Spontaneous alternation in rats with lesions in the frontal lobes: An extension of the frontal lobe syndrome

Divac, Ivan; Wikmark, R. G. E.; Gade, Anders

doi:10.3758/bf03326820

Cited by 89 publications

(42 citation statements)

References 22 publications

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“…The SAAT has been used before as a test of spatial working memory in rats and lesions of the prefrontal cortex impair performance on this task [41][42][43][44][45][46]. Our results showed an improvement in test performance in animals exposed to stress for seven days.…”

Section: Discussionmentioning

confidence: 50%

“…The spontaneous arm alternation test (SAAT) is used to measure spatial working memory in laboratory animals [41][42][43][44][45][46]. The SAAT was performed in a wooden maze with four closed arms (0.47 × 0.16 × 0.34 m) and an open central space (0.16 × 0.16 m) located 0.5 m away from the floor.…”

Section: Behavioral Testsmentioning

confidence: 99%

“…More specifically, we address the effects of chronic stress both on the spatial-temporal distribution of PNN + neurons in the PFC and on tests of executive function during adolescence. To test maladaptive executive function associated with deficits in working memory and bad judgment in decision making we used the spontaneous alternation [41][42][43][44][45][46] and the open field test [47], respectively.…”

Section: Introductionmentioning

confidence: 99%

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Effect of chronic stress during adolescence in prefrontal cortex structure and function

Folha

Bahia

Aguiar

et al. 2017

Behavioural Brain Research

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h i g h l i g h t s• Chronic stress impairs the development of the adolescent brain.• Chronic stress delays the maturation of extracellular structures called perineuronal nets, which stabilize synaptic contacts on inhibitory neurons, and prefrontal cortex-associated behavior.• These negative effects of chronic stress on the prefrontal cortex can theoretically occur in humans. Critical periods of plasticity (CPPs) are defined by developmental intervals wherein neuronal circuits are most susceptible to environmental influences. The CPP of the prefrontal cortex (PFC), which controls executive functions, extends up to early adulthood and, like other cortical areas, reflects the maturation of perineuronal nets (PNNs) surrounding the cell bodies of specialized inhibitory interneurons. The aim of the present work was to evaluate the effect of chronic stress on both structure and function of the adolescent's rat PFC. We subjected P28 rats to stressful situations for 7, 15 and 35 days and evaluated the spatial distribution of histochemically-labeled PNNs in both the Medial Prefrontal Cortex (MPFC) and the Orbitofrontal Cortex (OFC) and PFC-associated behavior as well. Chronic stress affects PFC development, slowing PNN maturation in both the (MPFC) and (OFC) while negatively affecting functions associated with these areas. We speculate upon the risks of prolonged exposure to stressful environments in human adolescents and the possibility of stunted development of executive functions.

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Section: Discussionmentioning

confidence: 50%

Section: Behavioral Testsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of chronic stress during adolescence in prefrontal cortex structure and function

Folha

Bahia

Aguiar

et al. 2017

Behavioural Brain Research

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“…Damage to the DMT causes rats to spontaneously alternate at chance level (Means et aI., 1974). Furthermore, lesions of the anteromedial frontal cortex in the rat interfere with the performance of spontaneous alternation (Divac, Wikmark, & Gade, 1975).…”

Section: Experiments 2 Spontaneous Alternationmentioning

confidence: 99%

A comparison of the effects of medial frontal, dorsomedial thalamic, and combination lesions on discrimination and spontaneous alternation in the rat

Weis

Means

1980

Psychobiology

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“…Yadin et al 1991;Ulloa et al 2004) that are characterized by perseverative deficits in inhibitory control (Joel et al 2008). SAB is also sensitive to the effects of lesions in corticostriatal circuitry (Divac et al 1975;Delatour & Gisquet-Verrier 1996) and to the administration of drugs (e.g. Quinpirole) that are standard pharmacological models of OCD in rodents (Joel et al 2008).…”

Section: Form Of Stereotypic Behaviour Definitionmentioning

confidence: 99%

Correlates of birth origin effects on the development of stereotypic behaviour in striped mice, Rhabdomys

2011

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The behaviour and physiology of wild animals born in zoos, laboratories and breeding centres can differ substantially from that of their wild-caught (WC) conspecifics. For instance, captive-born (CB) animals are typically more prone to developing abnormal repetitive behaviours. In captive striped mice, Rhabdomys, we first confirmed that birth origin predicted the emergence of stereotypic behaviour (SB), with CB mice being most at risk. Second, to investigate correlates of this birth origin effect, we tested WC and CB striped mice in behavioural tasks to quantify fear/anxiety, activity and perseveration, and measured faecal corticosterone to assess physiological stress. WC mice proved more fearful and less active than CB animals, and had higher levels of faecal corticosterone metabolites. These effects, however, were unrelated to SB. WC mice were also less perseverative and more behaviourally flexible than CB animals, traits that covary with SB. Third, a retrospective analysis of laboratory records showed that SB incidence was significantly lower in adult-caught than juvenile-caught striped mice, with juvenile males being the most severely affected by early removal from the wild. In conclusion, our results indicate that adult, but not juvenile WC striped mice are typically protected against SB development in captivity, despite having poorer welfare than their CB conspecifics. They also reveal profound behavioural changes in CB mice, changes suggestive of altered forebrain function, a hypothesis now needing direct testing. Ó

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Spontaneous alternation in rats with lesions in the frontal lobes: An extension of the frontal lobe syndrome

Cited by 89 publications

References 22 publications

Effect of chronic stress during adolescence in prefrontal cortex structure and function

Effect of chronic stress during adolescence in prefrontal cortex structure and function

A comparison of the effects of medial frontal, dorsomedial thalamic, and combination lesions on discrimination and spontaneous alternation in the rat

Correlates of birth origin effects on the development of stereotypic behaviour in striped mice, Rhabdomys

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