Splitting the dose of neonatal BCG vaccination: a naïve practice

Fretzayas, Andrew; Moustaki, Maria; Stefos, Efstathios; Nicolaidou, Polyxeni

doi:10.1179/027249309x12467994694210

Cited by 1 publication

(1 citation statement)

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“…Several factors are involved in causing these complications, including dosage, age of vaccination, place of vaccination, method of injection, method of preparation of vaccine, brand, characteristics of the subjects studied and skills of the individuals, who inject the vaccine (13). In the study of Fretzayas et al, although the dose was divided to 0.025 ML in both arms, the incidence of lymphadenitis did not decrease and in some cases bilateral lymphadenitis occurred (19). Another study confirmed that the type and strain of vaccine was considered to be effective in the incidence of lymphadenitis, and they believed that a change in the strain of vaccine would be effective (20).…”

Section: Discussionmentioning

confidence: 95%

Complications of Bacillus Calmette-Guérin Vaccination at a University Hospital in Iranian Neonates

Siroosbakht¹,

Rezakhaniha²

2018

J Compr Ped

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Background: The most common complications of Bacillus Calmette-Guérin (BCG) vaccine are lymphadenopathy, lymphadenitis, abscess, and fistula. These occur in less than one percent of vaccinated individuals. The aim of this study was to determine the frequency of these side-effects in Iranian neonates at a university hospital. Objectives: The researchers decided to study the new results of BCG vaccine complications at the university center and compare them with previous results from Iran and other countries until the relative position of Iran was identified. Methods: In a prospective, descriptive-analytical study with the census method, 214 neonates at Golestan Hospital of Tehran, Iran from May 2015 to Jan 2018 were studied. Bacillus Calmette-Guérin vaccination was performed for all these neonates at the hospital. The neonates were examined on a monthly basis by a physician and the questionnaires were completed. Results: In this study, the rate of lymphadenopathy, lymphadenitis, and fistulization of the abscess after BCG vaccination were 2.5%, 0.5%, and 0%, respectively. No significant difference was observed between gender and age of the infants and the occurrence of the complications (P > 0.05). Conclusions: This study showed a higher rate of lymphadenopathy and lymphadenitis after BCG vaccination compared with other studied countries. Various factors are involved in making this difference, such as inaccuracy in the injection site and injection method, improper dilution and type of vaccine manufacturer, and a more immunogenic vaccine (Pasteur Company, Tehran). Therefore, health authorities should help reduce the incidence of complications of BCG vaccination with continuous education of the vaccination unit personnel, monitoring the preservation and method of vaccine preparation and change of the vaccine strain.

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Section: Discussionmentioning

confidence: 95%