Spontaneous Bacterial Peritonitis with Pasteurella Multocida in Cirrhosis: Case Report and Review of Literature

Abstract

Most Pasteurella multocida human infections involve skin and soft tissues and invariably develop after a bite or a scratch from a dog or a cat. However, other infections with this organism occur infrequently. Enteric microorganisms are the common cause of spontaneous bacterial peritonitis (SBP). We report a case of SBP in a cirrhotic patient from P. multocida. English literature (Pubmed) review revealed 12 adult cases of SBP in cirrhotic patients with P multocida. Nine patients were exposed to animals, though a break in the skin or a bite was not reported in each case. The SBP was fatal in four of these patients.

Virulence gene profiles of Pasteurella multocida strains isolated from cattle and buffalo

“…the nanB gene was detected in all samples in other studies (eWerS et al, 2006;FUrIaN et al, 2013), but was observed in 81.5% and 83.3% strains of P. multocida from clinical respiratory disease in pigs, and pneumonic and apparently healthy slaughter cattle, tested by taNG et al (2009) and khaMeSIPOUr et al (2014), respectively. the frequency of nanH was similar to that cited by khaMeSIPOUr et al (2014), but it differs from eWerS et al (2006), taNG et al (2009), FerreIra et al (2012 and FUrIaN et al (2013) who detected this gene in 88.5%, 97%, 67.3% and 96% of samples, respectively.…”

“…ompH and oma87 genes were identified in all samples in other studies (DaVIeS et al, 2004;eWerS et al, 2006;Bethe et al, 2009;FUrIaN et al, 2013) and were the most frequently detected genes in isolates in D. Gharibi et al: Virulence gene profile of Pasteurella multocida from cattle and buffalo other studies (taNG et al, 2009;FerreIra et al, 2012;khaMeSIPOUr et al, 2014). Omph is a major outer membrane porin that forms a homotrimeric channel, and has shown some potential as a protective antigen (CheVaLIer et al, 1993).…”

“…Similarly, ShaYeGh et al (2008) reported a low percentage of pfhA in clinically healthy and diseased sheep, and observed a correlation between the presence of the gene and disease in ovines. additionally, taNG et al (2009) and FUrIaN et al (2013) detected 15% and 60% of phfa in associated strains of P. multocida isolated from swine with clinical respiratory disease, and fowl cholera, respectively. the sialidases are enzymes that remove sialic acid conjugated to glycolipids and glycoproteins of eukaryotic cells (hatFa LUDI et al, 2010).…”

“…there are only a few studies that have determined the frequency of VFs correlated with pathogenic mechanisms (eWerS et al, 2006;Bethe et al, 2009;taNG et al, 2009;FerreIra et al, 2012;FUrIaN et al, 2013;khaMeSIPOUr et al, 2014). VFs play a key D. Gharibi et al: Virulence gene profile of Pasteurella multocida from cattle and buffalo role in disease production by bacterial pathogens, and their major functions include competence, adherence, synthesis and export of capsules, and evasion of host immune responses (NaNDUrI et al, 2009).…”

“…therefore, the related genes involved in this step are frequent targets for analysis of virulence ge notypes in P. multocida (hatFaLUDI et al, 2010). Studies by eWerS et al (2006), using various clinically healthy and diseased hosts, and taNG et al (2009) from clinical respiratory disease in pigs, have demonstrated that among the adhesins identified in samples of P. multo cida, including pfhA, tad, ptfA, fimA, and hsf-1,2, only fimA and hsf-1,2 were present in all pathogenic strains. the ptfA gene, which encodes a subunit of type IV fimbriae, was described in 81.8% of the isolates tested in the current study, a result similar to that observed in other studies (taNG et al, 2009;FerreIra et al, 2012;FUrIaN et al, 2013;khaMeSIPOUr et al, 2014).…”