Splicing factors as regulators of miRNA biogenesis – links to human disease

Ratnadiwakara, Madara; Mohenska, Monika; Änkö, Minna‐Liisa

doi:10.1016/j.semcdb.2017.10.008

Cited by 54 publications

(51 citation statements)

References 147 publications

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“…Increasing evidence suggests that general RBPs, including splicing factors and other diverse RNA processing factors, act as post-transcriptional regulators of miRNA processing (for review, see Ratnadiwakara et al 2018). In such a scenario, the binding of an RBP to the TL or a stem of a miRNA progenitor can positively or negatively affect the Microprocessor-mediated processing of pri-miRNA in the nucleus, and/or the DICER-mediated processing of a pre-miRNA in the cytoplasm (Fig.…”

Section: Role Of Rbps In the Regulation Of Mirna Biogenesismentioning

confidence: 99%

Post-transcriptional control of miRNA biogenesis

Michlewski

Cáceres

2018

RNA

433

330

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MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear and cytoplasmic processing events, carried out by the endoribonucleases DROSHA and DICER, respectively, to produce mature miRNAs that are loaded onto the RISC (RNA-induced silencing complex) to exert their biological function. Regulation of mature miRNA levels is critical in development, differentiation, and disease, as demonstrated by multiple levels of control during their biogenesis cascade. Here, we will focus on post-transcriptional mechanisms and will discuss the impact of cis-acting sequences in precursor miRNAs, as well as transacting factors that bind to these precursors and influence their processing. In particular, we will highlight the role of general RNA-binding proteins (RBPs) as factors that control the processing of specific miRNAs, revealing a complex layer of regulation in miRNA production and function.

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Section: Role Of Rbps In the Regulation Of Mirna Biogenesismentioning

confidence: 99%

Post-transcriptional control of miRNA biogenesis

Michlewski

Cáceres

2018

RNA

433

330

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“…hnRNPs are a prominent splicing factor family known to be methylated on arginine residues [ 163 – 165 ]. Serine–arginine rich (SR) splicing factors are another prominent splicing factor family [ 166 ] and it should come as no surprise that SR splicing factors are methylated due to the abundance of arginine residues they contain. The SR protein SF2A-p32 associates with PRMT1 and PRMT5 [ 167 ], while PRMT2 associates with multiple SR proteins and hnRNPs, including Sam68, to regulate alternative splicing of the mitochondrial protein Bcl-x [ 168 ].…”

Section: Protein Arginine Methylationmentioning

confidence: 99%

Protein arginine methylation: an emerging regulator of the cell cycle

Raposo¹,

Piller²

2018

Cell Div

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Protein arginine methylation is a common post-translational modification where a methyl group is added onto arginine residues of a protein to alter detection by its binding partners or regulate its activity. It is known to be involved in many biological processes, such as regulation of signal transduction, transcription, facilitation of protein–protein interactions, RNA splicing and transport. The enzymes responsible for arginine methylation, protein arginine methyltransferases (PRMTs), have been shown to methylate or associate with important regulatory proteins of the cell cycle and DNA damage repair pathways, such as cyclin D1, p53, p21 and the retinoblastoma protein. Overexpression of PRMTs resulting in aberrant methylation patterns in cancers often correlates with poor recovery prognosis. This indicates that protein arginine methylation is also an important regulator of the cell cycle, and consequently a target for cancer regulation. The effect of protein arginine methylation on the cell cycle and how this emerging key player of cell cycle regulation may be used in therapeutic strategies for cancer are the focus of this review.

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“…This enhances tumor migration, invasion, and growth [ 94 ]. In various diseases (including cancers), deregulation of microRNAs is commonly associated with deregulation of splicing factors such as SR proteins and hnRNPs [ 95 ].…”

Section: Post-transcriptional Processes In the Mrna Life-cyclementioning

confidence: 99%

“…Termination of mRNA export is linked to translation and mRNA turnover [ 116 , 117 ]. Splicing factors are able to control translation regulation through the control of microRNA biogenesis [ 95 ]. Moreover, it has recently emerged that RNA processing and DNA damage response (DDR) are able to influence each other through the role of some factors involved in alternative splicing [ 49 , 50 ].…”

Section: Interplay Between the Different Stages Of Mrna Life-cyclementioning

confidence: 99%

Messenger RNA Life-Cycle in Cancer Cells: Emerging Role of Conventional and Non-Conventional RNA-Binding Proteins?

Coppin

Leclerc

Vincent

et al. 2018

IJMS

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Functional specialization of cells and tissues in metazoans require specific gene expression patterns. Biological processes, thus, need precise temporal and spatial coordination of gene activity. Regulation of the fate of messenger RNA plays a crucial role in this context. In the present review, the current knowledge related to the role of RNA-binding proteins in the whole mRNA life-cycle is summarized. This field opens up a new angle for understanding the importance of the post-transcriptional control of gene expression in cancer cells. The emerging role of non-classic RNA-binding proteins is highlighted. The goal of this review is to encourage readers to view, through the mRNA life-cycle, novel aspects of the molecular basis of cancer and the potential to develop RNA-based therapies.

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Splicing factors as regulators of miRNA biogenesis – links to human disease

Cited by 54 publications

References 147 publications

Post-transcriptional control of miRNA biogenesis

Post-transcriptional control of miRNA biogenesis

Protein arginine methylation: an emerging regulator of the cell cycle

Messenger RNA Life-Cycle in Cancer Cells: Emerging Role of Conventional and Non-Conventional RNA-Binding Proteins?

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