Spontaneous C. septicum gas gangrene: A literature review

Srivastava, Ira; Aldape, Michael J.; Bryant, Amy E.; Stevens, Dennis L.

doi:10.1016/j.anaerobe.2017.07.008

Cited by 53 publications

(62 citation statements)

References 84 publications

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“…Gas gangrene is known as an exogenous disease in which the agent enter the body throughout skin abrasions. Because C. septicum is an opportunistic pathogen, it can also cause gas gangrene endogenously, especially in immunosuppressed animals [14]. No skin abrasions were noted in the clinical examination of the animals in the present study.…”

Section: Discussionmentioning

confidence: 54%

Sudden death due to gas gangrene caused by Clostridium septicum in goats

et al. 2018

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BackgroundEven though gas gangrene caused by Clostridium septicum in goats is mentioned in the classical textbooks, we have not managed to find any case description in the literature.Case presentationClinical signs resembling gas gangrene such as subcutaneous bloating, edema and crepitation were detected at various body parts of nine pregnant animals at the ages of 2–3 years on a hair goat farm (n = 170) located in Bingol province, Eastern Turkey. Five of these suspected animals with severe clinical symptoms died within 2 days. Various samples such as internal organs, edematous skin and edema fluid collected from dead and live animals were analyzed for the presence of clostridial agents by histopathological and microbiological methods. As a result of macroscopic and microscopic examination, lesions of gas gangrene were detected. The suspected isolates were identified and confirmed as C. septicum by bacteriological and molecular methods.ConclusionThe present study was the first to report identification of C. septicum as primary agent in the gas gangrene of goats.

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Section: Discussionmentioning

confidence: 54%

Sudden death due to gas gangrene caused by Clostridium septicum in goats

et al. 2018

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“…Our patient had a monomicrobial infection with Clostridium septicum , a gram-positive anaerobe. Clostridium septicum NF has been linked with underlying malignancy, particularly colon cancer and hematological malignancies [ 30 ]. In a recent review, 61% of adult patients with Clostridium septicum NF had gastrointestinal malignancies [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature

Abdulkareem

D’Souza

Shogbesan

et al. 2017

Case Reports in Hematology

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Necrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to Clostridium septicum 7 weeks after treatment with rituximab. Despite immediate intravenous antimicrobial therapy and emergent fasciotomy with extensive debridement, his hospital course was complicated by septic shock and he required an above-the-knee amputation. Physicians need to be aware of the possibility of necrotizing fasciitis in patients presenting with skin infections after rituximab therapy.

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“…C. septicum may cause spontaneous, nontraumatic gas gangrene [34], and C. sordellii may induce gas gangrene of the uterus, as a consequence of spontaneous abortion, normal vaginal delivery, and traumatic injury [35]. As illustrated in Figure 17, C. butyricum happened to infect the stomach, resulting in fulminant death of a male patient aged 60's.…”

Section: Nontraumatic Gas Gangrenementioning

confidence: 99%

Pathology of Gangrene

Tsutsumi¹

2020

Pathogenic Bacteria

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Pathological features of gangrene are described. Gangrene is commonly caused by infection of anaerobic bacteria. Dry gangrene belongs to noninfectious gangrene. The hypoxic/ischemic condition accelerates the growth of anaerobic bacteria and extensive necrosis of the involved tissue. Clostridial and non-clostridial gangrene provokes gas formation in the necrotic tissue. Acute gangrenous inflammation happens in a variety of tissues and organs, including the vermiform appendix, gallbladder, bile duct, lung, and eyeball. Emphysematous (gas-forming) infection such as emphysematous pyelonephritis may be provoked by Escherichia coli and Klebsiella pneumoniae. Rapidly progressive gangrene of the extremities (so-called “flesh-eating bacteria” infection) is seen in fulminant streptococcal, Vibrio vulnificus, and Aeromonas hydrophila infections. Fournier gangrene is an aggressive and life-threatening gangrenous disease seen in the scrotum and rectum. Necrotizing fasciitis is a subacute form of gangrene of the extremities. Of note is the fact that clostridial and streptococcal infections in the internal organs may result in a lethal hypercytokinemic state without association of gangrene of the arms and legs. Uncontrolled diabetes mellitus may play an important role for vulnerability of the infectious diseases. Pseudomonas-induced malignant otitis externa and craniofacial mucormycosis are special forms of the lethal gangrenous disorder.

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Spontaneous C. septicum gas gangrene: A literature review

Cited by 53 publications

References 84 publications

Sudden death due to gas gangrene caused by Clostridium septicum in goats

Sudden death due to gas gangrene caused by Clostridium septicum in goats

A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature

Pathology of Gangrene

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