Spontaneous Activity Level and Life Span in Rotifers: Lack of Support for the Rate of Living Theory

Enesco, Hildegard E.; McTavish, Alison; Garberi, Riccardo

doi:10.1159/000213209

Cited by 16 publications

(7 citation statements)

References 20 publications

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“…Hydra, a primitive Cnidarian animal, in which no long-lived cells are found, has been shown to escape aging under favorable experimental conditions (49), whereas adult forms of rotifers, nematodes, and insects, which are largely composed of long-lived postmitotic cells, exhibit rapid senescence (1,29,32). Similarly, cultured malignant cells with unlimited proliferation potential do not show any senescence-like changes, while growth-arrested normal cells undergo progressive alterations with age in the same way as postmitotic cardiac myocytes do (21,76,77).…”

Section: Age-related 'Garbage' Accumulation Primarily Occurs In Long-mentioning

confidence: 99%

Oxidative Stress, Accumulation of Biological 'Garbage', and Aging

Terman

Brunk

2006

Antioxidants & Redox Signaling

320

215

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Normal metabolism is associated with unavoidable mild oxidative stress resulting in biomolecular damage that cannot be totally repaired or removed by cellular degradative systems, including lysosomes, proteasomes, and cytosolic and mitochondrial proteases. Consequently, irreversibly damaged and functionally defective structures (biological 'garbage') accumulate within long-lived postmitotic cells, such as cardiac myocytes and neurons, leading to progressive loss of adaptability and increased probability of death and characterizing a process called aging, or senescence. Intralysosomal 'garbage' is represented by lipofuscin (age pigment), an undegradable autophagocytosed material, while extralysosomal 'garbage' involves oxidatively modified cytosolic proteins, altered biomembranes, defective mitochondria and other organelles. In aged postmitotic cells, heavily lipofuscin-loaded lysosomes perform poorly, resulting in the enhanced accumulation of defective mitochondria, which in turn produce more reactive oxygen species causing additional damage (the mitochondrial-lysosomal axis theory). Potential anti-aging strategies may involve not only overall reduction of oxidative stress, but also the use of intralysosomal iron chelators hampering Fenton-type chemistry as well as the stimulation of cellular degradative systems.

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Section: Age-related 'Garbage' Accumulation Primarily Occurs In Long-mentioning

confidence: 99%

Oxidative Stress, Accumulation of Biological 'Garbage', and Aging

Terman

Brunk

2006

Antioxidants & Redox Signaling

320

215

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“…This view was based primarily on the rate of living theory first proposed by Pearl (1928), which states that longevity is inversely proportional to metabolic rate. However, this theory has not found much support in the literature whether in dealing with rotifers (Enesco et al 1990), nematodes , fruit flies (Van Voorhies et al 2003;Hulbert et al 2004;Khazaeli et al 2005), or rodents (Masoro et al 1982;McCarter and Palmer 1992;Speakman et al 2004). While the link between the metabolic rate and longevity still remains obscure and controversial, an inverse relationship between high rates of fecundity and longevity has been documented in many species (Rose and Charlesworth 1981;Ernsting and Isaaks 1991;Kaitala 1991;Braeckman et al 2002), and it was thoroughly examined in rotifers by Snell and King (1977).…”

Section: Introductionmentioning

confidence: 99%

The effect of temperature on life history parameters and cost of reproduction in the rotiferBrachionus calyciflorus

Kauler

Enesco

2011

Journal of Freshwater Ecology

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We used the monogonont rotifer, Brachionus calyciflorus, to study the effect of ambient temperatures of 16 C, 22 C, and 29 C on longevity and life history parameters. We found that temperature had a significant relationship with longevity. At lower temperature, there was prolongation of the pre-reproductive and reproductive periods, but fecundity was reduced significantly due to suppression of the reproductive rate. When lifespan of short-and long-lived rotifers was compared, we found that the significant longevity difference in these rotifers was due to extension of reproductive and post-reproductive periods. The fecundity was significantly higher in longer lived rotifers due to the extension of the reproductive period, but the reproductive rate was significantly lower in these rotifers. A consistent negative relationship between rotifer longevity and the rate of reproduction was observed at all temperatures, and it was particularly pronounced in rotifers reproducing heavily at the end of the reproductive stage of their life cycle. The combined rate of living/oxidative damage theory may help explain the temperature effects that we observed.

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“…Individuals 1 and 2 ( Fig . 3) seemed older than the others as their movements were slower and more sinuous (see Beauvais & Enesco, 1985 ;Enesco et al, 1990 ;Mimouni & Clement, unpublished data) . The mean of the four repetitions in each condition (WL, IR) was computed for the nine females for all indices to perform the Wilcoxon test .…”

Section: Resultsmentioning

confidence: 99%

How females of the rotifer Asplanchna brightwelli swim in darkness and light: an automated tracking study

1993

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This work explores the effect of darkness on the swimming behaviour of females of the rotifer Asplanchna brightwelli . Females were filmed in flat dishes alternately in white light (WL, 5000 µW cm -2) and in infra-red light (IR, 155 µW cm -2 ), each female for a total of eight successive periods of fifteen minutes per period . An automated tracking system was used to describe the swimming path of each female : twenty five x and y coordinates of the center of gravity of the animal per second, in a discrete space of 512 x 512 pixels . Indices characterizing the swimming performances of the females were then calculated : linear speed, angular speed and other angular parameters of the tracks . A Principal Component Analysis of swimming characteristics discriminated between WL tracks and IR tracks . Females swam slower and turned more in darkness than in light . These results show that beside a positive phototactic response, there is a photokinesis which increases the dispersion of animals in the light . 101

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Spontaneous Activity Level and Life Span in Rotifers: Lack of Support for the Rate of Living Theory

Cited by 16 publications

References 20 publications

Oxidative Stress, Accumulation of Biological 'Garbage', and Aging

Oxidative Stress, Accumulation of Biological 'Garbage', and Aging

The effect of temperature on life history parameters and cost of reproduction in the rotiferBrachionus calyciflorus

How females of the rotifer Asplanchna brightwelli swim in darkness and light: an automated tracking study

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