Splenomegaly With Rare Morphologically Distinct Histiocyte

Silverstein, Murray N.; Young, Donald G.; ReMine, William H.; Pease, Gertrude L.

doi:10.1001/archinte.1964.03860080101010

Cited by 30 publications

(8 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The nomenclature used for these cells as well as the nature of the substance within them have been a mat ter of controversy over the years. Terminology such as 'sea-blue histiocytosis' [5,6,[21][22][23][24][25][26], Gaucher and Gaucher-like cells [4,[7][8][9]20] and splenic lipidosis [27] have been repeatedly used as synonyms for these cells.…”

Section: Introductionmentioning

confidence: 99%

Splenic Foam Cells: A Clinico-Pathologic Analysis of 92 Splenectomized Patients

Satti¹,

Melha²,

Al-Sohaibani³

et al. 1990

Acta Haematol

View full text Add to dashboard Cite

Spleens from 92 patients who underwent splenectomy for various indications were examined. These indications included hematologic disease in 38 patients and nonhematologic problems in 54. Of all the group foam cells were seen in hematoxylin and eosin (HE)-stained sections of spleens from 12 patients. This number increased to 21 (23%) when the diastase periodic acid-Schiff stain was used as a screening test. The cells in these 9 additional cases were too scanty to be observed on HE-stained sections alone. All the 21 spleens with positive foam cells were from patients with hematologic disease, specifically β-thalassemia major, hemoglobin S/β-thalassemia, hemoglobin AS, and idiopathic thrombocytopenic purpura. None of the spleens from the 54 nonhematologic patients showed foam cells. Factors that determine the probability of presence of foam cells were calculated. Also, certain differences in the staining reactions of foam cells were observed. The results of both, and the relation of these foam cells to the ‘syndrome of the sea-blue histiocyte’ are presented and discussed.

show abstract

Section: Introductionmentioning

confidence: 99%

Splenic Foam Cells: A Clinico-Pathologic Analysis of 92 Splenectomized Patients

Satti¹,

Melha²,

Al-Sohaibani³

et al. 1990

Acta Haematol

View full text Add to dashboard Cite

show abstract

“…Patchy or irregular brown pigmentation of the skin was noticed in 4 p a t i e n t~~~~~, 62 with the syndrome, whereas albinism was conversely documented in a few patients.58 On X-ray examination, pulmonary infiltrates were found in 7 c a s e~.~~~~O Referring to these clinical signs and symptoms of the syndrome to the present case, the diagnosis of syndrome of sea-blue histiocyte can be made, because the case showed hepatosplenomegaly, bleeding tendency, mild thrombocytopenia, fatty liver with cirrhosis, and brownish skin pigmentation, though no neurological disturbances, ophthalmologic abnormalities, superficial lymphadenopathy, or pulmonary idltrates on X-ray films were observed.…”

Section: Discussionmentioning

confidence: 99%

SYNDROME OF THE SEA‐BLUE HISTIOCYTE —The First Case Report in Japan and Review of the Literature—

Tachibana¹,

Hakozaki

Takahashi

et al. 1979

Acta Pathologica Japonica

View full text Add to dashboard Cite

A case of the syndrome of sea‐blue histiocyte is presented in a 53‐year‐old Japanese woman, which is the first recorded case in Japan. The patient had hepatosplenomegaly, bleeding manifestations, mild thrombocytopenia, fatty metamorphosis and cirrhosis of the liver, as well as abnormal serum lipid profiles. Her parents were consanguineous and her maternal grandmother with hepatomegaly died of hepatic failure. Histologically, peculiar histiocytes containing numerous, intracytoplasmic sea‐blue stained granules on May‐Giemsa stain were demonstrated in biopsy materials of the bone marrow, lymph node and liver. The sea‐blue granules in these histiocytes proved to have histochemical staining characteristics of lipogenic ceroid‐like pigment. Ultrastructurally, these granules showed membrane‐bound, pleomorphic inclusions of heterogeneous nature, including electron‐dense amorphous or variegatedly osmiophilic, frequently laminated materials. Enzyme cyto‐chemically, localization of acid phosphatase activity was demonstrated in and around the intracytoplasmic inclusions. With regard to the pathogenesis of the sea‐blue histiocytes in this case, it may be suggested that the existence of the abnormality in lipid metabolism plays an imporant role in intralysosomal ceroidogenesis in these histiocytes.

show abstract

“…Using various histochemical techniques several authors have demonstrated that the 'sea-blue' granules stain for phospholipid and glycolipid, but do not stain with haematoxylin/eosin or toluidine blue (Silverstein et al 1964, 1970, Jones et al 1970). Sawitsky et al (1954) concluded that the granules contained mucopolysaccharides, based on the PAS stain.…”

Section: Discussionmentioning

confidence: 99%

“…Sawitsky et al (1954) concluded that the granules contained mucopolysaccharides, based on the PAS stain. Chemical analysis of extracts from the enlarged liver or spleen (Marshall & Adams 1958, Silverstein et al 1964, 1970 disclosed an increased content of glycolipids, sphingomyelin and other phospholipids. Increased urinary excretion of mucopolysaccharides was found by Sawitsky et al (1954) and by Silverstein et al (1970).…”

Section: Discussionmentioning

confidence: 99%

Sea‐Blue Histiocytes in Familial Lecithin: Cholesterol Acyltransferase Deficiency

Jacobsen

Gjone

Hovig

1972

Scandinavian Journal of Haematology

View full text Add to dashboard Cite

Histiocytes containing large blue‐green granules on Wright or Giemsa stain have been described in several different clinical conditions, some of them with hepatosplenomegaly and thrombocytopenia. These conditions have been ill‐defined with no common characteristics. In the present report evidence is given for the presence of ‘sea‐blue histiocytes’ in all five patients with familial lecithin: cholesterol acyltransferase deficiency examined. From electron microscopic studies it is suggested that the characteristic cytological appearance of the histiocytes in the spleen and bone marrow in these patients may be due to increased phagocytosis and decomposition of blood cells, or more probably to uptake of phospholipid‐containing membraneous material directly from plasma.

show abstract

Splenomegaly With Rare Morphologically Distinct Histiocyte

Cited by 30 publications

References 4 publications

Splenic Foam Cells: A Clinico-Pathologic Analysis of 92 Splenectomized Patients

Splenic Foam Cells: A Clinico-Pathologic Analysis of 92 Splenectomized Patients

SYNDROME OF THE SEA‐BLUE HISTIOCYTE —The First Case Report in Japan and Review of the Literature—

Sea‐Blue Histiocytes in Familial Lecithin: Cholesterol Acyltransferase Deficiency

Contact Info

Product

Resources

About