Spontaneous arrhythmias in various models of cardiac hypertrophy and senescence of rats. A Holter monitoring study

Carré, François; Lessard, Yvon; Coumel, Philippe; Ollivier, Laurence; Besse, Sophie; Lecarpentier, Yves; Swynghedauw, Bernard

doi:10.1093/cvr/26.7.698

Cited by 37 publications

(17 citation statements)

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“…Despite the short period of ECG monitoring (30 min), this finding substantiates previous literature reports describing a higher incidence of this kind of arrhythmia, linked to aging, in rats submitted to 24-h Holter monitoring (20).…”

Section: Discussionsupporting

confidence: 90%

“…Ventricular arrhythmias was 30 times less frequent than in untreated old rats (Table 3). According to the classification of ventricular arrhythmia adopted in the present study (20), all young rats belonged to class 0, whereas 80% of the untreated old rats belonged to class 1, 2 or 3. As a result of treatment with captopril, the percentage of old rats in class 1 was 29%.…”

Section: Resultsmentioning

confidence: 71%

“…The total number of supraventricular (SVPB) and ventricular premature beats (VPB) were counted over the 30-min period. The classic definition of arrhythmias in humans, adapted to the high heart rate of the rat, has been described elsewhere (19,20) and was used to define the severity of ventricular arrhythmias. Briefly: class 0 -no VPB, class 1 -infrequent isolated unifocal VPB (<30/h), class 2 -frequent unifocal VPB (>30/h), class 3 -multifocal ectopic beats, class 4 -couplets of VPB, class 5 -triplets of VPB and non-sustained ventricular tachycardia (<6 ectopic beats), and class 6 -ventricular tachycardia.…”

Section: Methodsmentioning

confidence: 99%

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Chronic converting enzyme inhibition normalizes QT interval in aging rats

Silva

Neto

Salgado

et al. 2002

Braz J Med Biol Res

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The aim of the present study was to investigate the effects of converting enzyme inhibition by captopril on ECG parameters in aged rats. Four-month-old male rats received captopril dissolved in tap water (0.5 mg/l) or tap water for 2 or 20 months. At the end of treatment, under anesthesia, RR and PR interval, P wave and QRS duration, QT and corrected QT interval were measured in all animals. On the following day, chronic ECG (lead II) recordings were performed to quantify supraventricular (SVPB) or ventricular premature beats (VPB). After sacrifice, the hearts were removed and weighed. RR interval was similar in young and untreated aged rats, but significantly larger in aged rats treated with captopril. P wave and QRS length did not differ among groups. PR interval was significantly larger in old than in young rats and was not affected by captopril. Corrected QT interval was larger in aged than in young rats (117 ± 4 vs 64 ± 6 ms, P<0.05) and was reduced by captopril (71 ± 6 ms, P<0.05). VPB were absent in young rats and highly frequent in untreated old animals (8.4 ± 3.0/30 min). Captopril significantly reduced VPB in old rats (0.3 ± 0.1/30 min, P<0.05). The cardiac hypertrophy found in untreated aged rats was prevented by captopril (3.44 ± 0.14 vs 3.07 ± 0.10 mg/g, P<0.05). The beneficial effects of angiotensin converting enzyme inhibition on the rat heart during the aging process are remarkable.

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Section: Discussionsupporting

confidence: 90%

Section: Resultsmentioning

confidence: 71%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Chronic converting enzyme inhibition normalizes QT interval in aging rats

Silva

Neto

Salgado

et al. 2002

Braz J Med Biol Res

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show abstract

“…17 Assuming In fact, with aging, a decrease in the coronary blood flow, a loss of myocytes, and hypertrophy of the remaining cells accompanied by an increase in the interstitial collagen content associated with myocardial fibrosis have been reported.1-3'7 Since the collagen concentration is a major determinant for both diastolic compliance and arrhythmias, the increase in collagen concentration observed in the senescent myocardium could explain the elevation in LV stiffness and the high incidence of arrhythmias observed in senescent rats. 5 Indirect evidence for the cardiac and vascular effects of Ang II has been suggested by chronic treatment with ACE inhibitors (ACEI). ACEI have been reported to reduce LV hypertrophy in response to cardiac overload.48'49 ACEI given to old normotensive rats decreased arterial stiffening and LV mass.50 Such a treatment prevents cardiac fibrosis and arrhythmias in old hypertensive rats.…”

Section: Discussionmentioning

confidence: 99%

Activation of angiotensinogen and angiotensin-converting enzyme gene expression in the left ventricle of senescent rats.

