Splenopentin (DAc SP-5) — Accelerated Reconstitution of Antibody Formation after Syngeneic Bone Marrow Transplantation <sup>*</sup>)

Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin deprived of these cells. A high dose of cyclophosphamide or dexamethasone led to a drastic decrease of LC density in murine skin with slow and incomplete restoration. SP-5 accelerated Langerhans cell recruitment and led to pretreatment levels of Langerhans cell density in the skin. These results indicate that SP-5 may possibly be used to treat disorders (e.g., HIV infection) where impaired Langerhans cell density and function can lead to secondary cutaneous infections.

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Stimulation of the recruitment of epidermal Langerhans cells by splenopentin

Grüner

Diezel

Strunk

et al. 1990

Arch Dermatol Res

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Thymopentin and splenopentin as immunomodulators

et al. 1998

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Splenopentin (SP-5, Arg-Lys-Glu-Val-Tyr) and thymopentin (TP-5, Arg-Lys-Asp-Val-Tyr) are synthetic immunomodulating peptides corresponding to the region 32-34 of a splenic product called splenin (SP) and the thymic hormone thymopoietin (TP), respectively. TP was originally isolated as a 5-kDa (49-amino acids) protein from bovine thymus while studying effects of the thymic extracts on neuromuscular transmission and was subsequently observed to affect T cell differentiation and function. TP I and II are two closely related polypeptides isolated from bovine thymus. A radioimmunoassay for TP revealed a crossreaction with a product found in spleen and lymph node. This product, named splenin, differs from TP only in position 34, aspartic acid for bovine TP and glutamic acid for bovine splenin and it was called TP III as well. Synthetic pentapeptides (TP-5) and (SP-5), reproduce the biological activities of TP and SP, respectively. It is now evident that various forms of TPs were created by proteolytic cleavage of larger proteins during isolation. cDNA clones have been isolated for three alternatively spliced mRNAs that encodes three distinct human T cell TPs. The immunomodulatory properties of TP, SP, TP-5, SP-5 and some of their synthetic analogs reported in the literature have been briefly reviewed.

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Splenopentin (DAc SP-5) — Accelerated Reconstitution of Antibody Formation after Syngeneic Bone Marrow Transplantation ^*)

Cited by 2 publications

References 6 publications

Stimulation of the recruitment of epidermal Langerhans cells by splenopentin

Stimulation of the recruitment of epidermal Langerhans cells by splenopentin

Thymopentin and splenopentin as immunomodulators

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Splenopentin (DAc SP-5) — Accelerated Reconstitution of Antibody Formation after Syngeneic Bone Marrow Transplantation *)

Cited by 2 publications

References 6 publications

Stimulation of the recruitment of epidermal Langerhans cells by splenopentin

Stimulation of the recruitment of epidermal Langerhans cells by splenopentin

Thymopentin and splenopentin as immunomodulators

Contact Info

Product

Resources

About

Splenopentin (DAc SP-5) — Accelerated Reconstitution of Antibody Formation after Syngeneic Bone Marrow Transplantation ^*)