Split dosing with a low-volume preparation is not inferior to split dosing with a high-volume preparation for bowel cleansing in patients with a history of colorectal resection: a randomized trial

Abstract

ClinicalTrial.gov identifier NCT01887158.

Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non‐inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid

“…9,10 To reduce the volume of PEG, additional studies on giving 2 L PEG with oral bisacodyl have been conducted. [11][12][13][14][15] However, the safety and efficacy of 2 L low-volume PEG formulation containing ascorbic acid (2L PEG-Asc) is not significantly different from that of conventional 4 L PEG. [16][17][18][19][20] Therefore, many domestic and international hospitals are currently using 2L PEG-Asc.…”

Split‐dose 4‐L polyethylene glycol regimen for patients with previous colorectal surgery in bowel preparation before colonoscopy: A randomized, controlled, single‐blind study

“…Hence, we assessed the quality of bowel preparation in only the remaining colonic segments according to the segment score other than the total mBBPS score. Each endoscopist had been trained for the use of the Aronchick score and mBBPS score through illustrations, booklets and the interpretation of a few visual examples …”

“…According to the previous studies and our clinical experiences, we conservatively estimated that the proportion of successful bowel preparation was 75% in the 2‐MO group in our study. In comparison, a successful bowel preparation can be achieved in approximately 91.6% of patients with colorectal resection in the Western countries with a 4‐L PEG regimen . Thus, the proportion of successful bowel preparation in an Asian population who had undergone previous colorectal surgery was revised to up to 92% in the 4‐SD group.…”

“…Each endoscopist had been trained for the use of the Aronchick score and mBBPS score through illustrations, booklets and the interpretation of a few visual examples. 21…”

“…In comparison, a successful bowel preparation can be achieved in approximately 91.6% of patients with colorectal resection in the Western countries with a 4-L PEG regimen. 21 Thus, the proportion of successful bowel preparation in an Asian population who had undergone previous colorectal surgery was revised to up to 92% in the 4-SD group. Allowing for a drop-out rate of 10%, a sample size of 160 patients (80 per group) would achieve 80% power to detect a significant difference between the two groups, with a significance level (α) of 0.05.…”