Spontaneous Breathing with Biphasic Positive Airway Pressure Attenuates Lung Injury in Hydrochloric Acid–induced Acute Respiratory Distress Syndrome

Xia, Jingen; Zhang, Heng; Sun, Bing; He, Hangyong; Zhan, Qingyuan

doi:10.1097/aln.0000000000000259

Cited by 19 publications

(23 citation statements)

References 44 publications

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“…The first line of defense against ROS mediated oxidative stress injury involved endogenous antioxidant enzymes such as SOD, GPx and CAT [4], [33]. Moreover, plasma levels of TNF-α and IL-6 were measured as indicators of systemic inflammatory responses [34], [35]. In our study, the activities of SOD, GPx and CAT were significantly decreased in LPS induced groups, accompanied with the increased MDA contents as well as the higher levels of TNF-α and IL-6.…”

Section: Discussionmentioning

confidence: 99%

Role of Nrf2/ARE Pathway in Protective Effect of Electroacupuncture against Endotoxic Shock-Induced Acute Lung Injury in Rabbits

Shi

Gong

et al. 2014

PLoS ONE

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NF-E2 related factor 2 (Nrf2) is a major transcription factor and acts as a key regulator of antioxidant genes to exogenous stimulations. The aim of current study was to determine whether Nrf2/ARE pathway is involved in the protective effect of electroacupuncture on the injured lung in a rabbit model of endotoxic shock. A dose of lipopolysaccharide (LPS) 5 mg/kg was administered intravenously to replicate the model of acute lung injury induced by endotoxic shock. Electroacupuncture pretreatment was handled bilaterally at Zusanli and Feishu acupoints for five consecutive days while sham electroacupuncture punctured at non-acupoints. Fourty anesthetized New England male rabbits were randomized into normal control group (group C), LPS group (group L), electroacupuncture + LPS group (group EL) and sham electroacupuncture + LPS (group SEL). At 6 h after LPS administration, the animals were sacrificed and the blood samples were collected for biochemical measurements. The lungs were removed for calculation of wet-to-dry weight ratios (W/D), histopathologic examination, determination of heme oxygenase (HO)-1 protein and mRNA, Nrf2 total and nucleoprotein, as well as Nrf2 mRNA expression, and evaluation of the intracellular distribution of Nrf2 nucleoprotein. LPS caused extensive morphologic lung damage, which was lessened by electroacupuncture treatment. Besides, lung W/D ratios were significantly decreased, the level of malondialdehyde was inhibited, plasma levels of TNF-α and interleukin-6 were decreased, while the activities of superoxide dismutase, glutathione peroxidase and catalase were enhanced in the electroacupucnture treated animals. In addition, electroacupuncture stimulation distinctly increased the expressions of HO-1 and Nrf2 protein including Nrf2 total protein and nucleoprotein as well as mRNA in lung tissue, while these effects were blunted in the sham electroacupuncture group. We concluded that electroacupuncture treatment at ST36 and BL13 effectively attenuates lung injury in a rabbit model of endotoxic shock through activation of Nrf2/ARE pathway and following up-regulation of HO-1 expression.

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Section: Discussionmentioning

confidence: 99%

Role of Nrf2/ARE Pathway in Protective Effect of Electroacupuncture against Endotoxic Shock-Induced Acute Lung Injury in Rabbits

Shi

Gong

et al. 2014

PLoS ONE

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“…The average interalveolar septum thickness was quantified in a blinded fashion by measuring the thickness of all septae along a crosshair placed on each image (at least 100 septae were measured per animal). Lung injury score was observed for quantification of the lung damage; briefly, images were evaluated by an investigator who was blinded to the identity of the slides (WCL) according to a previously defined scoring system [28]. The grading system was as follows: 0, minimal damage; 1, mild damage; 2, moderate damage; 3, severe damage; and 4, maximal damage.…”

Section: Methodsmentioning

confidence: 99%

Mesenchymal stromal cell treatment prevents H9N2 avian influenza virus-induced acute lung injury in mice

et al. 2016

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BackgroundThe avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory response syndrome and pulmonary infection in animals and humans. There are currently no specific treatment strategies for avian influenza.MethodsWe hypothesized that mesenchymal stromal cells (MSCs) would have beneficial effects in the treatment of H9N2 AIV-induced acute lung injury in mice. Six- to 8-week-old C57BL/6 mice were infected intranasally with 1 × 104 MID50 of A/HONG KONG/2108/2003 [H9N2 (HK)] H9N2 virus to induce acute lung injury. After 30 min, syngeneic MSCs were delivered through the caudal vein. Three days after infection, we measured the survival rate, lung weight, arterial blood gas, and cytokines in both bronchoalveolar lavage fluid (BALF) and serum, and assessed pathological changes to the lungs.ResultsMSC administration significantly palliated H9N2 AIV-induced pulmonary inflammation by reducing chemokines and proinflammatory cytokines levels, as well as reducing inflammatory cell recruit into the lungs. Thus, H9N2 AIV-induced lung injury was markedly alleviated in mice treated with MSCs. Lung histopathology and arterial blood gas analysis were improved in mice with H9N2 AIV-induced lung injury following MSC treatment.ConclusionsMSC treatment significantly reduces H9N2 AIV-induced acute lung injury in mice and is associated with reduced pulmonary inflammation. These results indicate a potential role for MSC therapy in the treatment of clinical avian influenza.

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“…Spontaneous breathing (SB) has been shown to have several beneficial effects such as the improved ventilation-perfusion matching, decreased muscle atrophy and decreased ventilator-induced lung injury (VILI) [3,4].…”

Section: Introductionmentioning

confidence: 99%

Ventilation-induced lung injury exists in spontaneously breathing patients with acute respiratory failure: No

Antonelli

2017

Intensive Care Med

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Spontaneous Breathing with Biphasic Positive Airway Pressure Attenuates Lung Injury in Hydrochloric Acid–induced Acute Respiratory Distress Syndrome

Abstract: In hydrochloric acid-induced acute respiratory distress syndrome, SB with BIPAP attenuated lung injury and improved respiratory function compared with controlled ventilation with low tidal volume.

Cited by 19 publications

References 44 publications

Role of Nrf2/ARE Pathway in Protective Effect of Electroacupuncture against Endotoxic Shock-Induced Acute Lung Injury in Rabbits

Role of Nrf2/ARE Pathway in Protective Effect of Electroacupuncture against Endotoxic Shock-Induced Acute Lung Injury in Rabbits

Mesenchymal stromal cell treatment prevents H9N2 avian influenza virus-induced acute lung injury in mice

Ventilation-induced lung injury exists in spontaneously breathing patients with acute respiratory failure: No

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