Spondylodiskitis and endocarditis due to Streptococcus gordonii

Abstract

Background Streptococcus gordonii is an infrequent cause of infective endocarditis (IE); associated spondylodiskitis has not yet been described in the literature.PurposeWe describe 2 patients who presented with new-onset, severe back pain; blood cultures revealed S. gordonii bacteremia, which led to the diagnosis of spondylodiskitis and IE. We review our 2-decade experience with S. gordonii bacteremia to describe the clinical and epidemiological characteristics of these patients.ResultsIn our hospital over the last 20 years (1998–2017), a total of 15 patients with S. gordonii bacteremia were diagnosed, including 11 men and 4 women, and the mean age was 65 ± 22 (range 23–95). The most common diagnosis was IE (9 patients), spondylodiskitis (the presented 2 patients, who in addition were diagnosed with endocarditis), necrotizing fasciitis (1), sternitis (1), septic arthritis (1) and pneumonia (1). The 11 patients with IE were treated with penicillin ± gentamicin, or ceftriaxone for 6 weeks, 5 required valve surgery and 10/11 (91%) attained complete cure. The 2 patients with diskitis required 2–3 months of intravenous antibiotics to achieve complete cure.ConclusionSpondylodiskitis was the presenting symptom of 2/11 (18%) patients with S. gordonii endocarditis. Spondylodiskitis should probably be looked for in patients diagnosed with S. gordonii endocarditis and back pain as duration of antibiotic treatment to achieve complete cure may be considerably longer.

Differences in Gut Microbiota Profiles between Autoimmune Pancreatitis and Chronic Pancreatitis

“…Several bacterial species were more abundant in the gut microbiota of CP patients compared to those of AIP patients. Among them, Streptococcus australis and Streptococcus gordonii are generally present in the oral cavity, sometimes causing bacterial endocarditis (Warburton et al 2013;Dadon et al 2017). A greater abundance of Streptococcus has also been found in patients with intestinal diseases in a meta-analysis (Mancabelli et al 2017), suggesting a possible contribution of these bacterial species during the dysbiosis of CP patients.…”

Streptococcus gordonii: A Rare Cause of Infective Endocarditis

“…A link between IE and dental procedures has been identified and occurs via the breakdown of the mucocutaneous barriers. The viridans group of streptococci (VGS) are bacteria that have a low virulence and are usually present in the oral cavity, upper airways, gastrointestinal tract, and female genitalia [1]. The group is further classified into six major subgroups: S. mutans group, S. mitis group, S. anginosus group, S. salivarius group, S. bovis group, and S. sanguinis group [1, 2].…”

“…sanguinis , S . parasanguinis , and S. gordonii and rarely causes invasive infections including IE [1, 2]. The authors present a case of infective endocarditis caused by S. gordonii in an immunocompetent patient following a dental procedure.…”

Antimicrobial Activity of Exebacase (Lysin CF-301) against the Most Common Causes of Infective Endocarditis

“…Review of data from seven studies examining the causative agents of infective endocarditis in humans The viridans group streptococci causing IE include S. mitis, S. sanguinis, S. mutans, S. salivarius, S. gordonii, S. intermedius, and S. anginosus(28,(46)(47)(48).…”