2017
DOI: 10.1038/s41598-017-16191-x
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Spontaneous body contractions are modulated by the microbiome of Hydra

Abstract: Spontaneous contractile activity, such as gut peristalsis, is ubiquitous in animals and is driven by pacemaker cells. In humans, disruption of the contraction pattern leads to gastrointestinal conditions, which are also associated with gut microbiota dysbiosis. Spontaneous contractile activity is also present in animals lacking gastrointestinal tract. Here we show that spontaneous body contractions in Hydra are modulated by symbiotic bacteria. Germ-free animals display strongly reduced and less regular contrac… Show more

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Cited by 69 publications
(71 citation statements)
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“…All multicellular animals emerged in a world that was already densely populated by microbes, and all extant animals are multiorganismal and colonized by a large number of symbiotic microbes. [43,44] Our recent studies demonstrate the existence of such communication in non-bilaterian animals as well, [24,37] and suggest a universal role of the nervous system in mediating host-microbe interactions throughout the Metazoa. [4] The emergence and evolution of the nervous system must be also considered in the context of host-microbe interactions.…”
Section: Rethinking the Role Of The Nervous Systemmentioning
confidence: 89%
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“…All multicellular animals emerged in a world that was already densely populated by microbes, and all extant animals are multiorganismal and colonized by a large number of symbiotic microbes. [43,44] Our recent studies demonstrate the existence of such communication in non-bilaterian animals as well, [24,37] and suggest a universal role of the nervous system in mediating host-microbe interactions throughout the Metazoa. [4] The emergence and evolution of the nervous system must be also considered in the context of host-microbe interactions.…”
Section: Rethinking the Role Of The Nervous Systemmentioning
confidence: 89%
“…[17]). The combination of diverse in vitro techniques, such as in situ hybridization, [20] immunofluorescence, [12] and electrophysiological measurements, [21,22] and recently developed in vivo imaging [23] and behavioral recordings, [24] promises deep insights into the molecular architecture and function of the nervous system in Hydra (for review see ref. [18,19] In addition to this conventional role in coordinating motor activities, the nervous system in Hydra appears to be orchestrating other organismal functions, such as development, tissue homeostasis, and immune function.…”
Section: Hydra Has a Simple Nervous Systemmentioning
confidence: 99%
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