Split-Mouth Comparison of Coronally Advanced Flap with Connective Tissue Graft or Collagen Matrix for Treatment of Isolated Gingival Recessions

Matoh, Urban; Petelin, Milan; Gašperšič, Rok

doi:10.11607/prd.3562

Cited by 7 publications

(8 citation statements)

References 9 publications

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“…Hence, 100% of the articles analysed in this study support the statement that Col can be used for gingival healing [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. However, 13% of the researchers emphasise that Col has less potential for GR healing compared with SCTG [ 14 , 18 ]. Two studies in this review analysed the physicochemical properties of the Col-based scaffold and the effect of the scaffold in GR [ 11 , 12 ].…”

Section: Discussionsupporting

confidence: 71%

“…In order to accommodate this problem from worsening, recent advancement in biomaterials is considerable as it has high biocompatible properties to human nature. Many studies have used Col-based scaffolds to study its effects in gingival healing using in vitro models [ 11 , 12 ], in vivo models [ 13 , 14 , 15 , 16 ], and clinical trials [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Current Insight of Collagen Biomatrix for Gingival Recession: An Evidence-Based Systematic Review

2020

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Collagen (Col) is a naturally available material and is widely used in the tissue engineering and medical field owing to its high biocompatibility and malleability. Promising results on the use of Col were observed in the periodontal application and many attempts have been carried out to inculcate Col for gingival recession (GR). Col is found to be an excellent provisional bioscaffold for the current treatment in GR. Therefore, the aim of this paper is to scrutinize an overview of the reported Col effect focusing on in vitro, in vivo, and clinical trials in GR application. A comprehensive literature search was performed using EBSCOhost, Science Direct, Springer Link, and Medline & Ovid databases to identify the potential articles on particular topics. The search query was accomplished based on the Boolean operators involving keywords such as (1) collagen OR scaffold OR hybrid scaffold OR biomaterial AND (2) gingiva recession OR tissue regeneration OR dental tissue OR healing mechanism OR gingiva. Only articles published from 2015 onwards were selected for further analysis. This review includes the physicochemical properties of Col scaffold and the outcome for GR. The comprehensive literature search retrieved a total of 3077 articles using the appropriate keywords. However, on the basis of the inclusion and exclusion criteria, only 15 articles were chosen for further review. The results from these articles indicated that Col promoted gingival tissue regeneration for GR healing. Therefore, this systematic review recapitulated that Col enhances regeneration of gingival tissue either through a slow or rapid process with no sign of cytotoxicity or adverse effect.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Current Insight of Collagen Biomatrix for Gingival Recession: An Evidence-Based Systematic Review

2020

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“…In addition, the literature proved that OsteoBiol ® materials could be used alone or in combination both for the regeneration of bone defects and soft tissue augmentation. For example, in the latter case, membranes, such as Derma, can be used alone as an alternative to connective tissue graft to improve the quality of keratinized tissues [ 166 , 171 , 172 , 173 , 174 ]. Apatos ® , instead, is a universal filler that can be employed to treat peri-implant defects and two-wall defects [ 68 , 74 ].…”

Section: Discussionmentioning

confidence: 99%

A Narrative Review on the Effectiveness of Bone Regeneration Procedures with OsteoBiol® Collagenated Porcine Grafts: The Translational Research Experience over 20 Years

Romasco

Tumedei

Inchingolo

et al. 2022

JFB

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Over the years, several bone regeneration procedures have been proposed using natural (autografts, allografts, and xenografts) and synthetic (i.e., metals, ceramics, and polymers) bone grafts. In particular, numerous in vitro and human and animal in vivo studies have been focused on the discovery of innovative and suitable biomaterials for oral and maxillofacial applications in the treatment of severely atrophied jaws. On this basis, the main objective of the present narrative review was to investigate the efficacy of innovative collagenated porcine bone grafts (OsteoBiol®, Tecnoss®, Giaveno, Italy), designed to be as similar as possible to the autologous bone, in several bone regeneration procedures. The scientific publications were screened by means of electronic databases, such as PubMed, Scopus, and Embase, finally selecting only papers that dealt with bone substitutes and scaffolds for bone and soft tissue regeneration. A total of 201 papers have been detected, including in vitro, in vivo, and clinical studies. The effectiveness of over 20 years of translational research demonstrated that these specific porcine bone substitutes are safe and able to improve the biological response and the predictability of the regenerative protocols for the treatment of alveolar and maxillofacial defects.

