Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy

Kharbanda, Elyse O.; Haapala, Jacob; DeSilva, Malini B.; Vazquez‐Benitez, Gabriela; Vesco, Kimberly K.; Naleway, Allison L.; Lipkind, Heather S.

doi:10.1001/jama.2021.15494

Cited by 177 publications

(180 citation statements)

References 6 publications

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“… 85 Another study including 105,466 pregnancies showed that 8.0% of women with ongoing pregnancies had received a mRNA COVID-19 vaccine in the prior 28 days relative to an index date vs 8.6% of spontaneous abortions and the spontaneous abortions were not associated with an increased odds of COVID-19 vaccine exposure compared with ongoing pregnancies (adjusted odds ratio 1.02; 95% CI 0.96-1.08). 86 Emerging data continues to show that COVID-19 vaccination (including BNT162b2 and mRNA-1273) in pregnant women is safe, effective, and immunogenic, allowing transfer of antibodies to the neonates. 87 , 88 , 89 In August 2021 the CDC recommended COVID-19 vaccination for pregnant women.…”

Section: Clinical Data Of Mrna Therapeutics For Sars Cov-2mentioning

confidence: 99%

Messenger ribonucleic acid vaccines for severe acute respiratory syndrome coronavirus-2 – a review

Akamine

Sahly

2022

Translational Research

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The mRNA therapeutics have been studied since the 1970s and the currently available mRNA vaccines against COVID-19 are the culmination of decades of scientific research. The mRNA vaccines BNT162b2 and mRNA-1273 have played a key role in our global response to the COVID-19 pandemic as they have demonstrated significant advantages over conventional vaccines and have proven to be highly effective against COVID-19 associated hospitalization and severe illness in large clinical trials and studies using real-world data.

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Section: Clinical Data Of Mrna Therapeutics For Sars Cov-2mentioning

confidence: 99%

Messenger ribonucleic acid vaccines for severe acute respiratory syndrome coronavirus-2 – a review

Akamine

Sahly

2022

Translational Research

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“…Our study found no evidence of an increased risk for early pregnancy loss after Covid-19 vaccination and adds to the findings from other reports supporting Covid-19 vaccination during pregnancy. 3 , 4 …”

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confidence: 99%

Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage

et al. 2021

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“…approximately 172,000 to patients who were pregnant at the time of vaccination. Several studies have shown that the COVID-19 mRNA vaccine does not cause early pregnancy loss (before 20 weeks), 8,9 data on other potential effects of the vaccine in pregnancy remain limited but reassuring. 4 Three main tracking systems (CDC Covid-19 Vaccine Pregnancy Registry, Vaccine Safety Datalink (VSD) and Vaccine Adverse Reporting System (VERS)), have not identified increased maternal or fetal risk with COVID-19 vaccination.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Safety-Related Outcomes of Novel mRNA COVID-19 Vaccines in Pregnancy

et al. 2022

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Objective: To describe the safety profile and demographic data for a cohort of pregnant individuals who received an mRNA COVID-19 vaccine. Study Design: Prospective cohort study (with exposure matching) of individuals with active pregnancy who underwent immunization with a novel mRNA COVID-19 vaccine matched 1:2 with vaccinated age-matched female non-pregnant controls. Primary outcome was defined as any vaccine-related complaint as defined in the original safety data. Secondary outcomes included specific complaints, COVID-19 screening test and positive COVID-19 test. Results: Eighty-three vaccinated pregnant persons were age-matched with 166 female controls, all of whom were vaccinated between December 2020 and January 2021. There was no difference in race or ethnicity between the groups. The mean BMI of pregnant patients was lower than that of controls (26.1 vs 29.2, p=0.002). Frequency of complaint following vaccine administration was not different between pregnant and non-pregnant patients (18.1% vs 16.9%, P=0.201). Pregnant individuals were more likely to report fever (4.8% vs 0.6%, p=0.044) and gastrointestinal symptoms (4.8% vs 0%, p=0.012). Conclusions: Side effect profiles of Covid 19 vaccine administration at our institution were relatively similar between pregnant and non-pregnant individuals and no serious complications occurred in either group. As COVID-19 infection in pregnancy can have significant morbidity, our data support the continued use of the vaccine for pregnant patients.

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Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy

Abstract: Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Cited by 177 publications

References 6 publications

Messenger ribonucleic acid vaccines for severe acute respiratory syndrome coronavirus-2 – a review

Messenger ribonucleic acid vaccines for severe acute respiratory syndrome coronavirus-2 – a review

Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage

Safety-Related Outcomes of Novel mRNA COVID-19 Vaccines in Pregnancy

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