Spondweni Virus Infection in a Foreign Resident of Upper Volta

Wolfe, MartinS.; Calisher, CharlesH.; Mcguire, Karen

doi:10.1016/s0140-6736(82)91511-2

Cited by 33 publications

(28 citation statements)

References 8 publications

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“…Banzi and Spondweni viruses [37] are considered rare with only a few cases reported historically mostly in laboratory workers [38]. Spondwenivirus neurological infection in travellers to West Africa raised concern about its potential to emerge internationally [39]. Vector competence studies suggested low susceptibility to Aedes eagypti, A. albopictus and Culex quinquefasciatus [40].…”

Section: Other Flavivirusesmentioning

confidence: 99%

Assessing the zoonotic potential of arboviruses of African origin

Venter

2018

Current Opinion in Virology

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Several African arboviruses have emerged over the past decade in new regions where they caused major outbreaks in humans and/or animals including West Nile virus, Chikungunya virus and Zika virus. This raise questions regarding the importance of less known zoonotic arboviruses in local epidemics in Africa and their potential to emerge internationally. Syndromic surveillance in animals may serve as an early warning system to detect zoonotic arbovirus outbreaks. Rift Valley fever and Wesselsbronvirus are for example associated with abortion storms in livestock while West Nile-virus, Shuni virus and Middelburg virus causes neurological disease outbreaks in horses and other animals. Death in birds may signal Bagaza virus and Usutu virus outbreaks. This short review summarise data on less known arboviruses with zoonotic potential in Africa.

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Section: Other Flavivirusesmentioning

confidence: 99%

Assessing the zoonotic potential of arboviruses of African origin

Venter

2018

Current Opinion in Virology

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“…ZIKV is a mosquito-borne member of the Spondweni virus (SPOV) group. Both ZIKV and SPOV were known to cause limited, sporadic outbreaks in Africa and South East Asia (Haddow et al, 2012; Wolfe et al, 1982). However, ZIKV has emerged in the South Pacific and South and Central America associated with sustained transmission affecting an estimated 0.5 to 1.5 million people.…”

Section: Introductionmentioning

confidence: 99%

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

Grant

Ponia

Tripathi

et al. 2016

Cell Host & Microbe

686

770

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Summary The ongoing epidemic of Zika virus (ZIKV) illustrates the importance of flaviviruses as emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome type I interferon (IFN) to replicate and cause disease in vertebrates. The mechanism(s) by which ZIKV antagonizes IFN signaling is unknown. Here, we report that the nonstructural protein NS5 of ZIKV and other flaviviruses examined could suppress IFN signaling, but through different mechanisms. ZIKV NS5 expression resulted in proteasomal degradation of the IFN-regulated transcriptional activator STAT2 from humans but not mice, which may explain the requirement for IFN-deficiency to observe ZIKV-induced disease in mice. The mechanism of ZIKV NS5 resembles dengue virus (DENV) NS5 and not its closer relative, Spondweni virus (SPOV). However, unlike DENV, ZIKV did not require the E3 ubiquitin ligase UBR4 to induce STAT2 degradation. Hence, flavivirus NS5 proteins exhibit a remarkable functional convergence in IFN antagonism, albeit by virus-specific mechanisms.

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“…ZIKV and its phylogenetically closest relative Spondweni virus form the Spondweni virus group; both of which are known to infect humans [5, 6]. ZIKV virions are enveloped by a host cell-derived lipid bilayer membrane.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Systems Biology Approach to Studying Zika Virus

May

Relich

2016

PLoS ONE

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Zika virus (ZIKV) is responsible for an ongoing and intensifying epidemic in the Western Hemisphere. We examined the complete predicted proteomes, glycomes, and selectomes of 33 ZIKV strains representing temporally diverse members of the African lineage, the Asian lineage, and the current outbreak in the Americas. Derivation of the complete selectome is an ‘omics’ approach to identify distinct evolutionary pressures acting on different features of an organism. Employment of the M8 model did not show evidence of global diversifying selection acting on the ZIKV polyprotein; however, a mixed effect model of evolution showed strong evidence (P<0.05) for episodic diversifying selection acting on specific sites. Single nucleotide polymorphisms (SNPs) were predictably frequent across strains relative to the derived consensus sequence. None of the 9 published detection procedures utilize targets that share 100% identity across the 33 strains examined, indicating that ZIKV escape from molecular detection is predictable. The predicted O-linked glycome showed marked diversity across strains; however, the N-linked glycome was highly stable. All Asian and American strains examined were predicted to include glycosylation of E protein ASN154, a modification proposed to mediate neurotropism, whereas the modification was not predicted for African strains. SNP diversity, episodic diversifying selection, and differential glycosylation, particularly of ASN154, may have major biological implications for ZIKV disease. Taken together, the systems biology perspective of ZIKV indicates: a.) The recently emergent Asian/American N-glycotype is mediating the new and emerging neuropathogenic potential of ZIKV; and b.) further divergence at specific sites is predictable as endemnicity is established in the Americas.

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Spondweni Virus Infection in a Foreign Resident of Upper Volta

Cited by 33 publications

References 8 publications

Assessing the zoonotic potential of arboviruses of African origin

Assessing the zoonotic potential of arboviruses of African origin

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

A Comprehensive Systems Biology Approach to Studying Zika Virus

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