Spontaneous and ConA-Induced Suppressor Lymphocytes: A Comparative Study

Effect of orally administered bovine colostrum on cytokine production in vivo and in vitro in immunosuppressed mice

“…In addition, we assumed that it was highly plausible that after depletion of T cells by cyclophosphamide (Rollinghoff, Starzinski-Powitz, Pfizenmaier, & Wagner, 1977), bovine colostrum may affect reconstitution of T cell pool indirectly, by inducing relevant cytokines from cells of the reticuloendothelial system in the bone marrow and spleen. Therefore, we not only assayed the cytokine levels in vivo, but we also detected the cytokine levels in splenocyte culture supernatants induced by ConA, since T lymphocytes in a resting or non-activated stage usually show minimal or undetectable cytokine expression, which makes systematic investigation of basal cytokine profiles a difficult task (Gattringer, Huber, Michlmayr, & Braunsteiner, 1981).…”

abl oncogene expression in non‐Hodgkin lymphomas: Correlation to histological differentiation and clinical status

“…(3) Double itnmunofuorescence staining. B and T cells of peripheral blood and tonsils were separated using a sheep red blood cell assay for rosetting (Gattringer et al, 1981). E-and E…”

Concanavalin A induced suppressor cell activity and autorosette forming cells in chronic myeloid leukemia patients

“…However, a signifiantly higher degree of spontaneous suppression was seen in lymphocytes from CML patients than from healthy donors. Spontaneous generation of suppressor cells has been shown to occur by other investigators (Burns et al, 1975;Gattringer et al, 1981;Tsokos & Balow, 1982). It was surprising to note that in our experiments patients in the 3rd remission, who are closer to the terminal stage of the disease, showed spontaneous suppression comparable to normal donors.…”