Split Proteins and Reassembly Modules for Biological Applications
Jieun Bae,
Jonghoon Kim,
Jongdoo Choi
et al.
Abstract:Split systems, modular entities enabling controlled biological processes, have become instrumental in biological research. This review highlights their utility across applications like gene regulation, protein interaction identification, and biosensor development. Covering significant progress over the last decade, it revisits traditional split proteins such as GFP, luciferase, and inteins, and explores advancements in technologies like Cas proteins and base editors. We also examine reassembly modules and thei… Show more
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