Spondylodiscitis: A Retrospective Analysis of Clinical, Etiological, and Radiological Diagnosis

Abstract

Background: Spondylodiscitis is an uncommon disease, and due to its indolent nature, it is often a late diagnosis. Great stress is put on the etiologic diagnosis, but blood cultures do not always yield positive results. Magnetic resonance imaging (MRI), despite being the diagnostic method of choice, is not always available. Our aim was to characterize the clinical presentation and to identify and check the efficacy of the etiologic and radiological methods of diagnosis of spondylodiscitis used at our hospital.Methods: A retrospective study was conducted in which spontaneous spondylodiscitis cases were identified. The clinical presentation and the results of etiologic and radiological methods of diagnosis were analyzed.Results: Over a period of 5 years, 34 patients fulfilled the inclusion criteria of the study. Regarding days of complaints, we identified a median of 9.5 days (1-547 days), with back pain being the predominant symptom. Fever was present in half the patients. Blood cultures were positive in 16 patients (48.5%). Nineteen patients underwent a computed tomography (CT)-guided biopsy (positive in 7 patients [36.8%]), and 10 patients underwent a surgical biopsy (positive in half of them). Overall, 27 patients (79.4%) had an etiologic diagnosis. The diagnostic work-up consisted mostly of an initial CT scan followed by a confirmatory MRI. Of note, in 5 patients the CT scan did not reveal changes that were later confirmed by MRI. A total of 29 patients (85.3%) underwent an MRI, with 28 being diagnostic.Conclusions: Spondylodiscitis remain a difficult diagnosis. Blood cultures should always be obtained before antibiotic administration and a CT-guided or surgical biopsy should be done if needed. Our results confirm the importance of MRI as the imaging modality of choice and highlight the possibility of false-negative CT scans and the inability of CT to allow for a definitive diagnosis.

Early Imaging and Course-of-Disease Control Markers of Pyogenic Vertebral Osteomyelitis

“…Using MRI, an accurate diagnosis is established in 55% of cases with symptoms lasting less than two weeks, in 76% of cases -with symptoms lasting more than two weeks [23].…”

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“…Рекомендації щодо вибору оптимального хірургічного втручання суперечливі [2,6,17]. Основною метою хірургічного втручання є швидка декомпресія, агресивна санація та біопсія уражених тканин з подальшою стабілізацією хребцево-рухових сегментів [6].…”

“…Хірургічне лікування абсолютно показане при стисненні спинного мозку або нервових корінців з прогресуванням неврологічного дефіциту. Відносні хірургічні показання включають неефективність консервативного лікування, нестабільність, деформацію хребта через значну деструкцію кістки [2]. Враховуючи той факт, що більшість пацієнтів можна успішно лікувати консервативними засобами, хірургічне втручання переважно спрямоване на бактеріологічну або гістологічну верифікацію спондилодисциту, що досягається, в першу чергу, мініінвазивними перкутанними методиками [1].…”