Spontaneous and Experimental Hepatitis A in Old World Monkeys

Shevtsova, Z V; Лапин, Б. А.; Doroshenko, N. V.; Krilova, R I; Korzaja, L I; Lomovskaya, I. B.; Dzhelieva, Z. N.; Zairov, G K; Stakhanova, V. M.; Belova, E G

doi:10.1111/j.1600-0684.1988.tb00380.x

Cited by 30 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cite this article as Cold Spring Harb Perspect Med 2019;9:a033456 classified in a distinct genotype (Nainan et al 1991; see Smith and Simmonds 2018). Cynomolgus macaques are also susceptible to infection with human HAV (Shevtsova et al 1988;Amado et al 2010), and the histopathology of the liver following intravenous inoculation with a human HAV isolate (HAF-203) has been described (Amado et al 2010). Initially, swelling of hepatocytes and microvesicular steatosis were evident by day 7 postinoculation.…”

Section: Comparative Pathology Of Hav and Hev Infectionsmentioning

confidence: 99%

Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection

Cullen

Lemon

2018

Cold Spring Harb Perspect Med

View full text Add to dashboard Cite

Hepatitis A virus (HAV) and hepatitis E virus (HEV) cause acute, self-limiting hepatic infections that are usually spread by the fecal-oral route in humans. Naturally occurring and experimental infections are possible in a variety of nonhuman primates and, in the case of HEV, a number of other species. Many advances in understanding the pathogenesis of these viruses have come from studies in experimental animals. In general, animals infected with these viruses recapitulate the histologic lesions seen in infected humans, but typically with less severe clinical and histopathological manifestations. This review describes the histopathologic changes associated with HAV and HEV infection in humans and experimental animals.

show abstract

Section: Comparative Pathology Of Hav and Hev Infectionsmentioning

confidence: 99%

Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection

Cullen

Lemon

2018

Cold Spring Harb Perspect Med

View full text Add to dashboard Cite

show abstract

“…It is well accepted that chimpanzees, tamarins, cynomolgus macaques, and owl monkeys are susceptible to HAV. Serologic evidence exists for the infection of rhesus macaques, stump-tailed macaques, Celebes black macaques, baboons, African green monkeys, capuchins (Cebus albifrons), marmosets, spider monkeys (Ateles geoffroyi), gibbons (Hylobates lar), mandrills, and patas monkeys with the same or similar viruses (Eichberg and Kalter, 1980;Anonymous, 1981;Brack, 1987a;Lankas and Jensen, 1987;Shevstsova et al, 1988;Potkay, 1992).…”

Section: Introductionmentioning

confidence: 99%

Viral Diseases of Nonhuman Primates

Wachtman

Mansfield

2012

Nonhuman Primates in Biomedical Research

103

View full text Add to dashboard Cite

“…However, several NHPs tested positive for HAV and a few clinical signs of HAV-infected NHPs were reported. The literature has documented the outbreak of spontaneous hepatitis A in imported rhesus monkeys showing clinical signs similar to those in humans [ 61 ]. To the best of our knowledge, there is no previous research on HAV infection in golden snub-nosed monkeys.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Survey and Risk Factor Analysis of 14 Potential Pathogens in Golden Snub-Nosed Monkeys at Shennongjia National Nature Reserve, China

Wang

et al. 2023

Pathogens

View full text Add to dashboard Cite

Golden snub-nosed monkeys (Rhinopithecus roxellanae) belong to Class A, the highest level of endangered primate species. Exploring the infection status of potential pathogens in golden snub-nosed monkeys is important for controlling associated diseases and protecting this species. The objective of this study was to investigate the seroprevalence for a number of potential pathogens and the prevalence of fecal adenovirus and rotavirus. A total of 283 fecal samples were collected from 100 golden snub-nosed monkeys in December 2014, June 2015, and January 2016; 26 blood samples were collected from 26 monkeys in June 2014, June 2015, January 2016 and November 2016 at Shennongjia National Reserve in Hubei, China. The infection of 11 potential viral diseases was examined serologically using an Indirect Enzyme-linked Immunosorbent Assay (iELISA) and Dot Immunobinding Assays (DIA), while the whole blood IFN-γ in vitro release assay was used to test tuberculosis (TB). In addition, fecal Adenovirus and Rotavirus were detected using Polymerase Chain Reaction (PCR). As a result, the Macacine herpesvirus-1 (MaHV-1), Golden snub-nosed monkey cytomegalovirus (GsmCMV), Simian foamy virus (SFV) and Hepatitis A virus (HAV) were detected with the seroprevalence of 57.7% (95% CI: 36.9, 76.6), 38.5% (95% CI: 20.2, 59.4), 26.9% (95% CI: 11.6, 47.8), and 7.7% (95% CI: 0.0, 84.2), respectively. Two fecal samples tested positive for Adenovirus (ADV) by PCR, with a prevalence of 0.7% (95% CI: 0.2, 2.5), and further, the amplification products were sequenced. Phylogenetic analysis revealed that they belonged to the HADV-G group. However, other pathogens, such as Coxsackievirus (CV), Measles virus (MeV), Rotavirus (RV), Simian immunodeficiency virus (SIV), Simian type D retroviruses (SRV), Simian-T-cell lymphotropic virus type 1 (STLV-1), Simian varicella virus (SVV), Simian virus 40 (SV40) and Mycobacterium tuberculosis complex (TB) were negative in all samples. In addition, a risk factor analysis indicated that the seroprevalence of MaHV-1 infection was significantly associated with old age (≥4 years). These results have important implications for understanding the health status and conservation of the endangered golden snub-nosed monkey population at Shennongjia Nature Reserve.

show abstract

Spontaneous and Experimental Hepatitis A in Old World Monkeys

Cited by 30 publications

References 8 publications

Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection

Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection

Viral Diseases of Nonhuman Primates

Epidemiological Survey and Risk Factor Analysis of 14 Potential Pathogens in Golden Snub-Nosed Monkeys at Shennongjia National Nature Reserve, China

Contact Info

Product

Resources

About