, although the possibility of closure until adolescence and even in adult life are described …”

Section: Discussionmentioning

confidence: 83%

See 1 more Smart Citation

Incidence and natural history of neonatal isolated ventricular septal defects: Do we know everything? A 6-year single-center Italian experience follow-up

Cresti

Giordano

Koestenberger

et al. 2017

Congenital Heart Disease

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 83%

Incidence and natural history of neonatal isolated ventricular septal defects: Do we know everything? A 6-year single-center Italian experience follow-up

Cresti

Giordano

Koestenberger

et al. 2017

Congenital Heart Disease

View full text Add to dashboard Cite

show abstract

“…It was reported that the defects with diameter ≤3 mm (3), <4 mm (12) or <5 or 6 mm (7) were more likely to close spontaneously. Th e size of the defect has also been suggested to aff ect the incidence of spontaneous VSD closure, particularly in muscular VSD (2,3,13). Th e incidence of closure varies with the site of the defect, with a closure rate of 83% in the anterior, 84% in the apical, and 89% in the mid-ventricular septum (13).…”

Section: Incidence Of Spontaneous Vsd Closurementioning

confidence: 99%

“…Th e size of the defect has also been suggested to aff ect the incidence of spontaneous VSD closure, particularly in muscular VSD (2,3,13). Th e incidence of closure varies with the site of the defect, with a closure rate of 83% in the anterior, 84% in the apical, and 89% in the mid-ventricular septum (13). However, there has been a huge controversy over the eff ects of the defect size on the incidence.…”

Section: Incidence Of Spontaneous Vsd Closurementioning

confidence: 99%

“…However, there has been a huge controversy over the eff ects of the defect size on the incidence. Although spontaneous closure of muscular VSD is more frequent in a mid-ventricular defect than an anterior or apical defect (13), apical defects are a preferable location for the closure (2). In addition, there have been no signifi cant differences in spontaneous closure between the mid-muscular and apical defects, although spontaneous closure of apical defects is frequently present (3).…”

Section: Incidence Of Spontaneous Vsd Closurementioning

confidence: 99%

See 1 more Smart Citation

A Review of Spontaneous Closure of Ventricular Septal Defect

Zhang¹,

Ko²,

Guileyardo³

et al. 2015

Baylor University Medical Center Proceedings

View full text Add to dashboard Cite

516Ventricular septal defect (VSD) is the most common congenital heart malformation and can be detected during the prenatal and postnatal period, in childhood, and in adulthood. Spontaneous closure of VSD can be determined through a variety of methods-echocardiography, Doppler color flow imaging, angiography, auscultation, and cardiac catheterization-and can be proven by pathological evidence at necropsy. There are two major types of VSD, membranous and muscular, as well as the perimembranous variety, which comprises variable portions of the adjacent muscular septum but lacks the membranous septum. VSD appears either as an isolated cardiac defect without other abnormalities or with several complex malformations. It has long been recognized that VSD can close spontaneously, but the incidence of spontaneous VSD closure is still uncertain. Since necropsy study of the hearts with VSD has rarely been reported, information on morphological features of spontaneous VSD closure remains limited. In addition, the mechanisms for spontaneous VSD closure are not fully understood. Herein, we present a brief review of the incidence of spontaneous VSD closure, morphological characteristics of the closure, and the main mechanisms responsible for the closure. INCIDENCE OF SPONTANEOUS VSD CLOSURETh e incidence of spontaneous ventricular septal defect (VSD) closure varies greatly, depending on the age and gender of subjects at spontaneous closure, the size and site of the defect, the types of defect, as well as the population studied, methods employed, and length of follow-up period. Table 1 presents available data on the incidence of spontaneous VSD closure.Age and gender. Age has been found to have a significant infl uence on the incidence of spontaneous VSD closure, whereas gender seems less likely to aff ect the incidence. Although spontaneous VSD closure can occur at any agegestation, infancy, childhood, adolescence, and adulthood (1)-it occurs most commonly during the fi rst 6 months of life (2), during the fi rst year (3, 4), or soon after the fi rst year of life (5). Afterward, the occurrence of closure declines progressively and occurs less commonly after the age of 10 (5). It has been documented that the incidence of the close increases with age, from 24% at 18 months of age to 50% at 48 months and 75% at 120 months (6). However, in older children, at 3.5 years old, the incidence declines sharply to 44% and then rises to 66% at 7 years and 75% at 10.5 years (6). A similar trend has been found in other reports, which showed 57% (109/190) of cases closed before 3 years of age, 89% (169/190) closed before 8 years of age (7), and 4% to 10% closed after the age of 17 (8, 9). During adulthood, the incidence of spontaneous VSD closure remarkably declines. One study showed that of 188 adults with VSD, 19 patients' (10%) VSD closed spontaneously between the age of 17 and 45 years, and the incidence of closure was greater in the 17-to 24-year age group than the 25-to 34-year group, the 35-to 44-year group, and the ≥45-year group (8)...

show abstract

Prediction of spontaneous closure of ventricular septal defect and guidance for clinical follow‐up

Ren

Song

et al. 2019

Clinical Cardiology

View full text Add to dashboard Cite

Aim To predict the spontaneous closure of ventricular septal defect (VSD) and assist pediatrician to manage VSD children. Methods Between January 2008 and December 2016, 132 children diagnosed with isolated VSD by echocardiography were enrolled. All participating children were followed‐up by echocardiography yearly until the closure of VSD or 6 years old. The clinical indicators and echocardiographic parameters of patients were collected. Statistically significant factors were used to establish a Logistic Regression model for predicting spontaneous closure of VSD. Receiver operating characteristic (ROC) analysis was used to assess the specificity and sensitivity of Logistic Regression model. Results Spontaneous closure occurred in 60% of all patients; 57% in perimembranous VSD (p‐VSD) and 64% in muscular VSD (m‐VSD) patients. Initial diagnosis age, defect size, aneurysms tissue of the ventricular membranous septum (ATVMS), pulmonary hypertension (PH), and left ventricular diastolic dimension (LVDD) were statistically significant. Defect size, ATVMS and LVDD were determined by the Logistic Regression model as representative factor. P‐VSD and m‐VSD model had areas under the ROC curves 0.854 and 0.898, respectively. Conclusion We inferred that defect size, ATVMS and LVDD were characteristic and representative predictors for spontaneous closure of VSD. And we summarized the prognostic factors and recommended a follow‐up criteria to assist the pediatrician managing VSD children.

show abstract

Spontaneous closure of muscular trabecular ventricular septal defect: comparison of defect positions

Abstract: We infer that midventricular muscular trabecular VSD tends to close spontaneously earlier and more frequently than either anterior or apical muscular trabecular VSD.

Cited by 15 publications

References 24 publications

Incidence and natural history of neonatal isolated ventricular septal defects: Do we know everything? A 6-year single-center Italian experience follow-up

Incidence and natural history of neonatal isolated ventricular septal defects: Do we know everything? A 6-year single-center Italian experience follow-up

A Review of Spontaneous Closure of Ventricular Septal Defect

Prediction of spontaneous closure of ventricular septal defect and guidance for clinical follow‐up

Contact Info

Product

Resources

About