Split renal function in patients with renal masses: utility of parenchymal volume analysis vs nuclear renal scans

Ye, Yunlin; Tanaka, Hajime; Wang, Yanbo; Campbell, Rebecca A.; Palacios, Diego Aguilar; DeWitt-Foy, Molly; Mahmood, Furman; Eltemamy, Mohamed; Remer, Erick M.; Li, Jianbo; Campbell, Steven C.

doi:10.1111/bju.14997

Cited by 25 publications

(33 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Now such measurements are facilitated by readily available software that provides highly accurate estimates of tumour and parenchymal volumes. Incorporation of direct measurements of vascularized parenchymal volumes into the analyses confirmed the results of the initial studies, and the relationship between parenchymal volume saved and function saved after PN was even stronger, nearly 1–1, reflecting more accurate estimation of the input parameters [22–26].…”

Section: New Perspectives On Ischaemia: the Importance Of Parenchymal...mentioning

confidence: 71%

Every decade counts: a narrative review of functional recovery after partial nephrectomy

Campbell

Campbell²,

Muñoz-López

et al. 2022

BJU International

Self Cite

View full text Add to dashboard Cite

To provide a narrative review of the major advances regarding ischaemia and functional recovery after partial nephrectomy (PN), along with the ongoing controversies. MethodsKey articles reflecting major advances regarding ischaemia and functional recovery after PN were identified. Special emphasis was placed on contributions that changed perspectives about surgical management. Priority was also placed on randomized trials of off-clamp vs on-clamp cohorts. ResultsA decade ago, 'Every minute counts' was published, showing strong correlations between duration of ischaemia and development of acute kidney injury (AKI) and chronic kidney disease after clamped PN. This reinforced perspectives that ischaemia was the main modifiable factor that could be addressed to improve functional outcomes and helped spur efforts towards reduced or zero ischaemia PN. These approaches were associated with strong functional recovery and some peri-operative risk, although they were generally safe in experienced hands. Further research demonstrated that, when parenchymal volume changes were incorporated into the analyses, ischaemia lost statistical significance, and percent parenchymal volume saved proved to be the main determinant. Cold ischaemia was confirmed to be highly protective, and limited warm ischaemia also proved to be safe. The reconstructive phase of PN, with avoidance of parenchymal devascularization, appears to be most important for functional outcomes. Randomized trials of on-clamp vs off-clamp PN have shown minimal impact of ischaemia on functional recovery. ConclusionsThe past decade has witnessed great progress regarding functional recovery after PN, with many lessons learned. However, there are still unanswered questions, including: What is the threshold of warm ischaemia at which irreversible ischaemic injury begins to develop? Are some cohorts at increased risk for AKI or irreversible ischaemic injury? and Which patients should be prioritized for zero-ischaemia PN?

show abstract

Section: New Perspectives On Ischaemia: the Importance Of Parenchymal...mentioning

confidence: 71%

Every decade counts: a narrative review of functional recovery after partial nephrectomy

Campbell

Campbell²,

Muñoz-López

et al. 2022

BJU International

Self Cite

View full text Add to dashboard Cite

show abstract

“…For instance, large and likely aggressive tumors tend to compromise a greater amount of healthy renal parenchyma, resulting in decreased split renal function of the ipsilateral kidney in comparison with the contralateral kidney, as evidenced in several studies from our group and others. 19–21…”

Section: Discussionmentioning

confidence: 99%

New Baseline Renal Function after Radical or Partial Nephrectomy: A Simple and Accurate Predictive Model

et al. 2021

View full text Add to dashboard Cite

“…The greater the loss of renal parenchyma, the more severe the loss of renal function 10 . Ye et al 11 . showed that renal PV analysis may be of great practical value in estimating renal mitotic function, thus eliminating the need for nuclear renal scanning.…”

Section: Discussionmentioning

confidence: 99%

Ability of volume measures of hydronephrosis to predict need for surgery and evaluate renal function in children with ureteropelvic junction obstruction

et al. 2021

View full text Add to dashboard Cite

Objective To explore the efficacy of quantitative renal volume measures on magnetic resonance urography images in predicting need for surgery among children with ureteropelvic junction obstruction and their ability to evaluate renal function. Methods A total of 88 cases of hydronephrosis in 50 patients were collected between 1 April 2018 and 31 March 2020, including 30 operated kidney and 58 unoperated kidney cases. Clinical data were collected, and quantitative analysis of magnetic resonance urography was performed. Renal volume, hydronephrosis volume and the volume ratio of hydronephrosis (hydronephrosis volume/renal volume) were measured and calculated. We analyzed the relationships between the above indices in the two groups and compared these with renal function. Results Compared with the unoperated kidney group, hydronephrosis volume, renal volume and hydronephrosis volume/renal volume of the operated kidney group increased significantly. Hydronephrosis volume (area under the curve 0.972, 95% confidence interval 0.943–1.000; P < 0.001) and hydronephrosis volume/renal volume (area under the curve 0.968, 95% confidence interval 0.939–0.998; P < 0.001) were superior to ultrasonography and renal function examination in predicting the probability of surgery, and their sensitivity values (hydronephrosis volume/renal volume: 96.67%; hydronephrosis volume: 93.33%) were higher than those of the renal function test (50%). There was a significant difference among different renal function groups in the pairwise comparison of hydronephrosis volume and hydronephrosis volume/renal volume (P < 0.05). Conclusion Quantitative volume measures of hydronephrosis by magnetic resonance urography had a greater ability to predict need for surgery than ultrasonography and dynamic renal imaging, and it can be used as method by which to evaluate surgery. Hydronephrosis volume and hydronephrosis volume/renal volume have greater predictive ability, and play an important role in the deterioration of renal function.

show abstract

Split renal function in patients with renal masses: utility of parenchymal volume analysis vs nuclear renal scans

Cited by 25 publications

References 28 publications

Every decade counts: a narrative review of functional recovery after partial nephrectomy

Every decade counts: a narrative review of functional recovery after partial nephrectomy

New Baseline Renal Function after Radical or Partial Nephrectomy: A Simple and Accurate Predictive Model

Ability of volume measures of hydronephrosis to predict need for surgery and evaluate renal function in children with ureteropelvic junction obstruction

Contact Info

Product

Resources

About