Spondyloarthritis in North Africa: an update

Slimani, Samy; Hamdi, Wafa; Nassar, K.; Kalla, Asgar Ali

doi:10.1007/s10067-021-05630-w

Cited by 14 publications

(11 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both papers highlight the barriers faced by healthcare professionals in these regions, such as limited access to diagnostic tools, variations in disease presentation, and cultural influences on patient care. They stress the importance of early diagnosis and tailored management strategies to improve outcomes for patients with axSpA [ 2 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…In North Africa, SpA has received less attention compared to rheumatoid arthritis, partly due to the perception that it is rare and relatively benign in certain populations. Moreover, diagnosing SpA is often delayed [ 2 ]. The 2009 Assessment of Spondyloarthritis International Society (ASAS) classification criteria for axial spondyloarthritis (axSpA) as diagnostic criteria were devised to aid in identifying individuals likely to have axial SpA for research and clinical trial enrollment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Knowledge, Attitudes, and Practices of Moroccan Community Rheumatologists’ Regarding the Management of Non-radiographic Axial Spondyloarthritis: A National Cross-Sectional Study

Kronbi,

Rkain,

Benzine

et al. 2024

Cureus

View full text Add to dashboard Cite

IntroductionNon-radiographic axial spondyloarthritis (nr-axSpA) is within the spectrum of axial spondyloarthritis (axSpA). The emergence of the nr-axSpA concept, defined by the absence of significant erosive damage to the sacroiliac joints, has prompted numerous initiatives aimed at enhancing the early detection and management of this condition. The aim of the study was to assess the knowledge, attitudes, and practices related to the diagnosis and management of nr-axSpA by rheumatologists in Morocco. MethodsWe conducted a cross-sectional online survey among the rheumatologist community in Morocco. Rheumatologists received via e-mail a structured Google Forms (Google Inc., Mountainview, CA) questionnaire divided into four sections: sociodemographic data of rheumatologists, knowledge, attitudes, and practices related to the diagnosis and treatment management of nr-axSpA. ResultsA total of 110 rheumatologists (mean age of 44±13 years, 77.3% females, median professional experience of 12 years (4, 75; 26.25 years)) participated in the survey (response rate of 25%). Most responders reported a diagnosis delay issue in spondyloarthritis (SpA) (93.6%); 70.9% of rheumatologists incorrectly regarded the 2009 Assessment of Spondyloarthritis International Society (ASAS) classification criteria for axSpA as diagnostic criteria. Rheumatologists' awareness of recommended magnetic resonance imaging (MRI) sequences for detecting sacroiliac joint inflammation and structural changes in SpA varied significantly, from 69.1% to 14.5%. Their knowledge of additional subchondral edema cases in these joints, beyond SpA, ranged from 48.2% to 87.3%. Almost all rheumatologists believed that the use of sacroiliac MRI would contribute to the early diagnosis of axSpA (97.3%) but could also lead to false positive diagnoses, according to 47.3% of rheumatologists; 73.6% believed that incorrectly using the 2009 ASAS classification criteria as diagnostic criteria in nr-axSpA could also result in false-positive diagnoses. In their practice, 2009 ASAS classification criteria were used as diagnostic criteria in axSpA by 39.1% of rheumatologists. Of the total participants, 91.8% indicated that they approach nr-axSpA similarly to radiographic axial spondyloarthritis, with disparities in recommendations of biological therapies. ConclusionOur survey provides insight into the current status of nr-axSpA management among Moroccan rheumatologists. It also addresses concerns regarding the risk of false positive diagnoses when using the 2009 ASAS classification criteria for axSpA as diagnostic criteria by rheumatologists and the potential risk of misdiagnosis associated with excessive reliance on MRI, despite its utility for early diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitudes, and Practices of Moroccan Community Rheumatologists’ Regarding the Management of Non-radiographic Axial Spondyloarthritis: A National Cross-Sectional Study

Kronbi,

Rkain,

Benzine

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…However, only 52% of our AS case sample were HLA-B27 positive (Table 1). It has been found that the majority of studies in North African populations estimate the frequency of HLA-B27 between 50 and 60% among SA patients and between 3 and 4% among healthy individuals (Sakly et al, 2009, Atouf et al, 2012, Hamdi et al, 2012, Tayel et al, 2012, Slimani et al, 2021, Dahmani et al, 2018. This suggests the involvement of other genes in the susceptibility of AS.…”

