Abstract:SynGAP-a1 is a splice variant of the neurodevelopmental disorder risk gene, SYNGAP1/Syngap1. a1 encodes the C-terminal PDZ binding motif (PBM) that promotes liquidliquid phase separation, a candidate process for postsynaptic density organization within excitatory synapses. However, it remains unknown how the endogenous SynGAP PBM regulates synapse properties and related cognitive functions. We found that a major PBM function in mice is to limit the mobility of SynGAP-a1 in response to NMDA receptor activation.… Show more
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