1994

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BACKGROUND During senescence, the plasma angiotensin II concentration is decreased, but the regulation of intracardiac angiotensin II synthesis has never been investigated. The purpose of this work was to determine the cardiac content of both angiotensinogen (ANG) and angiotensin-converting enzyme (ACE) mRNAs in 24-month-old Wistar rats. METHODS AND RESULTS Total cardiac RNAs and known amounts of ANG and ACE mRNA transcripts, used as standards, were hybridized on slot blots with specific cDNA probes. The quantities of ANG and ACE mRNA were evaluated from the regression lines obtained with fragments of ANG and ACE mRNA in vitro transcripts. With aging, while the overall plasma renin-angiotensin system (RAS) activity decreased, in the left ventricle (LV) the amounts of ANG and ACE mRNAs were increased by fivefold (P < .01) and 2.5-fold (P < .01), respectively, compared with young adult controls. By contrast, in the right ventricle (RV) the same mRNA levels remained unchanged. In parallel, we also found an enhanced expression of the atrial natriuretic factor (ANF) in the LV but not in the RV. CONCLUSIONS During senescence, the depressed circulating RAS activity is in contrast to the increase of both ANG and ACE mRNA levels in the LV. Such an upregulation in both gene activities is more likely to be related to the age-associated changes in arterial compliance rather than to hormonal changes, since (1) this regulation is found only in the LV and (2) the same pattern of regulation is also observed for the ANF mRNA level.

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“…The number of arrhythmic events was scored during baseline and test recordings (Carré et al 1992;Sgoifo et al 1997).…”

Section: Telemetry System and Data Acquisitionmentioning

confidence: 99%

Effects of social stress on heart rate and heart rate variability in growing pigs

Jong¹,

Sgoifo²,

Lambooij³

et al. 2000

Can. J. Anim. Sci.

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. 2000. Effects of social stress on heart rate and heart rate variability in growing pigs. Can. J. Anim. Sci. 80: 273-280. The effects of social stress on heart rate, heart rate variability and the occurrence of cardiac arrhythmias were studied in 12 growing pigs. Social stress was induced during a good competition test with a pen mate, and subsequently during a resident-intruder test with an unacquainted pig in which the experimental pig was the intruder. The outcome of a test was determined using observations of agonistic behaviour. Five pigs won the food competition test. All pigs were defeated in the resident-intruder test with an unacquainted pig. For all pigs, heart rate was significantly higher and thus the R-R interval significantly lower during the food competition test and resident-intruder test than during baseline recordings. However, pigs that were first defeated in the food competition test had a higher heart rate during the first 7 min of the resident-intruder test than winners of the food competition test. Parameters of heart rate variabiality did not significantly change during the food competition test and the resident-intruder test relative to baseline recordings. Thus, the parasympathetic and the sympathetic nervous system remained in balance during the social stress situations. This may explain why the occurrence of cardiac arrhythmias did not increase during the food competition test and the resident-intruder test relative to baseline. We showed that social status, based on agonistic encounters during the food competition test, may influence the heart rate responses of pigs during the resident-intruder test. When heart rate is used as an index of stress, results indicate that subordinate pigs may experience more stress during an agonistic encounter with an unacquainted pig than dominant pigs.Key words: Behaviour, heart rate, social stress, telemetry, pigs de Jong, I. C., Sgoifo, A., Lambooij, E., Korte, S. M., Blokhuis, H. J. et Koolhaas, J. M. 2000. Effets de stress sociaux sur le rythme cardiaque et sur sa variabilité chez des porcs en croissance. Can. J. Anim. Sci. 80: 273-280. Nous avons étudié sur 12 porcs en croissance les effets de stress sociaux sur le rythme cardiaque et sa variabilité ainsi que sur la fréquence des cas d'arythmie cardiaque. Le stress social en question était provoqué durant un test de concurrence pour la nourriture avec un compagnon de case habituel et ensuite durant un test de confrontation entre compagnons de case et un porc étranger, test dans lequel l'animal expérimental était l'intrus. L'issue du test était déterminée d'après observation des comportements agonistes. Cinq porcs emportaient la lutte dans le test de concurrence pour la nourriture et tous les porcs logés en groupe étaient battus dans le test de confrontation avec le porc étranger. Chez tous les porcs, le rythme cardiaque était significativement plus élevé et par conséquent, l'intervalle RR était significativement plus court dans les deux tests de concurrence et de confrontation que durant les enr...

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Spontaneous arrhythmias in various models of cardiac hypertrophy and senescence of rats. A Holter monitoring study

Cited by 37 publications

References 0 publications

Chronic converting enzyme inhibition normalizes QT interval in aging rats

Chronic converting enzyme inhibition normalizes QT interval in aging rats

Activation of angiotensinogen and angiotensin-converting enzyme gene expression in the left ventricle of senescent rats.

Effects of social stress on heart rate and heart rate variability in growing pigs

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