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“…Various collagen-based soft tissue substitute materials have been introduced in periodontal and peri-implant soft tissue reconstructive surgery. A number of clinical studies comparing autogenous CTGs with collagen-based matrices have noted the superiority of the autografts, especially in achieving an optimal thickness of the regenerated tissue [ 2 , 5 , 15 , 16 , 17 , 18 , 19 , 49 ]. The present study focused on a highly porous, volume-stable collagen matrix [ 21 , 23 , 24 , 25 , 26 , 27 , 28 ], which is able to overcome the volume-stability limitation of most commercially available grafts.…”

Section: Discussionmentioning

confidence: 99%

“…A number of clinical studies have demonstrated the successful application of acellular collagen matrices in periodontal surgical reconstructions, with low patient morbidity [ 10 , 11 , 12 , 13 , 14 , 15 ]. Although collagen matrices are considered the graft substitutes providing the most similar outcomes to the autogenous CTGs, the majority of clinical studies comparing the two graft types have demonstrated the superiority of the CTGs, particularly in the treatment of gingival recessions [ 2 , 5 , 16 , 17 , 18 ] as well as in soft tissue augmentation procedures for increasing the width of keratinized tissue [ 15 , 19 ]. Thus, a comparison of an acellular dermal allograft with an autogenous CTG, both combined with coronally advanced flap in the treatment of surgically created Miller Class I recession defects, demonstrated a significantly higher gingival thickness in the CTG group, in spite of a similar graph thickness (1 mm) at the time of the surgical placement [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Volume-Stable Collagen Matrix Induces Changes in the Behavior of Primary Human Oral Fibroblasts, Periodontal Ligament, and Endothelial Cells

Asparuhova

Stähli

Guldener

et al. 2021

IJMS

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The aim of the present study was to investigate the influence of a novel volume-stable collagen matrix (vCM) on early wound healing events including cellular migration and adhesion, protein adsorption and release, and the dynamics of the hemostatic system. For this purpose, we utilized transwell migration and crystal violet adhesion assays, ELISAs for quantification of adsorbed and released from the matrix growth factors, and qRT-PCR for quantification of gene expression in cells grown on the matrix. Our results demonstrated that primary human oral fibroblasts, periodontal ligament, and endothelial cells exhibited increased migration toward vCM compared to control cells that migrated in the absence of the matrix. Cellular adhesive properties on vCM were significantly increased compared to controls. Growth factors TGF-β1, PDGF-BB, FGF-2, and GDF-5 were adsorbed on vCM with great efficiency and continuously delivered in the medium after an initial burst release within hours. We observed statistically significant upregulation of genes encoding the antifibrinolytic thrombomodulin, plasminogen activator inhibitor type 1, thrombospondin 1, and thromboplastin, as well as strong downregulation of genes encoding the profibrinolytic tissue plasminogen activator, urokinase-type plasminogen activator, its receptor, and the matrix metalloproteinase 14 in cells grown on vCM. As a general trend, the stimulatory effect of the vCM on the expression of antifibrinolytic genes was synergistically enhanced by TGF-β1, PDGF-BB, or FGF-2, whereas the strong inhibitory effect of the vCM on the expression of profibrinolytic genes was reversed by PDGF-BB, FGF-2, or GDF-5. Taken together, our data strongly support the effect of the novel vCM on fibrin clot stabilization and coagulation/fibrinolysis equilibrium, thus facilitating progression to the next stages of the soft tissue healing process.

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Split-Mouth Comparison of Coronally Advanced Flap with Connective Tissue Graft or Collagen Matrix for Treatment of Isolated Gingival Recessions

Cited by 7 publications

References 9 publications

Current Insight of Collagen Biomatrix for Gingival Recession: An Evidence-Based Systematic Review

Current Insight of Collagen Biomatrix for Gingival Recession: An Evidence-Based Systematic Review

A Narrative Review on the Effectiveness of Bone Regeneration Procedures with OsteoBiol® Collagenated Porcine Grafts: The Translational Research Experience over 20 Years

A Novel Volume-Stable Collagen Matrix Induces Changes in the Behavior of Primary Human Oral Fibroblasts, Periodontal Ligament, and Endothelial Cells

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