Spontaneous activity of foregut and hindgut visceral muscle of the locust, Locusta migratoria—II. The effect of biogenic amines

Huddart, H.; Oldfield, Anthony C.

doi:10.1016/0306-4492(82)90126-5

Cited by 34 publications

(21 citation statements)

References 16 publications

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“…Exogenously applied tyramine also alters the behavior of bees, increasing their responsiveness to sucrose (Scheiner et al, 2002). Some of these effects, however, may reflect peripheral rather than central actions of tyramine, as tyramine has modulatory actions on many peripheral tissues (e.g., Downer, 1979;Huddart and Oldfield, 1982;Nagaya et al, 2002;Blumenthal, 2003;Donini and Lange, 2004).…”

Section: Discussionmentioning

confidence: 97%

Developmental expression of a tyramine receptor gene in the brain of the honey bee, Apis mellifera

Mustard

Kurshan

Hamilton

et al. 2005

J of Comparative Neurology

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This study reveals that the tyramine receptor gene, Amtyr1, is expressed in the developing brain, as well as in the brain of the adult worker honey bee. Changes in levels of Amtyr1 expression were examined using Northern analysis. Age-related increases in Amtyr1 transcript levels were observed not only during metamorphic adult development, but also in the brain of the adult worker bee. RNA in situ hybridization revealed the pattern of Amtyr1 expression. Cell bodies staining intensely for tyramine receptor-gene transcript were observed throughout the somata rind, with well-defined clusters of cells associated with developing mushroom bodies, optic lobes, and antennal lobes of the brain. Staining for Amtyr1 transcript was particularly intense within the three major divisions of mushroom body intrinsic neurons (outer compact, noncompact, and inner compact cells), suggesting that Amtyr1 is highly expressed in these structures. Activation of AmTYR1 receptors heterologously expressed in insect (Spodoptera frugiperda) cells led to a reduction in intracellular levels of cAMP similar to that reported for AmTYR1 receptors expressed in mammalian (HEK 293) cells (Blenau et al. [2000] J Neurochem 74:900-908). Taken together, these results suggest that AmTYR1 receptors may play a role in the developing brain as well as in the brain of the adult worker bee. The actions of tyramine are likely to be mediated, at least in part, via the cAMP-signaling pathway.

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Section: Discussionmentioning

confidence: 97%

Developmental expression of a tyramine receptor gene in the brain of the honey bee, Apis mellifera

Mustard

Kurshan

Hamilton

et al. 2005

J of Comparative Neurology

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“…Synthesized via the decarboxylation of tyrosine, TA has long been known to be a precursor for the synthesis of octopamine (OA); however, the past decade has seen growing evidence that TA has physiological roles independent of OA (Lange, 2009;Roeder, 2005). These include effects on olfactory behavior (Kutsukake et al, 2000), locomotion and flight (Brembs et al, 2007;Saraswati et al, 2004;Vierk et al, 2009), neuromuscular transmission (Kutsukake et al, 2000;Nagaya et al, 2002), sleep (Crocker and Sehgal, 2008), appetite (Nisimura et al, 2005), behavioral responses to cocaine and ethanol (Hardie et al, 2007;McClung and Hirsh, 1999;Scholz, 2005) and muscular contractions (da Silva and Lange, 2008;Donini and Lange, 2004;Huddart and Oldfield, 1982). Receptors have been cloned from Drosophila and other insect species that are either specific for TA and not OA (Cazzamali et al, 2005) or preferentially activated by TA over OA (Arakawa et al, 1990;Blenau et al, 2000;Molaei et al, 2005;Ohta et al, 2003;Saudou et al, 1990;Vanden Broeck et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Isoform- and cell-specific function of tyrosine decarboxylase in theDrosophilaMalpighian tubule

Blumenthal

2009

Journal of Experimental Biology

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SUMMARYThe biogenic amine tyramine (TA) is a potent diuretic factor when applied to the Malpighian tubule (MT) of Drosophila melanogaster, stimulating both urine production and transepithelial chloride conductance. Isolated MTs can respond not only to TA but also to its precursor, tyrosine; this observation led to the proposal that MTs are able to synthesize TA from applied tyrosine through the action of the enzyme tyrosine decarboxylase (TDC). In the current study it is shown that the non-neuronal isoform of TDC, Tdc1, is expressed in the principal cells of the MT. A mutant allele of Tdc1, Tdc1 f03311 , was identified that reduced expression of the mature Tdc1 transcript by greater than 100-fold. MTs isolated from Tdc1 f03311 homozygous flies showed no significant depolarization of their transepithelial potential (TEP) or diuresis in response to tyrosine while retaining normal sensitivity to TA. By contrast, a previously identified null mutant allele of the neuronal TDC isoform Tdc2 had no effect on either tyrosine or TA sensitivity. To determine in which cell type of the MT Tdc1 expression is required, flies were generated carrying a UAS-Tdc1 transgene and cell-type-specific Gal4 drivers on a Tdc1 f03311 homozygous background. Rescue of Tdc1 expression in principal cells fully restored sensitivity to tyrosine whereas expression of Tdc1 in stellate cells had no rescuing effect. It is concluded that synthesis of TA by Tdc1 in the principal cells of the MT is required for physiological responses to tyrosine. TA synthesis in the MT is the first reported physiological role for Drosophila Tdc1.

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“…These peristaltic contractions are myogenic in nature, but can be modified by neural input. In the locust, foregut and hindgut myogenic contractions are modulated by input from the nervous system through the innervation from the stomatogastric nervous system (STNS) and last abdominal ganglion of the central nervous system (CNS), respectively (Albrecht, 1953;Donini et al, 2002;Möhl, 1972;Huddart and Oldfield, 1982). The frontal ganglion is involved in the control of movements of the anterior foregut or pharynx, and is the major source of innervations to the dilator muscles (Albrecht, 1953;Zilberstein and Ayali, 2002;Bräunig, 2008).…”

Section: Introductionmentioning

confidence: 99%

The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

Robertson

Rodriguez

Lange

2012

Journal of Experimental Biology

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Spontaneous activity of foregut and hindgut visceral muscle of the locust, Locusta migratoria—II. The effect of biogenic amines

Cited by 34 publications

References 16 publications

Developmental expression of a tyramine receptor gene in the brain of the honey bee, Apis mellifera

Developmental expression of a tyramine receptor gene in the brain of the honey bee, Apis mellifera

Isoform- and cell-specific function of tyrosine decarboxylase in theDrosophilaMalpighian tubule

The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

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