Spondylodiscitis due to anaerobic bacteria about a case of Parvimonas micra infection

Pilmis, Benoît; Israel, J; Monnier, Alban Le; Mizrahi, Assaf

doi:10.1016/j.anaerobe.2015.05.013

Cited by 23 publications

(10 citation statements)

References 7 publications

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“…As the presenting symptoms in these patients were non-specific (e.g., fever, shake, and chills), thorough searches for the primary source of bacteremia may not have been carefully conducted in these 9 cases. In 27 literature cases, P. micra bacteremia were also frequently associated with oropharyngeal infection (7/27, 25.9%) and GIT infection (3/27, 11.1%) [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Other common infectious diseases of P. micra in the literature cases were spondylodiscitis (8/27, 29.6%), intra-abdominal abscess (4/27, 14.8%), IE (3.27, 11.1%), and septic pulmonary emboli (3/27, 11.1%) which is inconsistent with our results.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of bloodstream infection by Parvimonas micra: retrospective case series and literature review

et al. 2020

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Background: Gram-positive anaerobic (GPA) bacteria inhabit different parts of the human body as commensals but can also cause bacteremia. In this retrospective observational study, we analyzed GPA bacteremia pathogens before (2013-2015) and after (2016-2018) the introduction of the matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Method: We conducted a retrospective observational study by searching the microbiology database to identify all positive GPA blood cultures of patients with GPA bacteremia diagnosed using the new technique, MALDI-TOF MS,

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics of bloodstream infection by Parvimonas micra: retrospective case series and literature review

et al. 2020

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“…First-generation fluoroquinolones are inactive or marginally active against anaerobes,10 hence the course of ofloxacin was unlikely to have suppressed P. micra on her initial blood cultures. Owing to the widespread use of diagnostic technology such as matrix-assisted laser desorption ionisation-time of flight mass spectrometry and 16S rRNA sequencing,11 12 there has been an increasing number of P. micra being identified 8 13–17. Recently, Higashi et al described the melting temperature (Tm) mapping method which successfully detected P. micra in 3 hours, concluding it as a useful method in cases of bacterial infections where organisms are difficult to culture 8…”

Section: Discussionmentioning

confidence: 99%

Parvimonas micraspondylodiscitis with psoas abscess

2019

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Parvimonas micra (P. micra) is a Gram-positive anaerobic cocci, normally found in the oral cavity and rarely causes severe infections. We describe a rare clinical presentation of P. micra as spondylodiscitis and psoas abscess with haematogenous spread in an adult patient. MRI lumbar spine detected L2 and L3 spondylodiscitis. Blood cultures were positive at 48 hours of incubation and P. micra was identified on anaerobic culture after 72 hours. Isolates from bone biopsy confirms P. micra. She was successfully treated with ceftriaxone, followed by oral metronidzole for a total of 8 weeks. The suspected origin of her P. micra was a dental cavity. Anaerobic bacteria tend to be underestimated in spondylodiscitis. In cases of slow growing organisms, we emphasise the importance of performing accurate identification including anaerobic bacteria to guide management. P. micra should be considered in patients with spondylodiscitis who had recent dental intervention or perioral infection.

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“…Previous reports describe the difficulty to culture P. micra and due to this difficulty, it is possible that these bacteria are underreported as causative pathogen for bone and joint infections. 1,5 Direct 16S ribosomal RNA PCR-sequencing of bacterial DNA in joint fluid might be a viable diagnostic option in these cases.…”

Section: Discussionmentioning

confidence: 99%

“…Only two cases of septic arthritis with P. micra have been described before 1,4. Due to problems in culturing and identifying anaerobic strains, prevalence of P. micra may be underreported as a pathogen for bone and joint infections, as is mentioned in previous case reports 1,5,6. We used a 16S rRNA PCR-analysis for identifying P. micra .…”

Section: Introductionmentioning

confidence: 99%

Acute Mono-Arthritis of the Knee: A Case Report of Infection with Parvimonas Micra and Concomitant Pseudogout

Dietvorst

Roerdink

Leenders

et al. 2016

J. Bone Joint Infect.

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Parvimonas micra is a rare pathogen for septic arthritis and is known for its subacute onset. We report a case of acute arthritis of the knee caused by P. micra and pseudogout. Initially, calcium pyrophosphate crystals were found in the knee, which were successfully treated with a steroid injection. Only anaerobic cultures became positive. A 16S rRNA PCR-analysis was necessary to identify P. micra as causative agent, a method which is never described before in similar cases. The infection was treated with clindamycin for 6 weeks. This is the third case report of a septic arthritis caused by P. micra and the second which also reports concomitant pseudogout.

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Spondylodiscitis due to anaerobic bacteria about a case of Parvimonas micra infection

Cited by 23 publications

References 7 publications

Clinical characteristics of bloodstream infection by Parvimonas micra: retrospective case series and literature review

Clinical characteristics of bloodstream infection by Parvimonas micra: retrospective case series and literature review

Parvimonas micraspondylodiscitis with psoas abscess

Acute Mono-Arthritis of the Knee: A Case Report of Infection with Parvimonas Micra and Concomitant Pseudogout

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