Spongiotic dermatitis with Langerhans cell microvesicles

Velez, Ana Maria Abreu; Howard, Michael S.; Brown, Vickie M.

doi:10.1111/cup.12595

Cited by 1 publication

(1 citation statement)

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“…[10][11][12] Notably, LCs seem to play a direct role in the intraepidermal vesiculation seen in spongiotic dermatitis. 13 In eradicating HPV skin infection, LCs act particularly through toll-like receptor (TLR)-3-induced production of interferon (IFN)-inducible chemokines, which augments the T-cell-mediated response. [14][15][16] Lack of LCs may hinder the cell-mediated inflammatory response to HPV infection, preventing wart regression.…”

Section: Discussionmentioning

confidence: 99%

Dermatologists' Impressions of Spontaneously Regressing Verruca Plana Histopathology

Choi

Park

Kim

2022

The American Journal of Dermatopathology

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:Verruca plana in its regressing phase exhibits clinical and histological features distinct from classic verruca plana, but the ways in which these features should inform treatment plans are still under investigation. We conducted a retrospective single-center analysis of 25 patients with features of classic verruca plana, or plane warts, who exhibited self-remission within 4 weeks of skin biopsy. Measures included lesion sites, clinical findings preceding regression, and histological analysis. Histological analysis involved review by 2 dermatologists followed by impressions given by 4 board-certified dermatologists who were blinded to the clinical characteristics of the patients. Histopathological findings of regressing plane warts showed superficial perivascular infiltration (96%), spongiosis and exocytosis (84%), basal vacuolization (64%), parakeratosis (64%), apoptotic keratinocytes (60%), and lichenoid infiltration (44%). These findings were more compatible with the histological patterns of pityriasis lichenoides, lichen planus, and spongiotic eczema, rather than classic verruca plana. This suggests that regressing verruca plana may be included in the differential diagnosis of lesions exhibiting a lichenoid or spongiotic reaction, and observation may be a favorable treatment plan in these patients.

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