Splice variants of zinc finger protein 695 mRNA associated to ovarian cancer

Juárez-Méndez, Sergio; Zentella‐Dehesa, Alejandro; Villegas-Ruíz, Vanessa; Pérez-González, Oscar; Salcedo, Mauricio; López-Romero, Ricardo; Román-Basaure, Edgar; Lazos-Ochoa, Minerva; Oca-Fuentes, Víctor Edén Montes de; Vázquez-Ortíz, Guelaguetza; Moreno, José

doi:10.1186/1757-2215-6-61

Cited by 18 publications

(24 citation statements)

References 46 publications

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“…The upregulation of the isoforms in malignant tissue seemed to occur simultaneously rather than through a variant switch mechanism. The differential expression of KRAB-ZNF splicing isoforms in cancer was reported only by Juarez-Mendez and colleagues (Juarez-Mendez et al, 2013), who demonstrated a specific increase of ZNF695 variants in ovarian cancer compared to normal cells. Interestingly, we frequently observed increased expression of the variants that are not translated to a protein or are short forms devoid of KRAB or zinc finger domains.…”

Section: Discussionmentioning

confidence: 95%

“…Nevertheless, their exact molecular functions remain unknown. This includes ZNF695 (Juarez- Mendez et al, 2013;Li et al, 2015Takahashi et al, 2015), ZNF320 (Chernova et al, 2001), ZNF138 (Tommerup and Vissing, 1995), ZNF200 (Peedicayil et al, 2010), ZNF707 (Nesslinger et al, 2007), and ZNF354A (von Eyben, 2004). Interestingly, cancer-related upregulation of ZNF695, ZNF714, and ZNF138 mirrors the differential expression observed between pluripotent stem cells and differentiated cells (Oleksiewicz et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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The expression signature of cancer‐associated KRAB‐ZNF factors identified in TCGA pan‐cancer transcriptomic data

et al. 2019

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The KRAB ‐ ZNF (Krüppel‐associated box domain zinc finger) gene family is composed of a large number of highly homologous genes, gene isoforms, and pseudogenes. The proteins encoded by these genes, whose expression is often tissue‐specific, act as epigenetic suppressors contributing to the addition of repressive chromatin marks and DNA methylation. Due to its high complexity, the KRAB ‐ ZNF family has not been studied in sufficient detail, and the involvement of its members in carcinogenesis remains mostly unexplored. In this study, we aimed to provide a comprehensive description of cancer‐associated KRAB ‐ ZNF s using publicly available The Cancer Genome Atlas pan‐cancer datasets. We analyzed 6727 tumor and normal tissue samples from 16 cancer types. Here, we showed that a small but distinctive cluster of 16 KRAB ‐ ZNF s is commonly upregulated across multiple cancer cohorts in comparison to normal samples. We confirmed these observations in the independent panels of lung and breast cancer cell lines and tissues. This upregulation was also observed for most of the KRAB ‐ ZNF splicing variants, whose expression is simultaneously upregulated in tumors compared to normal tissues. Finally, by analyzing the clinicopathological data for breast and lung cancers, we demonstrated that the expression of cancer‐associated KRAB ‐ ZNF s correlates with patient survival, tumor histology, and molecular subtyping. Altogether, our study allowed the identification and characterization of KRAB ‐ ZNF factors that may have an essential function in cancer biology and thus potential to become novel oncologic biomarkers and treatment targets.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

The expression signature of cancer‐associated KRAB‐ZNF factors identified in TCGA pan‐cancer transcriptomic data

et al. 2019

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“…This C2H2 is the most characteristic zinc nger so far and is very common in mammal transcription factors [11]. It has been con rmed that different members of zinc nger proteins, such as ZNF608 [12], ZNF695 [13], ZEB1 [14] and Snail [15], are reported to be involved in the development and metastasis of OC, suggesting that zinc nger proteins may play an important role in OC. Compared with the welldocumented zinc nger protein members, the biological function and role of ZNF280A in OC has been poorly reported.…”

Section: Introductionmentioning

confidence: 94%

Knockdown of ZNF280A inhibits the development and progression of ovarian cancer

Zhu

et al. 2020

Preprint

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Background: Ovarian cancer (OC) is one of the leading causes of death from gynecological malignancies worldwide. Abnormal expression of zinc finger proteins has been extensively reported to be involved in malignant progression in a variety of cancers. However, clinical significance and biological roles of ZNF280A in the field of OC are poorly known. Methods: In this study, we demonstrated that ZNF280A was highly expressed in OC tissues compared with adjacent normal tissues. Further, ZNF280A was significantly associated with clinical staging, infiltration, lymphatic metastasis, metastasis, and tumor recurrence of OC patients. Additionally, data of in vitro experiments indicated that knockdown of ZNF280A by its shRNA dramatically reduces the proliferation and migration ability of OC cells, while enhancing the cell apoptosis. Results: It was also verified by animal experiments that ZNF280A silencing would affect the growth of OC in vivo. Our study investigated the involvement of ZNF280A in the prognosis, progression and metastasis of OC. Conclusions: Therefore, our study identified ZNF280A as an optional prognostic factor in OC patients and can be used as a potential therapeutic target for the treatment of OC.

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“…The data were download of ArrayExpress (https://www.ebi.ac.uk/ arrayexpress/) [44] or Gene Expression Omnibus (GEO) (https://www.ncbi.nlm.nih.gov/geo/) [45]. The microarray analysis was performed using Partek Genomics Suite v7.17 according to previous reports [46].…”

Section: Alternative Splicing In the Most Common Cancer Typesmentioning

confidence: 99%

Alternative RNA Splicing: New Approaches for Molecular Marker Discovery in Cancer

Villegas-Ruíz¹,

Juárez-Méndez²

2018

Bioinformatics in the Era of Post Genomics and Big Data

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In cancer, several alterations driving cell transformation including: imbalances DNA, changes in gene expression as well as protein diversity. The transcriptional regulation is finely driving and controlled by a large number of molecules, including: SR proteins, hnRNPS, RNA, DNA, histones methylation, among others. However, in cancer the regulation is altered. It is little kwon regulations causing alternative splicing in healthy and human diseases. The alternative splicing plays an important role in the generation of diversity of transcripts its proteins resulting. The aberrant transcripts variants expressed in cancer have shown a great potential as biomarkers or therapeutics targets. In this manuscript, we showed the basic in alternative splicing and a simple method using available data for detection alternative transcripts expressed in the tree most common human cancer.

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Splice variants of zinc finger protein 695 mRNA associated to ovarian cancer

Cited by 18 publications

References 46 publications

The expression signature of cancer‐associated KRAB‐ZNF factors identified in TCGA pan‐cancer transcriptomic data

The expression signature of cancer‐associated KRAB‐ZNF factors identified in TCGA pan‐cancer transcriptomic data

Knockdown of ZNF280A inhibits the development and progression of ovarian cancer

Alternative RNA Splicing: New Approaches for Molecular Marker Discovery in Cancer

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