Section: Interaction With the Status Of Hlab-27mentioning

confidence: 99%

Characterization of ERAP1 rs30187 and rs10050860 Polymorphisms and Their Association with Ankylosing Spondylitis in The Algerian Population Association of ERAP1 in Algeria

Asmaa

Boutarfaïa²,

Amroun³

et al. 2022

Egyptian Academic Journal of Biological Sciences. C, Physiology

View full text Add to dashboard Cite

Ankylosing spondylitis (AS) is chronic inflammatory rheumatism. The Endoplasmic Reticulum Aminopeptidase (ERAP1) gene is considered the second genetic factor associated with (AS) after HLA-B27. The aim of this study was to assess the role of ERAP1 rs30187 and rs10050860 polymorphisms in susceptibility to AS for the first time in the Algerian population. A total of one hundred sixteen controls and eighty-one AS cases were included in the present study. ERAP1 rs30187 and rs10050860 variants were determined by using the real-time polymerase chain reaction method. Differences in allele and genotype distribution between the cases and controls were tested with adjustment for age. A stratification of case and control groups by HLAB27, age (≤30 or >30), gender (male and female) and clinical characteristics were also performed. Statistical analyses were done using SPSS21.0. No statistically significant association was observed between ERAP1 rs30187 and rs10050860 polymorphisms and AS risk (p<0.025). However, stratification by age and gender showed that the minor allele of rs30187 reduces the risk of developing AS in women with age >30 (OR=0.13[0.04-0.39], p =6.10 -5 ), TT genotype (OR=0.09[0.01-0.6], p=5.10 -3 ) and dominant model (TT+CT) (OR=0.14[0.03-0.6], p= 4.10 -3 ) in a sample of the Algerian population. Indeed, in our study, ERAP1 rs10050860 polymorphism did not predispose us to AS in our population. For the first time, the allelic and genotypic frequencies of ERAP1gene polymorphisms in the Algerian population. This work enriches the library of information about the ERAP1 gene.

show abstract

“…I decided to critique a small part of it briefly, which is about the clinical relevance of HLA-B*27 polymorphisms in patients with ankylosing spondylitis (AS) in Asia. They included in their paper: "This is contrary to the findings reported for Asian populations, for whom HLA-B*27 polymorphisms may affect disease phenotype, particularly B*2704 and B*27015, which are associated with earlier disease onset and more frequent uveitis than B*2705 among Asian patients" [1]. One of the articles cited by Salmani and her colleagues on this subject is the article by Fallahi et al [2].…”

mentioning

confidence: 96%

“…To editor: I read the interesting paper entitled Spondyloarthritis in North Africa: an update which has been published by Silmani et al in clinical rheumatology [1]. I decided to critique a small part of it briefly, which is about the clinical relevance of HLA-B*27 polymorphisms in patients with ankylosing spondylitis (AS) in Asia.…”

mentioning

confidence: 99%

Are the earlier disease onset and uveitis affected by the HLA-B*27 subtypes in ankylosing spondylitis? Comments on the article by Silmani et al.

Fallahi

2021

Clin Rheumatol

View full text Add to dashboard Cite

Spondyloarthritis in North Africa: an update

Cited by 14 publications

References 72 publications

Knowledge, Attitudes, and Practices of Moroccan Community Rheumatologists’ Regarding the Management of Non-radiographic Axial Spondyloarthritis: A National Cross-Sectional Study

Knowledge, Attitudes, and Practices of Moroccan Community Rheumatologists’ Regarding the Management of Non-radiographic Axial Spondyloarthritis: A National Cross-Sectional Study

Characterization of ERAP1 rs30187 and rs10050860 Polymorphisms and Their Association with Ankylosing Spondylitis in The Algerian Population Association of ERAP1 in Algeria

Are the earlier disease onset and uveitis affected by the HLA-B*27 subtypes in ankylosing spondylitis? Comments on the article by Silmani et al.

Contact Info

Product

Resources

About