Spontaneous and stimulated secretion of QUSO-extractable immunoassayable ACTH in man

Voigt, Kai‐Ingo; Fehm, Horst L.; R, Reck; Pfeiffer, E. F.

doi:10.1007/bf01468721

Cited by 39 publications

(17 citation statements)

References 18 publications

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“…7, the effects of dexamethasone (1 mg/15 min) on ACTH levels are demonstrated. There were no definite effects on ACTH levels during the first 15 min. An almost identical time course of ACTH levels was observed with infusion of 1.25 mg dexamethasone/h at a constant rate (data not shown).…”

Section: Resultsmentioning

confidence: 70%

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Differential and Integral Corticosteroid Feedback Effects on ACTH Secretion in Hypoadrenocorticism

Fehm¹,

Voigt²,

Kummer³

et al. 1979

J. Clin. Invest.

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A B S T R A C T Recent work suggests the existence of a dual corticosteroid feedback mechanism of stressinduced ACTH secretion in the rat. This possibility led us to study the kinetics of suppression of ACTH levels by corticosteroid administration in patients with nonstress ACTH hypersecretion secondary to hypoadrenocorticism. Cortisol was administered according to different protocols, which were chosen to provide extreme variations of the input signal. By this means, two phases of suppression ofACTH levels could be differentiated. A first decrease occurred without latency whenever, and as long as, plasma cortisol levels were rising. There was a linear regression between the logarithm of the increments in cortisol concentrations and the decrease in ACTH levels per minute (r = 0.951) (differential or rate-sensitive feedback mechanism). Neither the absolute doses of cortisol, nor plasma cortisol concentrations were closely correlated with the degree of suppression of ACTH by this rapid mechanism. A second decrease in ACTH levels began _30 min after corticosteroid administration. In this case there was a significant linear regression between the degree of inhibition of ACTH levels and the cortisol doses (r = 0.997) (integral or dose-sensitive feedback mechanism).The dose-sensitive feedback effects ofdexamethasone were less than might have been predicted from its relative anti-inflammatory potency. No rate-sensitive effects were seen with dexamethasone doses of 1.0 or 1.25 mg.

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Section: Resultsmentioning

confidence: 70%

“…Plasma-ACTH was estimated by radioimmunoassay after extraction of ACTH from the plasma as previously described (14,15). Starting ACTH levels in all patients 24 h after the last ingestion of corticosteroids were markedly elevated (1,450.5±334.3 pg/ml; mean±SEM; normal range 0-150 pg/ ml).…”

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confidence: 99%

Differential and Integral Corticosteroid Feedback Effects on ACTH Secretion in Hypoadrenocorticism

Fehm¹,

Voigt²,

Kummer³

et al. 1979

J. Clin. Invest.

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“…Plasma ACTH was estimated by radioimmunoassay after extraction of ACTH from the plasma as previously described (12,13 (15). As only this segment of the curves was important for testing the hypothesis, we did not attempt to describe the whole curves by statistical analysis.…”

Section: Introductionmentioning

confidence: 99%

Positive Rate-Sensitive Corticosteroid Feedback Mechanism of ACTH Secretion in Cushing's Disease

Fehm¹,

Voigt²,

Kummer³

et al. 1979

J. Clin. Invest.

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A B S T R A C T To define the nature of the disturbance of the corticosteroid feedback mechanism in Cushing's disease, the dynamic aspects of the ACTH response to corticosteroid administration have been studied in patients with Cushing's disease after total adrenalectomy (C.d. post adx. From these results it is concluded that in the patients with C.d. post adx. the rapid, rate-sensitive feedback mechanism was converted into a positive one, whereasPortions of these data have been reported at The 23rd Symposium

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“…Serum cortisol and ll-deoxycortisol were measured by radioimmunoassay using commercially available reagents (NEN, Dreieich, DRG Instruments, Marburg, FRG), plasma ACTH was determined by radioimmunoassay [1] after extraction with QUSO G 32 [18].…”

Section: Protocolmentioning

confidence: 99%

Nonhypnotic low-dose etomidate for rapid correction of hypercortisolaemia in cushing's syndrome

Allolio¹,

Schulte²,

Kaulen³

et al. 1988

Klin Wochenschr

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Spontaneous and stimulated secretion of QUSO-extractable immunoassayable ACTH in man

Cited by 39 publications

References 18 publications

Differential and Integral Corticosteroid Feedback Effects on ACTH Secretion in Hypoadrenocorticism

Differential and Integral Corticosteroid Feedback Effects on ACTH Secretion in Hypoadrenocorticism

Positive Rate-Sensitive Corticosteroid Feedback Mechanism of ACTH Secretion in Cushing's Disease

Nonhypnotic low-dose etomidate for rapid correction of hypercortisolaemia in cushing's syndrome

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