Abstract:whose mechanism is currently unknown. Experiments here were designed to test the hypothesis that the properties of Tn are important in determining the SL dependence of force in cardiac muscle. We compared trabeculae exchanged with WT cTn vs. cTn containing a mutant (L48Q) cTnC with enhanced Ca 2þ affinity. L48Q cTnC caused a left-shift in the force-pCa relationship at long (2.3 mm) SL as compared to WT cTnC. Interestingly, L48Q cTnC effectively eliminated SL-dependence of the force-pCa relationship, via a much… Show more
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