Splenopentin (DAc-SP5) - Influence on Engraftment and Graft-vs-Host Reaction after Non-H-2 Bone Marrow Transplantation in Mice

Abstract

The influence of DAc-SP5 on engraftment and graft-vs-host reaction (GVHR) was studied in different non-H-2 strain combinations. The engraftment was more or less enhanced in every case, whereas the situation in the GVHR was completely different. In one case splenopentin did not influence the course of the GVHR so much, in a second case the symptoms of the GVHR were completely abolished, and in a third case the GVHR was dramatically enhanced up to a great mortality. Therefore, before application of DAc-SP5 to the bone marrow transplantation in humans in order to improve the engraftment, parameters have to be found which allow an exact prediction about the influence of splenopentin on the GVHR in each single case.