Split-Thickness Skin Graft Attachment to Bone Lacking Periosteum

Tran, Lynn E.; Berry, Gerald J.; Fee, Willard E.

doi:10.1001/archotol.131.2.124

Cited by 7 publications

(5 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…38 Although the results showed that VEGF can improve take of skin graft in a rich vascularized recipient bed, 39 the effect of VEGF on graft survival is more significant when skin grafting on a recipient bed with poor blood supply.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Full-Thickness Skin Graft Survival by Application of Vascular Endothelial Growth Factor in Rats

Zhang

Oswald

Lin

et al. 2008

Annals of Plastic Surgery

View full text Add to dashboard Cite

The effect of vascular endothelial growth factor (VEGF) on skin graft survival was studied in rats. Models of skin grafting on muscle and periosteum were designed. For the study of skin grafting on muscle model, 32 rats were divided into 4 groups. VEGF was administrated systemically after skin graft placement intrafascially injected into the recipient bed at the time of graft placement and topically applied to the recipient bed at the time of graft placement. Control groups consisted of grafts placed on sites without systemic or local VEGF treatment. With the study of skin grafting on periosteum, 40 rats were divided into 4 groups. VEGF was systemically, intraperiosteally, and topically applied to the recipient bed. The control animals received no treatment. On the fifth postoperative day, the survival area of each skin graft was measured and the graft was harvested for histology with CD31 immunohistochemical staining. The results showed that in skin grafting on muscle model, the mean viable percentage of the skin graft was 66.1% +/- 10.2% in the group receiving systemic application of VEGF and 56.1% +/- 9.8% in the group receiving VEGF intrafascia injection. The survival percentages were significantly higher than those found in the control group (22.5% +/- 7.7%) and the group with VEGF topical application (30.8% +/- 4.1%). In skin grafting on periosteum, the group receiving VEGF intraperiosteum injection reached a survival percentage of 50.5% +/- 4.3%, significantly higher than the groups with VEGF systemic application (28.7 +/- 5.5%), VEGF topical application (32.5% +/- 4.8%), and the control (25.8% +/- 6.0%). Histology showed that sections taken from grafts with VEGF intrafascia and intraperiosteum treatment revealed angiogenesis. The data demonstrated that administration of VEGF into the either muscular or periosteal recipient beds for skin grafting can improve the skin graft survival.

show abstract

Section: Discussionmentioning

confidence: 99%

Improvement of Full-Thickness Skin Graft Survival by Application of Vascular Endothelial Growth Factor in Rats

Zhang

Oswald

Lin

et al. 2008

Annals of Plastic Surgery

View full text Add to dashboard Cite

show abstract

“…Crusting may lead to nasal obstruction and a foul odour, requiring frequent saline rinsing (Figure 6). Others have noted that graft survival rates are high within the well protected nasal cavity 15 . A literature search identified no reports of increased rates of squamous cell carcinoma in the nasal cavity.…”

Section: Discussionmentioning

confidence: 99%

Modified nasal dermoplasty technique for treatment of recurrent polyposis: preliminary results

Anastasopoulos¹,

Grigoriadis²,

Papoutsi³

2013

J. Laryngol. Otol.

View full text Add to dashboard Cite

show abstract

“…Therefore, we placed a thin flap and subsequently performed nail bed grafting. However, it is not always necessary to perform a two-stage operation in all cases with bone exposure, because grafting the nail bed on the periosteum can provide a result that is better than expected [8]. In our cases, we placed a nail bed graft over the exposed bone when the defect was relatively small.…”

Section: Methodsmentioning

confidence: 99%

Long-term outcomes of nail bed reconstruction

et al. 2019

View full text Add to dashboard Cite

Background There are various reconstructive options for nail bed defects. However, it is challenging not to leave a deformity. In this study, we investigated differences in outcomes depending on the reconstruction method, attempted to determine which method was better, and analyzed other factors that may affect outcomes. Methods The long-term outcomes of nail bed reconstruction were reviewed retrospectively. We performed three types of reconstruction depending on the defect type: composite grafts of severed segments, nail bed grafts from the big toe, and two-stage surgery (flap coverage first, followed by a nail bed graft). Subsequent nail growth was evaluated during follow-up, and each outcome was graded based on Zook's criteria. The reconstruction methods were statistically analyzed. Other factors that could contribute to the outcomes, including age, the timing of surgery, germinal matrix involvement, defect size, and the presence of bone injuries, were also compared. Results Twenty-one patients (22 digits) who underwent nail bed reconstruction were evaluated. The type of reconstruction method did not show a significant relationship with the outcomes. However, patients who sustained injuries in the germinal matrix and patients with a defect larger than half the size of the nail bed had significantly worse outcomes than the comparison groups. Conclusions The results suggest that no operative method was superior to another in terms of the outcomes of nail bed reconstruction. Nevertheless, involvement of the germinal matrix and defect size affected the outcomes.

show abstract

Split-Thickness Skin Graft Attachment to Bone Lacking Periosteum

Abstract: To develop an animal model to investigate the survival of split-thickness skin grafts (STSGs) on bone without periosteum, to compare STSG attachment to bone with and without periosteum, and to determine the effect of fibrin glue on STSG attachment to bone.

Cited by 7 publications

References 14 publications

Improvement of Full-Thickness Skin Graft Survival by Application of Vascular Endothelial Growth Factor in Rats

Improvement of Full-Thickness Skin Graft Survival by Application of Vascular Endothelial Growth Factor in Rats

Modified nasal dermoplasty technique for treatment of recurrent polyposis: preliminary results

Long-term outcomes of nail bed reconstruction

Contact Info

Product

Resources

About